Results 91 to 100 of about 141,212 (290)
Advanced Science, EarlyView.ABSTRACT Periodontitis, a chronic inflammatory disease initiated and sustained by plaque microorganisms and host immune response, remains an intractable oral disease and a leading cause of tooth loss worldwide. Traditional mechanical debridement and adjunctive antibiotic or antiseptic therapy often shows limited efficacy due to the complex anatomical ...
Weiyu Zhang +12 more
wiley +1 more source
The effects of a competitor on the foraging behaviour of the shore crab Carcinus maenas. [PDF]
, 2014 Optimal Diet Theory suggests that individuals make foraging decisions that maximise net energy intake. Many studies provide qualitative support for this, but factors such as digestive constraints, learning, predation-risk and competition can influence ...
Chakravarti, LJ, Cotton, PA
core +3 more sources
Proton FLASH Exposure Preserves Gut Commensal Microbiomes and Spares Intestinal Stem Cells
Advanced Science, EarlyView.This study highlights the role of Proton FLASH abdominal irradiation in sparing of intestinal stem cells and preservation of key gut microbial population resulting minimization of radiation toxicity in intestinal epithelium in mice. Our findings support the potential of Proton FLASH to improve the therapeutic ratio for abdominal radiation exposure ...
Rishi Man Chugh +11 more
wiley +1 more source
Impregnated drill bits strengthened by nanoparticles for mineral exploration drilling [PDF]
, 2018 In order to improve the drilling efficiency and service life of impregnated diamond drill bit, WC and ZrO2 nanoparticles were introduced into traditional drill bit matrix.
Baochang, L. +3 more
core
Application of fine-grained binding materials in technology of hardening backfill construction [PDF]
, 2014 The expediency of differential formation of high filling massif chambers based on a developed technology with usage of fine-grained binding materials.
Kuzmenko, O, Petlyovanyy, M
core +1 more source
Advanced Science, EarlyView.ABSTRACT Base editors enable precise genome modification and have emerged as a promising therapeutic approach for correcting diseases caused by single‐nucleotide variants. While the current efficient version of adenine base editors (ABEs), such as ABE8e, exhibits exceptional efficiency for A‐to‐G conversions, their clinical translation is hindered by ...
Jiawei Yao +12 more
wiley +1 more source
Advanced Science, EarlyView.Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang +11 more
wiley +1 more source
An Experimental and Numerical Simulation Study on Rock Cutting Based on Pre-Breaking
Shiyou jixie, 2019 The design of the mixed-cutter placement can only rely on the engineering experience. The combination of experiment and numerical simulation is used to study the rock breaking force and rock breaking efficiency of the PDC cutter under different pre ...
Liu Zhong, Hou Huihui, Hu Wei
doaj
Meitian dizhi yu kantanObjectiveTo improve the rock-breaking efficiency and durability of drill bits in the theoretical research on the optimal design of drill bits, the key is to systematically reveal both the rock-breaking mechanisms of polycrystalline diamond compact (PDC ...
Jiusen WEI, Xin HAN, Wei LIU, Deli GAO
doaj +1 more source
Advanced Science, EarlyView.This study investigates how CTCs survive varying shear stress during hematogenous metastasis. We uncover a self‐protection mechanism, by which non‐adherent CTCs adapt to high shearing milieu through accumulated cytoplasmic myosin‐mediated disruption of myosin‐actin binding, attenuating force transmission into chromatin to protect CTCs from shear ...
Cunyu Zhang +10 more
wiley +1 more source