Results 11 to 20 of about 578,574 (323)
Maladaptation and the paradox of robustness in evolution. [PDF]
PLoS ONE, 2007 Organisms use a variety of mechanisms to protect themselves against perturbations. For example, repair mechanisms fix damage, feedback loops keep homeostatic systems at their setpoints, and biochemical filters distinguish signal from noise.
Steven A Frank
doaj +6 more sources
Evolution of robustness in digital organisms [PDF]
Artificial Life, 2004 We study the evolution of robustness in digital organisms adapting to a high mutation rate. As genomes adjust to the harsh mutational environment, the mean effect of single Imitations decreases, up until the point where a sizable fraction (up to 30% in ...
Adami, Christoph, Edlund, Jeffrey A.
core +5 more sources
Evolution of drift robustness in small populations [PDF]
Nature Communications, 2017 Genetic drift can reduce fitness in small populations by counteracting selection against deleterious mutations. Here, LaBar and Adami demonstrate through a mathematical model and simulations that small populations tend to evolve to drift-robust fitness ...
Thomas LaBar, Christoph Adami
doaj +3 more sources
The Effect of Recombination on the Neutral Evolution of Genetic Robustness [PDF]
Mathematical Biosciences, 2008 Conventional population genetics considers the evolution of a limited number of genotypes corresponding to phenotypes with different fitness. As model phenotypes, in particular RNA secondary structure, have become computationally tractable, however, it ...
Albert +17 more
core +3 more sources
Robust Contract Evolution in a TypeSafe MicroServices Architecture [PDF]
The Art, Science, and Engineering of Programming, 2020 Microservices architectures allow for short deployment cycles and immediate effects but offer no safety mechanisms when service contracts need to be changed. Maintaining the soundness of microservice architectures is an error-prone task that is only accessible to the most disciplined development teams.
João Costa Seco +4 more
openalex +5 more sources
Neutral evolution of mutational robustness [PDF]
Proceedings of the National Academy of Sciences, 1999 We introduce and analyze a general model of a population evolving over a network of selectively neutral genotypes. We show that the population’s limit distribution on the neutral network is solely determined by the network topology and given by the principal eigenvector of the network’s adjacency matrix.
van Nimwegen, Erik +2 more
openaire +6 more sources
Revisiting robustness and evolvability: evolution in weighted genotype spaces. [PDF]
PLoS ONE, 2014 Robustness and evolvability are highly intertwined properties of biological systems. The relationship between these properties determines how biological systems are able to withstand mutations and show variation in response to them. Computational studies
Raghavendran Partha, Karthik Raman
doaj +1 more source
A Role for Selection in the Evolution of Genetic Robustness.
PLoS Biology, 2005 doaj +3 more sources
Evolution of robustness and cellular stochasticity of gene expression. [PDF]
PLoS Biology, 2013 Gene expression varies widely in cells with the same genotype and environment. Predicting the patterns of stochastic cellular fluctuations remains an unsolved challenge.
Steven A Frank
doaj +1 more source
Does mutational robustness inhibit extinction by lethal mutagenesis in viral populations? [PDF]
PLoS Computational Biology, 2010 Lethal mutagenesis is a promising new antiviral therapy that kills a virus by raising its mutation rate. One potential shortcoming of lethal mutagenesis is that viruses may resist the treatment by evolving genomes with increased robustness to mutations ...
Eamon B O'Dea +2 more
doaj +1 more source