EvoEvo Deliverable 3.2: Evolution of robustness: mechanisms and consequences [PDF]
, 2016 Evolution of robustness; Mechanisms and consequences: A report describing how robustness is indirectly selected in the model and its consequences on ...
Beslon, Guillaume, Hogeweg, Paulien
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Parasites lead to evolution of robustness against gene loss in host signaling networks [PDF]
Molecular Systems Biology, 2008 Many biological networks can maintain their function against single gene loss. However, the evolutionary mechanisms responsible for such robustness remain unclear.
Marcel Salathé, Orkun S Soyer
doaj +2 more sources
Cluster damage robustness analysis and space independent community detection in complex networks [PDF]
, 2012 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.This thesis investigates the evolution of two very different complex systems using network theory. This multi-disciplinary technique is widely used to model
Gegov, Emil
core +7 more sources
Robustness analysis of magnetic torquer controlled spacecraft attitude dynamics [PDF]
, 2009 This paper describes a systematic approach to the robustness analysis of linear periodically time-varying (LPTV) systems. The method uses the technique known as Lifting to transform the original time-varying uncertain system into linear fractional ...
Postlethwaite, I., Kim, J., Bates, D.G.
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Does mutational robustness inhibit extinction by lethal mutagenesis in viral populations? [PDF]
PLoS Computational Biology, 2010 Lethal mutagenesis is a promising new antiviral therapy that kills a virus by raising its mutation rate. One potential shortcoming of lethal mutagenesis is that viruses may resist the treatment by evolving genomes with increased robustness to mutations ...
Eamon B O'Dea +2 more
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Evolution of Robustness to Protein Mistranslation by Accelerated Protein Turnover. [PDF]
PLoS Biology, 2015 Translational errors occur at high rates, and they influence organism viability and the onset of genetic diseases. To investigate how organisms mitigate the deleterious effects of protein synthesis errors during evolution, a mutant yeast strain was ...
Dorottya Kalapis +10 more
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The evolution and mutational robustness of chromatin accessibility in Drosophila
Genome Biology, 2023 Background The evolution of genomic regulatory regions plays a critical role in shaping the diversity of life. While this process is primarily sequence-dependent, the enormous complexity of biological systems complicates the understanding of the factors ...
Samuel Khodursky +7 more
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Genes confer similar robustness to environmental, stochastic, and genetic perturbations in yeast. [PDF]
PLoS ONE, 2010 Gene inactivation often has little or no apparent consequence for the phenotype of an organism. This property-enetic (or mutational) robustness-is pervasive, and has important implications for disease and evolution, but is not well understood.
Ben Lehner
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Evolution of drift robustness in small populations
Nature Communications, 2017 Genetic drift can reduce fitness in small populations by counteracting selection against deleterious mutations. Here, LaBar and Adami demonstrate through a mathematical model and simulations that small populations tend to evolve to drift-robust fitness ...
Thomas LaBar, Christoph Adami
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Molecular Systems Biology, 2008 Gene expression, like many biological processes, is subject to noise. This noise has been measured on a global scale, but its general importance to the fitness of an organism is unclear.
Ben Lehner
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