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Systematic molecular evolution enables robust biomolecule discovery
Nature Methods, 2021Evolution occurs when selective pressures from the environment shape inherited variation over time. Within the laboratory, evolution is commonly used to engineer proteins and RNA, but experimental constraints have limited the ability to reproducibly and reliably explore factors such as population diversity, the timing of environmental changes and ...
Erika A. DeBenedictis +5 more
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Ontology Robustness in Evolution
2008This paper introduces the notion of Ontology Robustness in Evolution and discusses a solution based on the distinction among a stable component and a contingent component of the ontology. The stable component represents the annotation used to store data into the ontology, while the contingent component contains assertions generated by constraining the ...
P. Ceravolo, E. Damiani, M. Leida
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Robust, Producible Design Process Evolution
Quality Engineering, 2007 As recently as a decade ago, design engineering and manufacturing at GE Aviation were separate organizations. Nonconformance control by a material review board was used by design engineering to monitor manufacturing quality. While this process produc..
David Rumpf +3 more
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Evolution Strategies for Robust Optimization
2006 IEEE International Conference on Evolutionary Computation, 2006In this paper, we propose two evolutionary strategies for the optimization of problems with actuator noise as encountered in robust optimization, where the design or objective parameters are subject to noise: the ROSAES and the ROCSAES. Both algorithms use a control rule for increasing the population size when the residual error to the optimizer state ...
H.-G. Beyer, B. Sendhoff
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Robust Evolution in Historical Time
International Philosophical Quarterly, 2020The normalized, deterministic conception of evolution espoused by Dennett is increasingly being challenged by theorists who, following Gould, emphasize the role that historical contingencies play in it. I explore the conflict between these views and argue that correcting our understanding of the relationship between nature’s systematic necessities and ...
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Evolution of Phenotypic Robustness
2005Abstract Evolutionary biology, in the neo-Darwinian tradition, is based on the study of genetic and phenotypic variation and its fate in populations. Thus, the observation that the genetic variability of a trait is itself influenced by the genotype has obvious theoretical implications [49, 55].
Joachim Hermisson, Gunter P Wagner
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Robustness and network evolution—an entropic principle
Physica A: Statistical Mechanics and its Applications, 2005Abstract This article introduces the concept of network entropy as a characteristic measure of network topology. We provide computational and analytical support for the hypothesis that network entropy is a quantitative measure of robustness. We formulate an evolutionary model based on entropy as a selective criterion and show that (a) it predicts the
Demetrius, L., Manke, T.
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Evolution of robust and efficient system topologies
Cellular Immunology, 2006Mutation/selection algorithms were applied to increase the efficiency and the robustness of sparse random networks. Selection for better efficiency leads to the well-known star topology, while selection for robustness only results in a relatively dense core and a small periphery.
Sergiu, Netotea, Sándor, Pongor
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Plasticity, Robustness, Development and Evolution
2011How do we understand and explain the apparent dichotomy between plasticity and robustness in the context of development? Can we identify these complex processes without resorting to 'either/or' solutions? Written by two leaders in the field, this is the first book to fully unravel the complexity of the subject, explaining that the epigenetic processes ...
Patrick Bateson, Peter Gluckman
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Redox robustness drives LPMO evolution
AbstractEnzymes known as lytic polysaccharide monooxygenases (LPMOs) are exceptionally powerful small redox enzymes that master the controlled generation and productive use of potentially damaging hydroxyl radicals in what is essentially a H2O2-driven peroxygenase reaction.Iván Ayuso-Fernández +8 more
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