Results 51 to 60 of about 868,049 (299)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Experimental study on damage identification of single structure plane dangerous rock masses based on constant micromotion

工程科学学报
The dynamic parameters of the dangerous rock mass can represent the damage to the structural plane between the dangerous rock mass and the bedrock.
Zhixiang WU, Mowen XIE, Xiaoyong ZHANG, Lei ZHANG, Jianhui WANG, Xin CHEN   +5 more
doaj   +1 more source

Numerical Simulation of Long-Term Deterioration of Rock Mass Supported by Shotcrete Lining

Frontiers in Earth Science, 2022
The deterioration of rock mass and shotcrete lining has major consequences on the long-term performance of tunnels in the weak rock mass. In this study, the long-term behavior of rock mass and shotcrete in tunnels was simulated by using the three ...
Chao Kong, Chao Kong, Haiyan Wang, Kai Zhao, Xinqiang Gao, Xinqiang Gao   +5 more
doaj   +1 more source

Criteria for rapid sliding I.: a review of Vaiont case [PDF]

, 2010
Vaiont slide has been represented by a model of two interacting evolutive wedges. Mass conservation during the motion implies that the upper wedge transfers mass to the lower one through an internal shearing plane.
Alonso Pérez de Agreda, Eduardo, Pinyol Puigmartí, Núria Mercè   +1 more
core   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

A Novel Deformation Analytical Solution and Constitutive Model for Fractured Rock Masses

Journal of Marine Science and Engineering, 2023
In order to study the deformation and stability of a fractured rock mass, existing research suggests that fracture deformation, which is usually obtained by evaluating the equivalent deformation modulus, dominates the deformation of a fractured rock mass.
Zeqi Zhu, Lan Cui, Youkou Dong, Qian Sheng, Kaiwei Tian, Zhenshan Guo   +5 more
doaj   +1 more source

Functional Connectivity Linked to Cognitive Recovery After Minor Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Patients with minor stroke exhibit slowed processing speed and generalized alterations in functional connectivity involving frontoparietal cortex (FPC). The pattern of connectivity evolves over time. In this study, we examine the relationship of functional connectivity patterns to cognitive performance, to determine ...
Vrishab Commuri, Isabella Dallasta, Ciaran Stone, Sophia Girgenti, Neda Gould, Rafael H. Llinas, Jonathan Z. Simon, Elisabeth Breese Marsh   +7 more
wiley   +1 more source

Simulation of the support-enclosing rock mass interaction for deep mining [PDF]

, 2018
Purpose. To develop analytical model for a support-enclosing rock interaction to determine parameters for operational stability of deep mine workings while decreasing metal consumption and increasing efficient use of resources. Methods.
Kyrychenko, V, Stovpnyk, S
core   +1 more source

Electrical Conductivities of Conductors, Semiconductors, and Their Mixtures at Elevated Temperatures

Advanced Engineering Materials, EarlyView.
This article presents a comprehensive review of temperature‐dependent electrical conductivity data for multiple material classes at elevated temperatures, highlighting a persistent conductivity gap between metals and semiconductors in the range of 102$\left(10\right)^{2}$– 107$\left(10\right)^{7}$ S/m. Metal–ceramic irregular metamaterials are proposed
Valentina Torres Nieto, Marcia A. Cooper
wiley   +1 more source

Impact of Pre‐Oxidation Treatments on a Recycled MgO/Steel‐Composite as Carbon Free Anode in Aluminum‐Electrolysis Environments

Advanced Engineering Materials, EarlyView.
Cermets (60 vol.% AISI 316L stainless steel, 40 vol.% recycled MgO), intended for use in aluminum electrolysis, were pre‐oxidized in three furnaces with different heating technologies and subjected to a cryolite corrosion test. The different atmospheres influenced the formation of oxide layers, which in turn affected corrosion resistance and ...
Patricia Kaiser, Felix Drechsler, Nora Brachhold, Florian Kerber, Christos G. Aneziris   +4 more
wiley   +1 more source