Results 111 to 120 of about 140,547 (299)

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC‐Derived Cortical Organoids

Advanced Science, EarlyView.
A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid‐beta and phospho‐Tau aggregation, neuronal hyperexcitability, and synapse loss. Single‐cell RNA‐seq reveals aberrant pathways in excitatory and inhibitory neurons.
Sergio R. Labra, Jadon Compher, Akhil Prabhavalkar, Mireya Almaraz, Claudia Cedeño Kwong, Christine Baal, Maria Talantova, Nima Dolatabadi, Julian Piña‐Sanz, Yubo Wang, Leonard Yoon, Swagata Ghatak, Zi Gao, Yuting Zhang, Dorit Trudler, Lynee Massey, Wei Lin, Anthony Balistreri, Michael Bula, Nicholas J. Schork, Tony S. Mondala, Steven R. Head, Jeffery W. Kelly, Stuart A. Lipton   +23 more
wiley   +1 more source

Rock Breaking Mechanisms and Heat Generation Analysis on High Temperature Rocks in Deep Wells

Shiyou jixie, 2021
In order to improve the rock breaking efficiency of PDC cutter in high temperature formations in deep wells, granite and sandstone are heated respectively to different temperatures to simulate the high temperature rocks at the deep bottom hole.
Chen Hao, Li Bangrun, Cai Can, Xie Song, Cao Yulei, Yang Yingxin   +5 more
doaj  

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

Advanced Science, EarlyView.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying, Hangping Fan, Yunhe Wang, Ruhong Jiang, Dongsheng Cai, Hui Cheng, Hao Wang, Chenyang Jiang, Ping Liang   +8 more
wiley   +1 more source

Numerical simulation of optimal jet angle of water jet assisted disc cutter rock breaking

Meitan kexue jishu
In order to solve the problems of difficulty in tunneling, serious tool loss and low efficiency of breaking ultra-high strength rock encountered in the construction process of traditional hob, high-pressure water jet has become a new method to improve ...
Anxin WANG, Yiqiang LU, Sheng ZHANG, Jianhong MA, Zhanbiao YANG, Hongyun FAN   +5 more
doaj   +1 more source

Study on Rock Breaking Efficiency of Non Planar PDC Teeth

Academic Journal of Science and Technology
 In order to explore the law of rock breaking efficiency of existing non planar teeth in sandstone, indoor single tooth rock breaking experiment and numerical simulation of rock breaking are carried out for planar teeth, sharp circular teeth and axe teeth, and the effects of different eating depth and rake angle on rock breaking efficiency of PDC teeth
openaire   +1 more source

The chemical bond as an emergent phenomenon

, 2017
We first argue that the covalent bond and the various closed-shell interactions can be thought of as symmetry broken versions of one and the same interaction, viz., the multi-center bond.
Golden, Jon C., Ho, Vinh, Lubchenko, Vassiliy   +2 more
core   +1 more source

Stepwise Regulation of Cellular Oxidative Stress via Conductive‐Piezoelectric Integrated Microstructured Conduits for Enhanced Nerve Regeneration

Advanced Science, EarlyView.
This study presents a conductive‐piezoelectric integrated microstructured conduit for peripheral nerve regeneration. The conduit combines reduced graphene oxide with a piezoelectric nanofiber membrane, enhancing nerve repair through physical guidance, oxidative stress inhibition, and ultrasound‐activated electrical stimulation.
Dong Zhou, Mengxuan Bian, Lingyu Wei, Binghuang Yao, Qi Chen, Lan Xiao, Jing He, Jian Zhang, Yulin Li, Libo Jiang   +9 more
wiley   +1 more source

A Study on the Effects of Hob Temperature on the Rock-Breaking Characteristics of Sandstone Strata

Applied Sciences
To explore the effect of hob temperature on the rock-breaking characteristics of full-section tunnel boring machines (TBMs) in sandstone strata, high-temperature furnace heating experiments of sandstone and physical and mechanical experiments at room ...
Yun-Gui Pan, You-Liang Chen, Xi Du, Hui-Dong Tong, Fei-Yu Tang, Xiao-Jian Wu, Su-Ran Wang, Shao-Ming Liao, Bin Peng   +8 more
doaj   +1 more source

Effect of antenna size on rock mass breaking efficiency under open-ended microwave treatment

Thermal Science
Antenna size is a critical factor influencing the efficiency of open-ended microwave rock-breaking. An electromagnetic-thermal-mechanical coupling model was developed to systematically investigate the influence of antenna size on the temperature distribution within the rock mass under microwave treatment.
Shou-Ning Xue, Yang Zhang, Jun Luo, Fei-Long Xu, Ben-Gao Yang   +4 more
openaire   +1 more source

INFLUENCE OF THE BOTTOM BOREHOLE ZONE ENVIRONMENT ON THE EFFICIENCY OF ROCK BREAKING BY THE PDC CUTTER

Известия Томского политехнического университета: Инжиниринг георесурсов, 2021
Relevance. The PDC cutter reinforced rock cutting tool has proven itself as a rock cutting tool with good performance. As it is known from drilling practice, a tool of this type, with the correct technology of its application, is capable of providing high rates of penetration of wells and resource.
Vyacheslav V. Neskoromnykh, Marina S. Popova, Liu Baochang   +2 more
openaire   +1 more source