Results 41 to 50 of about 120,559 (311)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Experimental study on damage identification of single structure plane dangerous rock masses based on constant micromotion

工程科学学报
The dynamic parameters of the dangerous rock mass can represent the damage to the structural plane between the dangerous rock mass and the bedrock.
Zhixiang WU, Mowen XIE, Xiaoyong ZHANG, Lei ZHANG, Jianhui WANG, Xin CHEN   +5 more
doaj   +1 more source

A brief introduction to disaster rock mass mechanics

Geohazard Mechanics, 2023
Rock mass mechanics can be classified into engineering rock mass mechanics and disaster rock mass mechanics based on science and application. Their conception, object, scientific essence and application were elaborated.
Yangsheng Zhao, Zijun Feng
doaj   +1 more source

Motion of rock masses on slopes

Geologija, 2006
This paper shows the different ways of how rock masses (stones, rocks, and blocks) move along slopes and for each different way of motion (free fall, bouncing, rolling, sliding, slowing down, lubrication, fluidization)adequatedynamicequationsaregiven.Knowingthe kinematics and dynamics of travelling rock masses is necessary for mathematical modeling of ...
Urška Petje, Matjaž Mikoš, Bojan Majes   +2 more
openaire   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Numerical Simulation of Long-Term Deterioration of Rock Mass Supported by Shotcrete Lining

Frontiers in Earth Science, 2022
The deterioration of rock mass and shotcrete lining has major consequences on the long-term performance of tunnels in the weak rock mass. In this study, the long-term behavior of rock mass and shotcrete in tunnels was simulated by using the three ...
Chao Kong, Chao Kong, Haiyan Wang, Kai Zhao, Xinqiang Gao, Xinqiang Gao   +5 more
doaj   +1 more source

Mechanisms of failure of jointed rock masses and the behaviour of steep slopes [PDF]

, 1998
The geomorphological behaviour of steep jointed rock slopes has been studied using distinct element method computer models. In order to model steep slopes effectively, methodologies need to be combined from the studies of environmental modellers ...
Kimber, Owen Graham
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source