Results 41 to 50 of about 3,019,839 (180)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Environmental noise, genetic diversity and the evolution of evolvability and robustness in model gene networks. [PDF]

PLoS ONE, 2012
The ability of organisms to adapt and persist in the face of environmental change is accepted as a fundamental feature of natural systems. More contentious is whether the capacity of organisms to adapt (or "evolvability") can itself evolve and the ...
Christopher F Steiner
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Mechanisms of Mutational Robustness in Transcriptional Regulation

Frontiers in Genetics, 2015
Robustness is the invariance of a phenotype in the face of environmental or genetic change. The phenotypes produced by transcriptional regulatory circuits are gene expression patterns that are to some extent robust to mutations.
Joshua L. Payne, Joshua L. Payne, Andreas eWagner, Andreas eWagner, Andreas eWagner   +4 more
doaj   +1 more source

Robustness from flexibility in the fungal circadian clock [PDF]

, 2010
Background Robustness is a central property of living systems, enabling function to be maintained against environmental perturbations. A key challenge is to identify the structures in biological circuits that confer system-level properties such as ...
Andrew J Millar, Paul E Brown, David A Rand, Akman, Ozgur E., Rand, D. A. (David A.), Akman, Ozgur E, Brown, Paul E, Rand, David A., Ozgur E Akman, Millar, Andrew J; id_orcid, Brown, Paul E., Millar, A. J. (Andrew J.), Millar, Andrew J., Rand, David A   +13 more
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

In silico genetic robustness analysis of microRNA secondary structures: potential evidence of congruent evolution in microRNA

BMC Evolutionary Biology, 2007
Background Robustness is a fundamental property of biological systems and is defined as the ability to maintain stable functioning in the face of various perturbations.
Ni Ming, Bo Xiaochen, Shu Wenjie, Zheng Zhiqiang, Wang Shengqi   +4 more
doaj   +1 more source

Robustness of the long-term nonlinear evolution of global sea surface temperature trend

Geoscience Letters, 2022
The multi-scale variability of global sea surface temperature (GSST), which is often dominated by secular trends, significantly impacts global and regional climate change. Previous studies were mainly carried out under linear assumptions.
Zhenhao Xu, Gang Huang, Fei Ji, Bo Liu, Fei Chang, Xichen Li   +5 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source