Results 51 to 60 of about 867,349 (301)
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
A Novel Deformation Analytical Solution and Constitutive Model for Fractured Rock Masses
Journal of Marine Science and Engineering, 2023 In order to study the deformation and stability of a fractured rock mass, existing research suggests that fracture deformation, which is usually obtained by evaluating the equivalent deformation modulus, dominates the deformation of a fractured rock mass.
Zeqi Zhu +5 more
doaj +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
工程科学学报The dynamic parameters of the dangerous rock mass can represent the damage to the structural plane between the dangerous rock mass and the bedrock.
Zhixiang WU +5 more
doaj +1 more source
Criteria for rapid sliding I.: a review of Vaiont case [PDF]
, 2010 Vaiont slide has been represented by a model of two interacting evolutive wedges. Mass conservation during the motion implies that the upper wedge transfers mass to the lower one through an internal shearing plane.
Alonso Pérez de Agreda, Eduardo +1 more
core +2 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Simulation of the support-enclosing rock mass interaction for deep mining [PDF]
, 2018 Purpose. To develop analytical model for a support-enclosing rock interaction to determine parameters for operational stability of deep mine workings while decreasing metal consumption and increasing efficient use of resources. Methods.
Kyrychenko, V, Stovpnyk, S
core +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
PHYTORECULTIVATION OF ROCK MASS DUMPS WITH APPLICATION OF PRODUCT OF UTILIZATION OF INDUSTRIAL WASTES AS A FERTILIZER [PDF]
, 2018 One of the types of man-made landscapes are dumps of spent rock mass, which, occupying significant areas of the earth's surface, change the terrain, are sources of secondary pollution of atmospheric air by dust and subsequent ...
Maznytskaya, Oksana, Pasenko, Alona
core
FEBS Open Bio, EarlyView.The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan +6 more
wiley +1 more source