Results 101 to 110 of about 141,433 (299)

Multi‐Enzyme Mimetic Molybdenum Nitride Nanozymes Reshape Subgingival Microenvironment for Synergistic Periodontitis Therapy via ROS Regulation and Microbiome Remodeling

Advanced Science, EarlyView.
ABSTRACT Periodontitis, a chronic inflammatory disease initiated and sustained by plaque microorganisms and host immune response, remains an intractable oral disease and a leading cause of tooth loss worldwide. Traditional mechanical debridement and adjunctive antibiotic or antiseptic therapy often shows limited efficacy due to the complex anatomical ...
Weiyu Zhang, Zhongwei Yang, Yunfan Zhang, Longwei Wang, Xiaoyu Zhang, Jiahui Mao, Yizhi Dai, Yifan Yuan, Mingge Wang, Xin Yang, Xin Yu, Jing Liu, Chunying Chen   +12 more
wiley   +1 more source

INFLUENCE OF THE BOTTOM BOREHOLE ZONE ENVIRONMENT ON THE EFFICIENCY OF ROCK BREAKING BY THE PDC CUTTER

Известия Томского политехнического университета: Инжиниринг георесурсов, 2021
Relevance. The PDC cutter reinforced rock cutting tool has proven itself as a rock cutting tool with good performance. As it is known from drilling practice, a tool of this type, with the correct technology of its application, is capable of providing high rates of penetration of wells and resource.
Vyacheslav V. Neskoromnykh, Marina S. Popova, Liu Baochang   +2 more
openaire   +1 more source

Proton FLASH Exposure Preserves Gut Commensal Microbiomes and Spares Intestinal Stem Cells

Advanced Science, EarlyView.
This study highlights the role of Proton FLASH abdominal irradiation in sparing of intestinal stem cells and preservation of key gut microbial population resulting minimization of radiation toxicity in intestinal epithelium in mice. Our findings support the potential of Proton FLASH to improve the therapeutic ratio for abdominal radiation exposure ...
Rishi Man Chugh, Payel Bhanja, Emily Schueddig, Jufri Setianegara, Yuting Lin, Kenny Guida, Shujah Rehman, Stacey Krepel, Devin Koestler, Ronald C. Chen, Katherine L. Cook, Subhrajit Saha   +11 more
wiley   +1 more source

Design of Safe and Efficient Adenine Base Editors via Protein Language Model Screening for Osteoarthritis Treatment

Advanced Science, EarlyView.
ABSTRACT Base editors enable precise genome modification and have emerged as a promising therapeutic approach for correcting diseases caused by single‐nucleotide variants. While the current efficient version of adenine base editors (ABEs), such as ABE8e, exhibits exceptional efficiency for A‐to‐G conversions, their clinical translation is hindered by ...
Jiawei Yao, Dalin Chen, Ziyi Zhang, Jingxuan Ren, Chengcheng Zhao, Shengfang Wang, Mengyu Shang, Dawei Jiang, Yinuo Li, Su'an Tang, Kai Li, Xiaohui Zhang, Xiaogang Wang   +12 more
wiley   +1 more source

An Experimental and Numerical Simulation Study on Rock Cutting Based on Pre-Breaking

Shiyou jixie, 2019
The design of the mixed-cutter placement can only rely on the engineering experience. The combination of experiment and numerical simulation is used to study the rock breaking force and rock breaking efficiency of the PDC cutter under different pre ...
Liu Zhong, Hou Huihui, Hu Wei
doaj  

Mechanisms underlying lateral force applied to a PDC cutter on a PDC drill bit during rotary rock breaking

Meitian dizhi yu kantan
ObjectiveTo improve the rock-breaking efficiency and durability of drill bits in the theoretical research on the optimal design of drill bits, the key is to systematically reveal both the rock-breaking mechanisms of polycrystalline diamond compact (PDC ...
Jiusen WEI, Xin HAN, Wei LIU, Deli GAO
doaj   +1 more source

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

Research on working principle and cross-track cutting characteristic of the axis-tilted rock-breaking tool

Advances in Mechanical Engineering, 2019
Concentric-track cutting method of a conventional polycrystalline diamond compact bit makes the bit suffer from inadequate rock-penetrating capacity and severely hinders the improvement of rock-breaking efficiency.
Haitao Ren, Yingxin Yang, Chunxiao Zhou, Shiwei Niu, Chunliang Zhang, Kuilin Huang   +5 more
doaj   +1 more source

Mechanoadaptation via Myosin Cytoplasmic Redistribution Protects Circulating Tumor Cells From Shear‐induced Death During Hematogenous Dissemination

Advanced Science, EarlyView.
This study investigates how CTCs survive varying shear stress during hematogenous metastasis. We uncover a self‐protection mechanism, by which non‐adherent CTCs adapt to high shearing milieu through accumulated cytoplasmic myosin‐mediated disruption of myosin‐actin binding, attenuating force transmission into chromatin to protect CTCs from shear ...
Cunyu Zhang, Qianchun Wang, Keming Li, Guanshuo Hu, Ying Xin, Kai Tang, Bing Hu, Pengyu Du, Renwei Mao, Baohua Ji, Youhua Tan   +10 more
wiley   +1 more source

Search for Dark Matter WIMPs using Upward Through-going Muons in Super-Kamiokande

, 2004
We present the results of indirect searches for Weakly Interacting Massive Particles (WIMPs) with 1679.6 live days of data from the Super-Kamiokande detector using neutrino-induced upward through-going muons.
A. Habig, A. Habig, A. K. Ichikawa, A. Kibayashi, A. Minamino, A. Okada, A. Sarrat, A. Suzuki, A. T. Suzuki, C. Caso, C. K. Jung, C. Mauger, C. McGrew, C. Mitsuda, C. Saji, C. W. Sterner, C. W. Walter, C. Yanagisawa, D. Casper, D. Cline, D. Kielczewska, D. Takemori, D. Turcan, D. W. Liu, D. L. Anderson, E. Blaufuss, E. Kearns, E. Sharkey, G. Guillian, G. W. Sullivan, G. R. Blumenthal, H. I. Kim, H. Ishino, H. K. Seo, H. Maesaka, H. Okazawa, H. Takeuchi, H. W. Sobel, I. Kato, I. T. Lim, J. A. Goodman, J. G. Learned, J. Hill, J. Kameda, J. L. Stone, J. P. Cravens, J. Shirai, J. Y. Kim, J. Yoo, J. Zalipska, J. L. Tonry, K. Hayashi, K. Inoue, K. Ishihara, K. K. Shiraishi, K. Kaneyuki, K. Kobayashi, K. Miyano, K. Nakamura, K. Nishijima, K. Nishikawa, K. Nitta, K. S. Ganezer, K. Scholberg, K. Washburn, L. R. Sulak, M. Ambrosio, M. B. Smy, M. D. Messier, M. Earl, M. Glück, M. Goldhaber, M. Hasegawa, M. Ishitsuka, M. Koshiba, M. Malek, M. Miura, M. Morii, M. Nakahata, M. R. Vagins, M. Sakuda, M. Shiozawa, M. Takita, M. Yoshida, M. M. Boliev, N. Sakurai, O. Suvorova, P. Ullio, R. Bernabei, R. Gran, R. J. Wilkes, R. Nambu, R. Nishimura, R. Svoboda, R. W. Ellsworth, S. B. Kim, S. Dazeley, S. Desai, S. Fukuda, S. Hatakeyama, S. Matsuno, S. Mine, S. Moriyama, S. Nakayama, S. Tasaka, S. Ueda, S. Yamada, S. Yamamoto, S. Yoshida, T. Barszczak, T. Harada, T. Hasegawa, T. Hashimoto, T. Inagaki, T. Ishida, T. Ishii, T. Ishizuka, T. Iwashita, T. J. Haines, T. Kajita, T. Kato, T. Kobayashi, T. Maruyama, T. Morita, T. Nakaya, T. Namba, T. Ooyabu, T. Sasaki, T. Shibata, T. Toshito, W. E. Keig, W. Gajewski, W. R. Kropp, W. Wang, Y. Ashie, Y. Choi, Y. Fukuda, Y. Gando, Y. Hayato, Y. Itow, Y. Kajiyama, Y. Koshio, Y. Nagashima, Y. Nakajima, Y. Obayashi, Y. Oyama, Y. Suzuki, Y. Takeuchi, Y. Totsuka, Y. Watanabe   +149 more
core   +1 more source