Results 101 to 110 of about 273,199 (309)

Geomechanical characterization of volcanic rocks using empirical systems and data mining techniques

Journal of Rock Mechanics and Geotechnical Engineering, 2018
This paper tries to characterize volcanic rocks through the development and application of an empirical geomechanical system. Geotechnical information was collected from the samples from several Atlantic Ocean islands including Madeira, Azores and ...
T. Miranda, L.R. Sousa, A.T. Gomes, J. Tinoco, C. Ferreira   +4 more
doaj   +1 more source

Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis

Advanced Science, EarlyView.
This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu, Yaqian Cui, Yongqiang Zhou, Yihui Zheng, Lijiang Huang, Leiming Jin, Qianhui Zhang, Pan Chen, Mengsha Lin, Jiaxi Ye, Yongqiang Xiong, Joo Young Huh, Xiang Hu, Xiaokun Li, Wu Luo, Guang Liang   +15 more
wiley   +1 more source

FASLG Derived from Fibroblasts in Hydroxyapatite‐Rich Microenvironment Induces Urothelial Anoikis to Trigger Randall's Plaque Exposure

Advanced Science, EarlyView.
Randall's plaques (RP) serve as the nidus for calcium oxalate (CaOx) kidney stones. The current study reveals that hydroxyapatite (HAP) crystals activate the THY1–GSK3α/β–β‐catenin axis in renal interstitial fibroblasts (hRIFs), inducing FASLG secretion.
Minghui Liu, Maolan Wu, Meng Gao, Yongchao Li, Miao Yuan, Zhangcheng Liao, Zhi Liu, Yizhou Wang, Yu Cui, Jinbo Chen, Cheng He, Zhiyong Chen, Feng Zeng, Hequn Chen, Zewu Zhu   +14 more
wiley   +1 more source

Prediction of rock mass classification in tunnel boring machine tunneling using the principal component analysis (PCA)–gated recurrent unit (GRU) neural network

Deep Underground Science and Engineering
Due to the complexity of underground engineering geology, the tunnel boring machine (TBM) usually shows poor adaptability to the surrounding rock mass, leading to machine jamming and geological hazards.
Ke Man, Liwen Wu, Xiaoli Liu, Zhifei Song, Kena Li, Nawnit Kumar   +5 more
doaj   +1 more source

NUMERICAL SIMULATION OF JOINTED ROCK MASS IN GEOMECHANICAL PROBLEMS [PDF]

, 2018
Study the possibility of realistically numerical simulation of a jointed rock mass and estimate the design rock mass strength involving discontinuity surface conditions and various shapes and sizes of rock ...
BABETS, Dmytro, SOSNA, Dmytro, Бабец, Д. В., Бабец, Дмитрий Владимирович, Бабець, Д. В., Бабець, Дмитро Володимирович, С, Сосна, Д. О., Сосна, Дмитрий Олегович, Сосна, Дмитро Олегович   +9 more
core  

Large‐Scale Genomics Reveals Three‐Source Ancestry and Layered Adaptation to High Altitude in Tibetan Chickens

Advanced Science, EarlyView.
Whole‐genome analysis of 1,054 chickens reveals three ancestral sources (NWC, SYA, and SHF) with distinct temporal entry patterns into the Tibetan Plateau. Route‐specific selection scans, calibrated against a demographic null, suggest complementary functional enrichments—vascular homeostasis (NWC), calcium signaling and cardiac adaptation (SYA), and ...
Zongyi Zhao, Ruixue Nie, Hailu Fan, Tenzin Ngodroup, Li Zhu, Hongbin Pan, Bo Zhang, Hao Zhang   +7 more
wiley   +1 more source

Applicability of geomechanical classifications for estimation of strength properties in Brazilian rock masses

Anais da Academia Brasileira de Ciências
Many authors have been proposed several correlation equations between geomechanical classifications and strength parameters. However, these correlation equations have been based in rock masses with different characteristics when compared to Brazilian ...
TATIANA B. SANTOS, MILENE S. LANA, ALLAN E.M. SANTOS, LARISSA R.C. SILVEIRA   +3 more
doaj   +1 more source

Swamp dredge: Research into grunge [PDF]

, 2010
For this project I have researched grunge music and created a body of work influenced by this genre. During my extended contextual research into the genre, I looked at both the artists and producers.
Thompson, Lora
core   +1 more source

Bioinspired Adaptive Leg‐Claw Enables Robust Perching and Grasping for UAVs

Advanced Science, EarlyView.
Inspired by owl limb morphology and bat roosting behavior, this study presents a bioinspired adaptive leg‐claw mechanism that enables UAVs to perform robust and versatile perching and grasping. The design integrates a four‐link tibial structure, tension‐driven deformable feet, and active control, enabling stable perching on various branches and ...
Tianyu Cheng, Shaokun Wang, Jiehan Zou, Guiwen Shi, Zhongxue Gan, I‐Ming Chen, Guo‐Niu Zhu   +6 more
wiley   +1 more source

A Soft Matrix Microenvironment Promotes Laterally Spreading Tumors via Oxidative Phosphorylation‐Dependent Cell Adhesion

Advanced Science, EarlyView.
Laterally spreading tumors (LSTs) are precancerous colorectal lesions characterized by a flat morphology. This study reveals a mechanochemical pathway through which a soft matrix microenvironment diminishes spatial constraints in intestinal adenomas. This process promotes deficiencies in tight junction proteins, mediated by the mechanoreceptor ADORA2B ...
Jiamin Zhong, Jingyi Lu, Haopeng Li, Jun Zhong, Xiaobei Luo, Yiyi Hu, Xianfei Wang, Pengfei Wang, Yanning Zhang, Zhenjiang Wang, Qiuhua Lai, Zhenyu Chen, Wenting Mi, Wang Tin San‐to, Weize Li, Shuping Tan, Qihong Cheng, Ruijia Li, Yida Nie, Side Liu, Bing Huang, Zelong Han   +21 more
wiley   +1 more source