Results 31 to 40 of about 900,993 (312)
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
The Study of Geomechanical Condition of Unstable Rocks in the Vicinity of Mine Working Junctions
Горные науки и технологии, 2019 The relevance of research of material strain nature based on physical models equivalent to rocks is substantiated. To identify the dependencies and mechanism of unstable rock strain in the vicinity of mine working junctions, an experimental technique has
V. V. Basov
doaj +1 more source
RUDN Journal of Engineering Research, 2022 The work is devoted to the problem of increasing the reliability of the calculation of the permeability cube in the construction of a threedimensional geological model.
Pavel N. Strakhov +1 more
doaj +1 more source
Polyhedral colloidal `rocks': low-dimensional networks
, 2011 We introduce a model system of anisotropic colloidal `rocks'. Due to their shape, the bonding introduced via non-absorbing polymers is profoundly different from spherical particles: bonds between rocks are rigid against rotation, leading to strong ...
Bianchi +25 more
core +1 more source
Niemcza diorites and moznodiorites (Sudetes, SW Poland): a record of changing geotectonic setting at ca. 340 Ma [PDF]
, 2013 Granites sensu lato in the Sudetes intruded in several episodes during the Variscan orogeny recording different stages of crust and mantle evolution.
Kierczak, Jakub +2 more
core +1 more source
YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
Molecular Oncology, EarlyView.The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy +9 more
wiley +1 more source
Modelling Spectral Unmixing of Geological Mixtures: An Experimental Study Using Rock Samples
Remote Sensing, 2023 Spectral unmixing of geological mixtures, such as rocks, is a challenging inversion problem because of nonlinear interactions of light with the intimately mixed minerals at a microscopic scale. The fine-scale mixing of minerals in rocks limits the sensor’
Maitreya Mohan Sahoo +4 more
doaj +1 more source
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
Energies, 2021 This paper represents the results of experimental studies of physical modeling of the underground coal gasification process in terms of implementation of design and technological solutions aimed at intensification of a gasification process of thin coal ...
Oleg Bazaluk +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source