Results 111 to 120 of about 2,344,066 (336)

Fibulin2 is a good diagnostic and prognostic indicator for sepsis

BMC Infectious Diseases
Background Sepsis is a life-threatening syndrome characterized by multiple organ dysfunction resulting from a maladjusted host response to infection. It remains a leading cause of morbidity and mortality worldwide.
Xiaowen Gao, Shidan Li, Jinze Wu, Yiyun Feng, Wei Xing, Xiaoming Li, Yimin Du, Debin Guo, Honghao Xu, Dongqin Tang, Shaochuan Wang, Youbin Li, Jing Yang, Jianfei Ma, Yamei Zhang, Lei Li, Jun Fei   +16 more
doaj   +1 more source

Understanding and Circumventing Failure Mechanisms in Chalcogenide Optical Phase Change Material Ge2Sb2Se4Te

Advanced Optical Materials, Volume 13, Issue 8, March 13, 2025.
Chalcogenide optical PCMs have gathered interest for their potential in compact, non‐volatile optics and photonics. Free‐space PCM metasurfaces require new considerations from phase change memory that need to be addressed for reliable scale‐up. Several failure mechanisms pertaining to free‐space PCM devices and layout methods are isolated to prevent ...
Cosmin Constantin Popescu, Kiumars Aryana, Brian Mills, Tae Woo Lee, Louis Martin‐Monier, Luigi Ranno, Jia Xu Brian Sia, Khoi Phuong Dao, Hyung‐Bin Bae, Vladimir Liberman, Steven A. Vitale, Myungkoo Kang, Kathleen A. Richardson, Carlos A. Ríos Ocampo, Dennis Calahan, Yifei Zhang, William M. Humphreys, Hyun Jung Kim, Tian Gu, Juejun Hu   +19 more
wiley   +1 more source

Multi‐Material Additive Manufacturing of Soft Robotic Systems: A Comprehensive Review

Advanced Robotics Research, EarlyView.
This review explores the transformative role of multi‐material additive manufacturing (MMAM) in the development of soft robotic systems. It presents current techniques, materials, and design strategies that enable functionally graded and adaptive structures.
Ritik Raj, Quan‐Chen Song, Jia‐Yang Juang   +2 more
wiley   +1 more source

First‐Principles Structure–Activity Relationship Insights Into Phenolic Scaffolds: QSAR Modeling and Drug‐Likeness Screening

Advanced Theory and Simulations, EarlyView.
Integrated machine learning framework for phenolic derivatives: classification (toxicity) and regression (logP) models identify top drug‐like compounds. Random Forest outperformed for toxicity, while Linear Regression best predicted logP. A weighted scoring approach prioritized five safe, lipophilicity‐optimized candidates, supporting rational ...
Houria Nacer, Sridhar Priyankha, Gopal Hema, Anouar Zerouali, Hamza Haddag, Muneerah Mogren Al Mogren, Muthuramalingam Prakash, Majdi Hochlaf   +7 more
wiley   +1 more source

Multiomics Analyses Reveal an Essential Role of Tryptophan in Treatment of csDMARDs in Rheumatoid Arthritis

Advanced Science, EarlyView.
Rheumatoid arthritis is a disease characterized by joint inflammation. Approximately 50% of patients show insufficient response to traditional synthetic disease‐modifying antirheumatic drugs. This study aims to elucidate differential molecular profiles of the mechanisms underlying drug responses through multi‐omics strategy.
Congcong Jian, Jing Zhu, Jianhong Wu, Yan Zhang, Jianghua Chen, Huan Wang, Hengyan Liu, Ke Xu, Jiaxin Huang, Xiaoting Zhu, Yuanli Wei, Shilin Li, Tingting Wang, Xuan Huang, Qinghua Zou, Jie Zhang, Jiang Su, Xinming Du, Yaping Lu, Tianci Zhou, Yingtong Zhou, Minglong Tang, Bin Li, Xue Zhou, Qihao Wei, Qiulong Yan, Fanxin Zeng   +26 more
wiley   +1 more source

A Multiclass ROC Curve

This paper introduces a novel methodology for constructing multiclass ROC curves using the multidimensional Gini index. The proposed methodology leverages the established relationship between the Gini coefficient and the ROC Curve and extends it to multiclass settings through the multidimensional Gini index.
Giudici, Paolo, Rosciano, Rosa C., Schrader, Johanna, Kummerfeld, Delf-Magnus   +3 more
openaire   +2 more sources

A Simple Generalisation of the Area Under the ROC Curve for Multiple Class Classification Problems

Machine-mediated learning, 2001
D. Hand, R. Till
semanticscholar   +1 more source

VDLIN: A Deep Learning‐Based Platform for Methylcobalamin‐Inspired Immunomodulatory Compound Screening

Advanced Science, EarlyView.
Using the convolutional neural network model VDLIN, Co7 is identified as a promising therapeutic candidate. Co7 demonstrates distinct advantages over MCB by effectively balancing anti‐inflammatory and immune‐stimulatory functions, making it a potential novel approach for immune modulation.
Xuefei Guo, Yang Zhao, Xianle Rong, Chenxi Niu, Shiyu Hu, Qiang Liu, Fuping You   +6 more
wiley   +1 more source

NARFL Knockout Triggers Ferroptosis‐Driven Vascular Endothelial Dysfunction

Advanced Science, EarlyView.
NARFL is vital for CIA and oxidative stress resistance. NARFL deletion in HPMEC cells, zebrafish, and mice is lethal and rescued by a Ferroptosis inhibitor. NARFL deficiency disrupted its interaction with CIA proteins, decreased aconitase activity, increased IRP1 activity, induced Fe overload, and led to ferroptosis and oxidative stress, resulting in ...
Hui Hu, Jing Luo, Li Yu, Daoxi Qi, Boyu Li, Yating Chen, Chen Wang, Xiaokang Zhang, Wenzheng Guo, Qiyong Lou, Gang Zhai, Yonglin Ruan, Jianfei Huang, Shengchi Shi, Zhan Yin, Fang Zheng   +15 more
wiley   +1 more source

Receiver operating characteristic (ROC) curves of transoesophageal echocardiography (TEE) Doppler parameters to predict an invasive pulmonary artery occlusion pressure (PAOP) ≤ 18 mmHg in protocol A

, 2011
Philippe Vignon, AitHssain Ali, F.P. Bruno, Preux Pierre-Marie, Nicolas Pichon, M. Clavel, Florence Niedergang, H. Gastinne   +7 more
openalex   +1 more source