Results 181 to 190 of about 425,278 (248)

A Serum‐Stable Antimicrobial Peptide‐Based Delivery Platform for Selective Treatment of Nontargetable and Chemoresistant Tumors

Advanced Science, EarlyView.
A modular antimicrobial‐peptide‐based therapeutic system integrating membrane‐targeted selectivity, a conformation‐driven polyethylene glycolylated blocker, and serum‐stabilizing N‐cap is developed. The optimized conjugate 270 shows potent, rapid killing of the desired tumor cells, high serum stability, low off‐target toxicity, and broad applicability,
Tianxing Liu, Lingyu Ke, Ruize Sun, Xiaoling Chen, Mei Zhou, Olaf R. P. Bininda‐Emond, Chengbang Ma, Yangyang Jiang, Tao Wang, Chris Shaw, Lei Wang, Tianbao Chen, Alideertu Dong   +12 more
wiley   +1 more source

Cryptosporidium spp. in wild rodents in the Poyang Lake region, China. [PDF]

Parasite
Zuo Q, Weng X, Wang X, Liu H, Di M, Zhang X, Zhou B, Xue C, Lu P, Peng X, Shen Y, Cao J.   +11 more
europepmc   +1 more source

In silico prediction of the developmental toxicity of diverse organic chemicals in rodents for regulatory purposes [PDF]

, 2016
Nikita Basant, Shikha Gupta, Kunwar P. Singh   +2 more
openalex   +1 more source

Norepinephrine Induces Sertoli Cell Ferroptosis via Receptors Desensitization Causing Stress‐Related Male Reproductive Dysfunction

Advanced Science, EarlyView.
Psychological stress activates the sympathetic–adrenal axis, elevating norepinephrine (NE) and suppressing reproductive hormones, thereby impairing male reproduction. Excess NE overactivates and desensitizes β‐adrenergic receptors (β‐ARs), triggering Sertoli cell ferroptosis and disrupting spermatogenesis.
Lingyu Zhang, Shanfeng Gao, Xiaofan Xiong, Xin Liu, Rufeng Li, Xia Wang, Lin Han, Xuan Xiao, Xiaofei Wang, Wen Li, Yongxia Chang, Yuefeng Du, Juan Yang   +12 more
wiley   +1 more source

Looking at Both Sides: Integrating Data From Both Hemispheres Is Crucial in Rodent Neuroscience. [PDF]

Eur J Neurosci
Mundorf A, Ocklenburg S.
europepmc   +1 more source

Restoring Histone Acetylation Accelerates Diabetic Wound Repair by Improving the Spatiotemporal Dynamics of Macrophages

Advanced Science, EarlyView.
Butyrate—via epigenetic modulation of the histone core—rebalance dysregulated macrophage function and promotes wound healing under persisting hostile conditions of diabetic mice. Additionally, butyrate harmonizes macrophage interactions with keratinocytes and fibroblasts as well as breaks the vicious cycle of inflammation in chronic wounds by restoring
Karmveer Singh, Albert Kallon Koroma, Rajeev Kumar Pandey, Yongfang Wang, Jinnan Cheng, Philipp Haas, Mahyar Aghapour, Linda Krug, Adelheid Hainzl, Meinhard Wlaschek, Pallab Maity, Karin Scharffetter‐Kochanek   +11 more
wiley   +1 more source

Marine resources alter tundra food web dynamics by subsidizing a terrestrial predator on the sea ice. [PDF]

Ecology
Johnson-Bice SM, Baldwin FB, Richardson ES, Roth JD.   +3 more
europepmc   +1 more source

Tie2‐Dependent Mechanisms Influence Leptomeningeal Collateral Dynamics and Reperfusion Following Stroke

Advanced Science, EarlyView.
This work demonstrates that endothelial EphA4 limits Tie2 activation and curbs leptomeningeal collateral expansion after ischemic stroke. Pharmacological activation of Tie2 by an Ang‐1 mimetic or genetic loss of EphA4 stimulates collateral vessel growth, improves cerebral perfusion, and enhances neurological recovery.
Alexandra M. Kaloss, Caroline de Jager, Kennedie Lyles, Nathalie A. Groot, Jackie Zhu, Yu Lin, Michael Chen, Hehuang Xie, John B. Matson, Michelle H. Theus   +9 more
wiley   +1 more source

Socioeconomic and environmental predictors of lassa fever transmission in Lower Bambara Chiefdom, Kenema District, Eastern Sierra Leone. [PDF]

BMC Public Health
Kamara AS, Moseray A, Fatoma P, Lamin JM, Sankoh OA, Rogers MK.   +5 more
europepmc   +1 more source

Vitamin A modulation of xenobiotic-induced hepatotoxicity in rodents.

, 1994
Stephen B. Hooser, Rhonda J. Rosengren, David Hill, Scott Alven. Mobley, I.G. Sipes   +4 more
openalex   +2 more sources