Results 21 to 30 of about 2,680,418 (361)
BiomedicinesBackground: Lung adenocarcinoma (LUAD) remains a leading cause of cancer-related mortality despite advances in treatments, necessitating more effective therapeutic strategies.
Jialu Ma +4 more
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Expressions of Rock Joint Roughness Coefficient Using Neutrosophic Interval Statistical Numbers
Symmetry, 2017 In nature, the mechanical properties of geological bodies are very complex, and their various mechanical parameters are vague, incomplete, imprecise, and indeterminate.
Jiqian Chen, Jun Ye, S. Du, Rui Yong
semanticscholar +1 more source
Characterizing the Tumor Microenvironment and Its Prognostic Impact in Breast Cancer
CellsThe tumor microenvironment (TME) is crucial in cancer development and therapeutic response. Immunotherapy is increasingly recognized as a critical component of cancer treatment.
Wenjuan Zhang +3 more
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Numerical investigations of rock bridge effect on open pit slope stability
Journal of Rock Mechanics and Geotechnical Engineering, 2019 In this study, the effect of rock bridges on rock slope stability was investigated by incorporating non-persistent joint networks in numerical models, and the critical profiles of an open pit mine were analysed.
C. Romer, M. Ferentinou
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LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Machine Learning with ApplicationsThe joint roughness coefficient (JRC) is critical to evaluate the strength and deformation behavior of joint rock mass in rock engineering. Various methods have been developed to estimate JRC value based on the statistical parameter of rock joints.
Yuyang Zhao, Hongbo Zhao
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Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Shear mechanical properties and empirical formula of infilled rock joints
Yantu gongcheng xuebaoThe investigation of the shear mechanical properties of infilled rock joints is of significant importance for the stability assessment of engineering rock formations.
GAO Fuzhou 1, ZHANG Junyun 1, LUO Xiaolong 1, ZHAI Kexiang 1, ZHANG Le 2, HUANG Rui 1, 2, WU Xiaofei 1
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DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling
FEBS Open Bio, EarlyView.Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang +7 more
wiley +1 more source
Arthritis Care &Research, EarlyView.Objective Sjögren's disease is an autoimmune disorder that can impact multiple organ systems, including the peripheral nervous system (PNS). PNS manifestations, which can exist concurrently, include mononeuropathies, polyneuropathies, and autonomic nervous system neuropathies.
Anahita Deboo +88 more
wiley +1 more source