Results 151 to 160 of about 1,873,571 (345)

Direct Extracellular Matrix Modulation Attenuates Intestinal Fibrosis via a Fibronectin‐Targeted Approach

Advanced Science, EarlyView.
Fibronectin regulates the extracellular matrix (ECM)–myofibroblast cycle through three key steps: (1) its secretion and assembly by myofibroblasts (inhibited by pUR4); (2) collagen deposition along its scaffold (inhibited by R1R2); and (3) integrin α5β1‐mediated mechanotransduction (inhibited by ATN161).
Wenlong Ma, Siyu Yang, Tengkai Wang, Di Zhang, Hewei Wu, Shichen Fu, Xiaohan Wan, Lixiang Li, Xiuli Zuo, Yanqing Li, Jiaoyang Lu   +10 more
wiley   +1 more source

Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma

Advanced Science, EarlyView.
Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian, Sreenidhi Mohanvelu, Sheeja Aravindan, Afsana Parveen Jahir Hussain, Sivasubramani Narayanan, Sabir Salim, Loganayaki Periyasamy, Natarajan Aravindan   +7 more
wiley   +1 more source

Feline‐Inspired Robot Enabled by Combustion‐Driven Actuators for Agile Motion and High‐Payload Obstacle Traversal

Advanced Science, EarlyView.
Inspired by nature's competitive maneuvers, this study introduces a combustion‐driven soft actuator that powers a multi‐modal “Jump‐and‐Fly Catbot” (JFC). With millisecond response, high‐force output (over 70 times its weight) and precise control (error within 5%), the robot can jump, fly, hover, and escape from challenging environments, achieving ...
Hongkuan Ma, Yang Yang, Zhiguo He, Hongliang Ren, Pengcheng Jiao   +4 more
wiley   +1 more source

Rock breaking performance of the newly proposed unsubmerged cavitating abrasive waterjet

International Journal of Mining Science and Technology, 2023
Chenxing Fan, Haitao Zhang, Yong Kang, Hanqing Shi, Deng Li   +4 more
semanticscholar   +1 more source

Pan‐3D Genome Analysis Reveals the Roles of Structural Variation in Chicken Chromatin Architectures, Domestication and Production Traits

Advanced Science, EarlyView.
This study firstly presents a comprehensive and high‐resolution pan‐3D genome resource in chicken. Our findings reveal the role of structural variations in 3D genome architectures, and how they influence the domestication process and production traits at the 3D genome level.
Zhen Zhou, Danfeng Cai, Changbin Zhao, Siyu Zhang, Jiahao Li, Zhaofeng Zhang, Shaofen Kong, Xin Yang, Xiaoli Zhou, Farhad Bordbar, Fayi Chen, Yaohuan Xu, Zhe Zhang, Lihong Gu, Zhenhui Li, Xiquan Zhang, Wen Luo, Jingting Shu, Bolin Cai, Qinghua Nie   +19 more
wiley   +1 more source

Analysis on Fluid-Solid-Thermal Coupling Field in Rock Breaking Under Composite Impact Loads Based on Simulation Model

Shiyou jixie
In order to reveal the rock-breaking mechanism of full-size PDC bit under composite impact loads,from the perspective of temperature,a simulation model of fluid-solid-thermal coupling in rock breaking of PDC bit under composite impact loads was built ...
Cao Jifei, Zou Deyong, Li Cheng, Wang Hanxiang, Che Jiaqi, Zhang Weiqiang, Huang Zhe   +6 more
doaj  

Downhole Environment Modeling and Multi-field Coupling Analysis of Microwave Rock Breaking

Shiyou jixie, 2019
The current researches on microwave rock breaking are mostly at the micro level based on the ideal resonant cavity model, which is quite different from the actual downhole microwave rock breaking in drilling applications.
Hu Liang, Xue Zhanfeng
doaj  

Two‐Dimensional La2CoO4 Perovskite Oxide Enabled by Phonon‐Resonance‐Driven Exfoliation for High‐Performance Gas Sensing

Advanced Science, EarlyView.
Few‐layer La2CoO4 nanosheets are produced via phonon‐resonance‐assisted cleavage of the rock‐salt layers in the Ruddlesden‐Popper structure under the 20 kHz resonance condition, enabling controlled exfoliation into ultrathin sheets. The nanosheets show improved gas‐sensing capability, delivering an 86.67% response to 1 ppm NO2 at room temperature ...
Yi Liang, Zhong Li, Tao Tang, Yinfen Cheng, Xinyi Hu, Jinghao Zhuang, Ang Li, Yaoyang Liu, Qingguo Feng, Mingyuan Wang, Guiwu Liu, Guanyu Chen, Fanli Meng, Jian Zhen Ou   +13 more
wiley   +1 more source

Simulation study of rock-breaking performance of TBM cone-shape cutterhead under different tunneling parameters in spiral tunnel. [PDF]

Sci Prog
Lin L, Liu K, Ji Z, Qi M, Wang J, Xiao J, Xia Y, Yang M.   +7 more
europepmc   +1 more source

Compensatory Interplay Between Clarin‐1 and Clarin‐2 Deafness‐Associated Proteins Governs Phenotypic Variability in Hearing

Advanced Science, EarlyView.
Functional compensation between clarin‐1 and clarin‐2 in cochlear hair cells. Hearing loss associated with CLRN1 mutations shows striking phenotypic variability; however, the underlying mechanisms remain poorly understood. This study reveals that clarin‐1 and clarin‐2 function cooperatively in cochlear hair cells to sustain mechanoelectrical ...
Maureen Wentling, Aïda Yakhlef Sanchez, Nicolas Thelen, Müge Senarisoy, Maria Hogg, Steven Condamine, Andrea Lelli, Emilia Wysocka, Pranav Patni, Sandrine Vitry, Kerem Yasin Yildizhan, Sébastien Le Gal, Sylvie Nouaille, Michael R. Bowl, Marc Thiry, Didier Dulon, Sedigheh Delmaghani, Aziz El‐Amraoui   +17 more
wiley   +1 more source