Results 31 to 40 of about 21,729 (297)
Comparative Assessment of Two Rocking Isolation Techniques for a Motorway Overpass Bridge
Frontiers in Built Environment, 2017 Rocking isolation of structures is evolving as an alternative design concept in earthquake engineering. The present paper investigates the seismic performance of an actual overpass bridge of the Attiki Odos motorway (Athens, Greece), employing two ...
Athanasios Agalianos +4 more
doaj +1 more source
Seismic Overturning of Rocking Structures with External Viscous Dampers
, 2013 Numerous structures exhibit rocking behavior during earthquakes and there is a continuing need to retrofit these structures to prevent collapse. The behavior of stand-alone rocking structures has been thoroughly investigated, but there are relatively few
DeJong, Matthew J. +3 more
core +2 more sources
Preliminary considerations on the rocking behavior of foundations in precast industrial buildings [PDF]
, 2023 Recent research has shown the importance of considering the soil-structure interaction in evaluating the seismic response of structures. In the specific case of precast buildings, with not-interconnected footing foundations, it is important to evaluate ...
Giretti, Daniela +2 more
core +1 more source
Applied SciencesRocking walls can control the overall deformation pattern and the distribution of plastic energy dissipation in structures, suppressing the occurrence of weak layers.
Youfa Yang, Yingwei Jia, Hongshen Jin
doaj +1 more source
Shock and Vibration, 2020 Elevated water tanks are categorized as strategic components of water supply systems in modern urban management. Past earthquake events have revealed the high vulnerability of these structures. This paper investigates the development of rocking isolation
Hassan Alemzadeh +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
A Simplified Mechanical Model for Rocking Structures on Compliant Foundations
Applied MechanicsHousner’s classical rocking model assumes a rigid base, which often leads to inaccurate seismic assessments under real–world soil conditions. This study quantitatively establishes the applicability limits of the rigid–base assumption and defines a ...
Baojun Yuan +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source