Results 21 to 30 of about 578,574 (323)
Genes confer similar robustness to environmental, stochastic, and genetic perturbations in yeast. [PDF]
PLoS ONE, 2010 Gene inactivation often has little or no apparent consequence for the phenotype of an organism. This property-enetic (or mutational) robustness-is pervasive, and has important implications for disease and evolution, but is not well understood.
Ben Lehner
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Evolution of Robustness to Protein Mistranslation by Accelerated Protein Turnover. [PDF]
PLoS Biology, 2015 Translational errors occur at high rates, and they influence organism viability and the onset of genetic diseases. To investigate how organisms mitigate the deleterious effects of protein synthesis errors during evolution, a mutant yeast strain was ...
Dorottya Kalapis +10 more
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Effects of ploidy and recombination on evolution of robustness in a model of the segment polarity network. [PDF]
PLoS Computational Biology, 2009 Many genetic networks are astonishingly robust to quantitative variation, allowing these networks to continue functioning in the face of mutation and environmental perturbation. However, the evolution of such robustness remains poorly understood for real
Kerry J Kim, Vilaiwan M Fernandes
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Robustness of adiabatic quantum computation [PDF]
, 2001 We study the fault tolerance of quantum computation by adiabatic evolution, a quantum algorithm for solving various combinatorial search problems. We describe an inherent robustness of adiabatic computation against two kinds of errors, unitary control ...
Andrew M. Childs +13 more
core +2 more sources
Molecular Systems Biology, 2008 Gene expression, like many biological processes, is subject to noise. This noise has been measured on a global scale, but its general importance to the fitness of an organism is unclear.
Ben Lehner
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EvoRSR: an integrated system for exploring evolution of RNA structural robustness
BMC Bioinformatics, 2009 Background Robustness, maintaining a constant phenotype despite perturbations, is a fundamental property of biological systems that is incorporated at various levels of biological complexity.
Ni Ming +4 more
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Assessing the robustness of parsimonious predictions for gene neighborhoods from reconciled phylogenies [PDF]
, 2015 The availability of a large number of assembled genomes opens the way to study the evolution of syntenic character within a phylogenetic context. The DeCo algorithm, recently introduced by B{\'e}rard et al.
Chauve, Cedric +2 more
core +5 more sources
Developmental Evolution: Getting Robust About Robustness [PDF]
Current Biology, 2002 In the context of development, a process is robust if it can proceed normally despite the enormous capacity for perturbation inherent in all biological systems. A new mode of theoretical modeling of genetic networks holds great promise for increasing our understanding of both the quantitative mechanisms of robustness and its evolutionary impact.
openaire +4 more sources
ImOSM: Intermittent Evolution and Robustness of Phylogenetic Methods [PDF]
Molecular Biology and Evolution, 2011 Among the criteria to evaluate the performance of a phylogenetic method, robustness to model violation is of particular practical importance as complete a priori knowledge of evolutionary processes is typically unavailable. For studies of robustness in phylogenetic inference, a utility to add well-defined model violations to the simulated data would be
Minh Anh Nguyen +2 more
openalex +4 more sources
Evolution favors protein mutational robustness in sufficiently large populations
BMC Biology, 2007 Background An important question is whether evolution favors properties such as mutational robustness or evolvability that do not directly benefit any individual, but can influence the course of future evolution.
Venturelli Ophelia S +5 more
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