Results 111 to 120 of about 839,776 (287)

Sex Differences in Children's Motivation and Action Patterns for Climbing as Behavioral Relicts of Ancestral Sexual-Size Dimorphism

Evolutionary Psychology
Four studies investigated sex differences in children's motivation and action patterns for climbing playground structures and a gymnasium rock wall to assess any influence of ancestral sexual-size dimorphism limiting tree-climbing agility.
Richard G. Coss, Victor K. Geisler, Michael Newmann   +2 more
doaj   +1 more source

Molecular Glue Degraders Enhance CAPRIN1‐Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease

Advanced Science, EarlyView.
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung, Xu Wang, Bin Liu, Raktim Roy, Nancy Jaiswal, Ratan K. Rai, Yuichiro Takagi, Cen Gao, Lifan Zeng, Ho‐Yin Lo, Reagan K. Wohlford, Ryan K. Higgins, Bruce T. Lamb, Anantha Shekhar, Anita C. Bellail, Chunhai Hao   +15 more
wiley   +1 more source

ALEXANDER PIRATINSKY – A LEADING SPECIALIST IN ROCK CLIMBING IN RUSSIA AND THE WORLD

Физическая культура. Спорт. Туризм. Двигательная рекреация, 2020
A. E. Piratinsky is one of the leading experts in Russia and the world on the theory, methods of training athletes and organizing sports events in rock climbing of the highest rank.
Lyudmila Vladimirovna Moiseeva
doaj  

Impact of Site Decision Variables on Visitors' Choices of State and Federal Rock Climbing Areas

, 2005
The purposes of this study were to evaluate the factors important to rock climbers when choosing to visit state or federally managed rock climbing areas. In comparing these sites, which factors differentiate site choices? Are these factors similar?
Georgiade, Nicholas Charles
core  

A Dual‐Membrane Biomimetic Nanoplatform Enables Triple‐Modal Therapy Against SARS‐CoV‐2 Through Viral Decoy, Inflammation Neutralizing, and Intracellular RNAi

Advanced Science, EarlyView.
[A&T]MLN is a triple‐modal nanoplatform with siRNA‐loaded LN coated with hybrid ACE2/macrophage membrane. It blocks viral entry, neutralizes IL‐6/IL‐1β/TNF‐α, and delivers siRNA to suppress viral replication. In a murine lung injury model, it attenuates inflammation, offering a multi‐pronged strategy against SARS‐CoV‐2 variants and hyperinflammation ...
Hui Li, Bohan Zhang, Chao Shang, Yi Li, Te Zhao, Shengya Liu, Dan Liu, Junwei Che, Cuiling Zhang, Pinghui Wu, Wenjie Yang, Junjie Ding, Yuhua Ran, Yanan Zhai, Haihua Xiao, Jing Gao, Xiao Li, Chunsheng Gao, Lin Li, Zhiping Li   +19 more
wiley   +1 more source

Rock wall climbing

, 2000
Rock wall climbing at the Welcome Back BBQ at the University College of the Cariboo Kamloops ...

core  

Expanding Genetic Code to Generate Human Brain Organoids with Both Vasculature and Microglia‐Like Cells

Advanced Science, EarlyView.
Using genetic code expansion, we engineered vascularized human cerebral organoids (vhCOs) with microglia‐like cells and blood‐brain barrier features. vhCOs recapitulate neurovascular interactions, regional identities, and neuronal subtypes resembling the fetal brain.
Haishuang Lin, Yaqing Wang, Hu Du, Yuxin Qin, Haoyu Zhang, Peng Wang, Lin Wei, Jianhua Qin   +7 more
wiley   +1 more source

Reverence for Rock: The Effect of Institutionalized Modalities on the Motility of Women in Rock Climbing [PDF]

This thesis begins with an overview of the history of rock climbing that presents the opportunity to evaluate rock climbing as a religion/religious act in Section 2.
Settimo, Sarah S.
core   +3 more sources

Rock climbing on Ferguson Creek

, 2009
FC002Ferguson Creek Canyon is a popular spot for rock ...
Craig Denton
core  

SIRT5‐Mediated Desuccinylation of ACAA2 Protects Against Calcium Oxalate‐Induced Kidney Injury by Regulating Fatty Acid Oxidation to Suppress Mitochondrial Oxidative Injury and Ferroptosis

Advanced Science, EarlyView.
The SIRT5/ACAA2 axis maintains lipid metabolic homeostasis in RTECs by promoting ACAA2 desuccinylation and preserving its stability and enzymatic activity, thereby sustaining FAO and limiting PUFA and PUFA‐containing phospholipid accumulation. Under CaOx stress, SIRT5 downregulation impairs FAO, promotes oxidative stress and ferroptosis, and enhances ...
Qinhong Jiang, Caitao Dong, Yuchen Liu, Yuanquan Lou, Wenlong Lin, Sheng Li, Ziqi He   +6 more
wiley   +1 more source