Results 161 to 170 of about 839,776 (287)

Effectiveness of indoor rock climbing and bouldering as treatment for depression - a systematic review. [PDF]

BMC Psychiatry
Larsson R, Larsson A, Nordeman L.
europepmc   +1 more source

Adaptive Cellular Responsiveness to Electrical Stimulation at the Skin‐Electrode Interface

Advanced Science, EarlyView.
This study presents an adaptive bioelectronic response in which sustained electrical stimulation (ES) upregulates voltage‐gated calcium channels (VGCCs) and enhances cellular sensitivity to subsequent ES at the skin‐device interface. VGCC‐associated adaptive sensitization promotes regenerative wound‐healing responses in vivo, including accelerated ...
Yeon Jae Chang, Soon Jin Choi, Khandoker Asiqur Rahaman, Tae Kyoung Lee, Gwangbin Lee, Jaeyeon Jun, Hyeon‐Jeong Lee, Hophil Min, Hojeong Jeon, Jung Keun Hyun, Hyung‐Seop Han, Jimin Park   +11 more
wiley   +1 more source

The Effect of Blood Flow Restriction Training on Rock Climbing Performance, Forearm Blood Oxygenation and Cardiovascular Responses. [PDF]

Eur J Sport Sci
Mckellar BJ, Burr JF.
europepmc   +1 more source

Development‐Informed Microsphere Assemblies Enable Spatiotemporally Programmed Bone–Vascular Organoid‐Like Constructs for Large Bone Defect Repair

Advanced Science, EarlyView.
Single‐cell‐guided prioritization of BMP4 and VEGFA is combined with temporally programmed BMSCs and a Matrigel‐free GelMA/PEO/bioactive‐glass assembled‐microsphere matrix to generate bone–vascular organoid‐like constructs. The platform coordinates osteogenic differentiation, endothelial activation, vascular‐like microchannel formation, and ...
Renhao Ni, Xinyi Shi, Tong Zhu, Guanrong Li, Lei Chang, Shengtao Li, Jingyi Chi, Chen Shi, Zeming Hu, Rong Xu, Yingchun Zhu, Yang Luo, Yichen Chen, Fan Yang, Yabin Zhu   +14 more
wiley   +1 more source

National Trends in Rock Climbing Injuries: A 10-Year Epidemiological Analysis of US Emergency Department Data (2014-2023). [PDF]

JB JS Open Access
Lin JQ, Khera JS, Furtado N, Saiz AM.
europepmc   +1 more source

Matrix Stiffness Promotes Tumor Metastasis by Triggering Recycling Endosome‐Mediated YY1 Nuclear Translocation and Transcriptional Activity

Advanced Science, EarlyView.
In stiff extracellular matrix (ECM), integrin αVβ3 transduces mechanical cues of ECM stiffness to promote recycling endosome formation, creating a signaling platform for yin yang 1 (YY1)/p21‐activated kinase 4 (PAK4) binding, but not in soft ECM. Then, this triggers PAK4‐mediated YY1 phosphorylation at S118, subsequent YY1 nuclear translocation and ...
Fuqiang Zhao, Xinpeng Wen, Jingyi Liu, Hongqiang Yu, Tianzhu Cui, Makoto Miyagishi, Vivi Kasim, Shourong Wu   +7 more
wiley   +1 more source

Pharmacokinetic Tuning Redirects β‐Lapachone From NQO1 Bioactivation to Vimentin‐Targeted Oxidation in Cancer

Advanced Science, EarlyView.
Pharmacokinetic tuning acts as a programmable mechanistic switch for β‐lap. Sustained low‐concentration exposure redirects β‐lap from NQO1 bioactivation to direct oxidation of vimentin, driving disulfide crosslinking, proteasomal overload and ferroptosis.
Lei Dou, Huiqin Liu, Kaixin Wang, Yi Xia, Zhidong Chen, Feng Qian   +5 more
wiley   +1 more source

Current sex and age patterns of rock climbing-related injuries treated in emergency departments. [PDF]

Front Sports Act Living
Madsen A, Pezzullo L, Nixon RM, Vincent KR, Vincent HK.   +4 more
europepmc   +1 more source

Stable Magnetic Nanodomains Engineered Via Ga+‐ion Irradiation For Deterministic Sequential Switching

Advanced Electronic Materials, EarlyView.
Tiny magnetic regions separated by domain walls can store data, but controlling them precisely is difficult. We use focused ion beams to create nanoscale “anisotropy wells” that pin these walls from both sides. This bidirectional pinning holds domains stable in either direction, even with no field applied.
Gijs W.A. Simons, Rik F.J. van Haren, Bert Koopmans   +2 more
wiley   +1 more source

Pediatric Climbers Experience More Upper Extremity Injuries, Geriatric Climbers More Lower Extremity Injuries, and Increased Shoulder Trauma Associated With Male Individuals in an Emergency Department Analysis of Rock Climbing-Associated Musculoskeletal Injuries. [PDF]

Arthrosc Sports Med Rehabil
Alexio TZ, Lee PM, Kim NN, Agonias KB, Obana KK, Luzzi AJ, Weiss JM.   +6 more
europepmc   +1 more source