Results 81 to 90 of about 302,402 (283)
Advanced Science, EarlyView.Treatment of MPTP‐incubated cells with NAD+‐boosters increase the UPRmt/mitophagy‐related mitochondria quality control (MQC). Disturbed plasma UPRmt‐mitophagy‐mediated MQC profiles in PD patient samples. NMN inhibits motor deficit and forestalls neuropathology phenotypes of PD mice, which is required the atf4‐medicated UPRmt pathway.
Shuoting Zhou +16 more
wiley +1 more source
Advanced Science, EarlyView.Glucose deprivation or GLUT1 inhibition induces disulfidptosis in SLC7A11high ovarian cancer cells by promoting cystine accumulation, NADPH/ATP depletion, and F‐actin disulfide formation. SLC7A11 interacts with INF2 to further increase H₂O₂ levels and impair mitochondrial fission, suppressing cell migration. Targeting the SLC7A11–INF2 axis represents a
Zhenyu Song +9 more
wiley +1 more source
plotROC: A Tool for Plotting ROC Curves [PDF]
Journal of Statistical Software, 2017 Plots of the receiver operating characteristic (ROC) curve are ubiquitous in medical research. Designed to simultaneously display the operating characteristics at every possible value of a continuous diagnostic test, ROC curves are used in oncology to evaluate screening, diagnostic, prognostic and predictive biomarkers. I reviewed a sample of ROC curve
openaire +5 more sources
Advanced Science, EarlyView.Overview of the Genetic Deafness Commons (GDC), integrating data from the Chinese Deafness Genetics Consortium (CDGC) and 51 public databases. The GDC provides tools for variant search, functional predictions, and gene‐disease visualization, offering insights into 201 hearing loss genes and facilitating novel gene discovery and clinical applications ...
Hui Cheng +11 more
wiley +1 more source
Advanced Science, EarlyView.Midkine (MDK) is a mediator of the interaction between pancreatic cancer and beta cells. MDK, which originated from pancreatic ductal adenocarcinoma cells, exerted deleterious effects on paraneoplastic beta cells by binding to the SDC4 receptor on the beta cell surface and subsequently downregulating the Ras signaling pathway, thereby impairing insulin
Zengyu Feng +7 more
wiley +1 more source
ROC Curves for Multiple-Signal Levels in a Detection Task [PDF]
, 1967 Ann Tucker +2 more
openalex +1 more source
On the shape of energy-detection ROC curves [PDF]
Perception & Psychophysics, 1990 A numerical study shows that energy-detection ROC curves based on chi-squared distributions may be accurately represented by binormal receiver operating characteristic (ROC) curves. This allows the detector accuracy and the ROC shape (asymmetry) to be expressed simply in terms of the distribution parameters.
openaire +3 more sources
Advanced Science, EarlyView.METTL14/IGF2BP2‐mediated m6A modification drives LINC01094 upregulation in BC. Then, LINC01094 interacts with PKM2 monomers to promote their dimerization, while serving as a flexible scaffold to facilitate the assembly of the PKM2/JMJD5 complex, synergistically stabilizing PKM2 dimers and enhancing their nuclear translocation.
Mengqi Wang +8 more
wiley +1 more source
Number of steps per day and the screening of cardiovascular disease risk factors in adolescents
Motriz: Revista de Educacao Fisica, 2016 Pedometers have been used in some studies to measure physical activity in adolescents. However, cutoff points of steps per day that classify physical activity levels are not yet fully established.
Júlio Brugnara Mello +3 more
doaj +1 more source
Factors affecting the slope of empirical ROC curves: Comparison of binary and rating responses [PDF]
, 1967 Joseph Markowitz, John A. Swets
openalex +1 more source