Results 31 to 40 of about 464,941 (308)

Characterizing the Tumor Microenvironment and Its Prognostic Impact in Breast Cancer

Cells
The tumor microenvironment (TME) is crucial in cancer development and therapeutic response. Immunotherapy is increasingly recognized as a critical component of cancer treatment.
Wenjuan Zhang, Alex Lee, Amit K. Tiwari, Mary Qu Yang   +3 more
doaj   +1 more source

Numerical investigations of rock bridge effect on open pit slope stability

Journal of Rock Mechanics and Geotechnical Engineering, 2019
In this study, the effect of rock bridges on rock slope stability was investigated by incorporating non-persistent joint networks in numerical models, and the critical profiles of an open pit mine were analysed.
C. Romer, M. Ferentinou
doaj   +1 more source

Experimental studies on the shear resistance of original coal-shale joint [PDF]

, 2017
Purpose. Experimental study and theoretical modeling of the shear resistance of original coal-shale joint. Methods. A two-segment model was developed to describe the shear resistance-shear displacement curves obtained from the direct shear tests of ...
Dong, H, Guo, B, Wang, L
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

岩盤不連続面の開口状況の定量的評価とそのせん断強度式への適応性 [PDF]

, 1999
The factors of discontinuity plane which affect the shear behavior of rock joint are the strength of intact rock, roughness, aperture etc. In these factors, there is many researches in related with the roughness.
Kusumi Harushige, Nakamura Hitoshi, Nishida Kazuhiko, Sakai Takashi, 中村 均史, 楠見 晴重, 西田 一彦, 酒井 崇   +7 more
core   +1 more source

Micromechanical basis for shear strength of rock discontinuities [PDF]

, 2014
The theoretical basis for evaluating shear strength in rock joints is presented and used to derive an equation that governs the relationship between tangential and normal stress on the joint during situations of slippage between the joint faces.
Galindo Aires, Rubén Ángel, Olalla Marañón, Claudio, Serrano Gonzalez, Alcibiades   +2 more
core   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Uncertainty quantification based on symbolic regression and probabilistic programming and its application

Machine Learning with Applications
The joint roughness coefficient (JRC) is critical to evaluate the strength and deformation behavior of joint rock mass in rock engineering. Various methods have been developed to estimate JRC value based on the statistical parameter of rock joints.
Yuyang Zhao, Hongbo Zhao
doaj   +1 more source

The Shear Strength Formula Including Joint Aperture and Roughness for Natural Rock Joint [PDF]

, 2003
In this paper, using natural rock joint specimens and direct shear-testing machine, the influences of joint aperture and roughness on shear behavior of rock joint are experimentally investigated. The index of joint roughens is applied on JRC, and in case
Kusumi Harushige, Sugino Tomomichi, Yamada Ryousuke, 山田 亮介, 杉野 友通, 楠見 晴重   +5 more
core   +1 more source

Clinical Practice Guideline for Evaluation and Management of Peripheral Nervous System Manifestations in Sjögren's Disease

Arthritis Care &Research, EarlyView.
Objective Sjögren's disease is an autoimmune disorder that can impact multiple organ systems, including the peripheral nervous system (PNS). PNS manifestations, which can exist concurrently, include mononeuropathies, polyneuropathies, and autonomic nervous system neuropathies.
Anahita Deboo, Robert Fox, Katherine M. Hammitt, Julie Frantsve‐Hawley, Matthew C. Baker, Stamatina Danielides, Eduardo De Sousa, Brent P. Goodman, Jennifer K. King, Steven Mandel, Ghaith Noaiseh, Pantelis P. Pavlakis, George Sarka, R. Hal Scofield, Arun Varadhachary, Daniel J. Wallace, Matt Makara, Nancy Carteron, Steven Carsons, in collaboration with the Consensus Expert Panel (CEP) members, G. Alden Adkins, Brittany Adler, Hossein Ansari, Senada Arabelovic, Alan Baer, Denis Balaban, Shamik Bhattacharyya, Evelyn Bromet, Krishna Chaganti, Kamal Chemali, Melissa Cortez, Schartess Culpepper, Paul Dellaripa, Dana Direnzo, Daniel El Bogdadi, Robert Fearon, Mehrnez Fischbach, Judi Furlong, Christopher Gibbons, Rachael Gordon, Thomas Grader Beck, Syed Haider, Larry Hollenbeck, Chadwick R. Johr, Stuart S. Kassan, Brian King, Octavia Kincaid, Eugene Kissin, Vasileios Kyttaris, Lindsay Lally, Brandon M. Law, Janet Lewis, Scott M. Lieberman, Amanda Lusa, Joseph Lutt, Rashmi Maganti, Arthur M. Mandelin, Sara McCoy, Kerry Neall, Timothy Niewold, Anne Louise Oaklander, Ruben A. Peredo‐Wende, Lynn Petruzzi, Mark A. Porter, Guada Respicio Duque, Tania Reyna, Nathaniel M. Robbins, Elliot D. Rosenstein, Laura Rosow, Breanna Ruthrauff, Amit Sachdev, Nora Sandorfi, Sarah Schafer, Elena Schiopu, Chokkalingam Siva, Daniel Small, Sara M. Stern, Lauren Stiles, Susan Stoddard, Jinny Tavee, Donald Thomas, Edward L. Treadwell, Nagagopal Venna, Steven Vernino, Frederick B. Vivino, Brittany Weber, Sepideh Yadollahi, Huiying Yu, Scott Zashin   +88 more
wiley   +1 more source