Results 41 to 50 of about 578,574 (323)

Recombination and the evolution of mutational robustness

Journal of Theoretical Biology, 2006
Mutational robustness is the degree to which a phenotype, such as fitness, is resistant to mutational perturbations. Since most of these perturbations will tend to reduce fitness, robustness provides an immediate benefit for the mutated individual. However, robust systems decay due to the accumulation of deleterious mutations that would otherwise have ...
Gardner, A, Kalinka, A
openaire   +3 more sources

Highly Optimized Tolerance: Robustness and Design in Complex Systems [PDF]

, 2000
Highly optimized tolerance (HOT) is a mechanism that relates evolving structure to power laws in interconnected systems. HOT systems arise where design and evolution create complex systems sharing common features, including (1) high efficiency ...
Carlson, J. M., Doyle, John
core   +1 more source

Direct evolution of genetic robustness in microRNA [PDF]

Proceedings of the National Academy of Sciences, 2006
Genetic robustness, the invariance of the phenotype in the face of genetic perturbations, can endow the organism with reduced susceptibility to mutations. A large body of work in recent years has focused on the origins, mechanisms, and consequences of robustness in a wide range of biological systems.
Elhanan, Borenstein, Eytan, Ruppin
openaire   +2 more sources

The robustness of a signaling complex to domain rearrangements facilitates network evolution. [PDF]

PLoS Biology, 2014
The rearrangement of protein domains is known to have key roles in the evolution of signaling networks and, consequently, is a major tool used to synthetically rewire networks.
Paloma M Sato, Kogulan Yoganathan, Jae H Jung, Sergio G Peisajovich   +3 more
doaj   +1 more source

Scale-free networks are not robust under neutral evolution

, 2001
Recently it has been shown that a large variety of different networks have power-law (scale-free) distributions of connectivities. We investigate the robustness of such a distribution in discrete threshold networks under neutral evolution.
Bollobás B., Bornholdt S., Darwin C., Derrida B., Kauffman S. A., Kimura M., Kürten K. E., M Hörnquist   +7 more
core   +1 more source

On Robust Evolution of Digital Hardware [PDF]

, 2008
In this paper we investigate whether multi-objective evolution of digital hardware components has advantages over single-objective evolution in terms of convergence and robustness. To that end, we experimentally compare a standard genetic algorithm to several multi-objective optimizers on a set of test problems.
Tobias Knieper, Bertrand Defo, Paul Kaufmann, Marco Platzner   +3 more
openaire   +1 more source

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

Non-Darwinian Molecular Biology

Frontiers in Genetics, 2022
With the discovery of the double helical structure of DNA, a shift occurred in how biologists investigated questions surrounding cellular processes, such as protein synthesis. Instead of viewing biological activity through the lens of chemical reactions,
Alexander F. Palazzo, Nevraj S. Kejiou
doaj   +1 more source

Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul, Jatuporn Sujjitjoon, Pa‐thai Yenchitsomanus, Kridtin Jarutatsanangkoon, Ng Wei Loon, Kleebsabai Sanpakit, Jassada Buaboonnam, Chayamon Takpradit, Pornpimon Yuti, Nunghathai Sawasdee, Piriya Luangwattananun, Siripakorn Sangkitporn, Arnan Limmahachai, La‐ongsri Atchaneeyasakul   +13 more
wiley   +1 more source

A robust audio steganography algorithm based on differential evolution

Dianxin kexue, 2021
Audio steganography is to hide secret information into the audio carrier and has become a research hotspot in the field of information hiding.Most of the existing studies focus on minimizing distortion at the expense of steganography capacity, and it is ...
Zhaopin SU, Chaoyong SHEN, Guofu ZHANG, Feng YUE, Donghui HU   +4 more
doaj   +2 more sources