Results 51 to 60 of about 87,679 (264)

Conformational Switching of Proteins on Material Surfaces Enabled by Peptide‐Oriented Adsorption

open access: yesAdvanced Functional Materials, EarlyView.
Responsive biointerfaces could be achieved using conformationally responsive proteins; however, their interconversion can be lost upon surface adsorption. Herein, we demonstrate that the incorporation a Au binding peptide into calmodulin allows for binding control on Au wherein the protein retains conformational switching. This capability was confirmed
Sakthirupini Ramamurthy   +7 more
wiley   +1 more source

Nanofiber‐Supported Decellularized Matrix Membrane Creates a Biomimetic Biochemical and Biophysical Niche for Intestinal Organoid Epithelium

open access: yesAdvanced Healthcare Materials, EarlyView.
A nanofiber‐supported decellularized extracellular matrix (NaDE) membrane recreates key biochemical and mechanical features of native intestinal tissue. This platform enables the formation of a more physiologically relevant intestinal epithelium, enhancing stem cell maintenance and promoting diverse cell differentiation.
Jaeseung Youn   +7 more
wiley   +1 more source

Algorithmic Geology: Tackling Methodological Challenges in Applying Machine Learning to Rock Engineering

open access: yesGeosciences
Technological advancements have made rock engineering more data-driven, leading to increased use of machine learning (ML). While the use of ML in rock engineering has the potential to transform the industry, several methodological issues should first be ...
Beverly Yang   +3 more
doaj   +1 more source

Flash Assembloids: A Rapid Biofabrication of a Platform for Modeling Early Glioblastoma Invasion at the Glioblastoma–Brain Organoid Interfaces

open access: yesAdvanced Healthcare Materials, EarlyView.
This study presents a bioengineered assembloid (ASM) system combining glioblastoma (GBM) cells in oxidized alginate (OA) microgels with dorsal organoids (DOs). This model simulates brain tumor‐host interactions, revealing enhanced GBM invasion, altered gene expression, and aggressive infiltration patterns, demonstrating ASM as a valuable platform for ...
Chao Liang   +17 more
wiley   +1 more source

Influence of rock mass properties and powder factor on the fractal dimension of the natural rock mass blocks during blasting

open access: yesDiscover Geoscience
The rock mass fragmentation in discontinuous rock mass is a concern issue in rock mass blasting. The purpose of the study is to find out the influencing parameters of rock mass and blast design in degree of fragmentation of natural block during blasting.
Ajay Pratap Singh Tomar   +3 more
doaj   +1 more source

Evaluation of rock mass deformability using empirical methods – A review

open access: yesUnderground Space, 2017
Evaluation of rock mass deformability is an important but very challenging task in the analysis and design of underground structures in rock. Although various empirical (correlation) methods have been developed for determining the deformation modulus of ...
Lianyang Zhang
doaj   +1 more source

A Rapid Method of the Rock Mass Surface Reconstruction for Surface Deformation Detection at Close Range

open access: yesSensors, 2020
Characterizing the surface deformation during the inter-survey period could assist in understanding rock mass progressive failure processes. Moreover, 3D reconstruction of rock mass surface is a crucial step in surface deformation detection.
Qijun Hu   +6 more
doaj   +1 more source

Cellular Responses to Mechanical Cues Across Scales: From Fundamental Insights to Translational Potential

open access: yesAdvanced Healthcare Materials, EarlyView.
This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz   +9 more
wiley   +1 more source

A Modular Liver–Microbial Microfluidic Platform to Evaluate Therapeutic and Adverse Effects of Microbial Metabolites

open access: yesAdvanced Healthcare Materials, EarlyView.
This study introduces a modular microfluidic platform that connects liver cells with live microbes to mimic key aspects of the gut–liver interaction in steatosis. Using this system, both microbial metabolites and live bacteria significantly reduced fat accumulation in liver cells, but live microbes triggered inflammation and broader metabolic changes ...
Hsih‐Yin Tan   +7 more
wiley   +1 more source

Effects of Randomness of Bidirectional Ground Motion on the Fuzzy Reliability of Toppling Perilous Rock Mass

open access: yes工程科学与技术, 2023
Perilous rock mass is highly susceptible to collapse disasters under seismic actions. To calculate the stability of toppling perilous rock mass under bidirectional ground motion and explore the influence of ground motion randomness on the dynamic fuzzy ...
Jixu ZHANG   +3 more
doaj  

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