Results 61 to 70 of about 942,431 (379)

Molecular mechanisms of melatonin in mitigating compound salt stress in Sophora alopecuroides revealed by physiological and transcriptomic profiling

open access: yesPlant Stress
Melatonin is a conserved multifunctional signaling molecule in plants, which regulates many developmental processes and responds to stress. Although many studies have involved melatonin in plants, it is not clear whether the application of exogenous ...
Youwei Zhang   +5 more
doaj   +1 more source

Rodent models in neuroscience research: is it a rat race?

open access: yesDisease Models & Mechanisms, 2016
Rodents (especially Mus musculus and Rattus norvegicus) have been the most widely used models in biomedical research for many years. A notable shift has taken place over the last two decades, with mice taking a more and more prominent role in biomedical ...
B. Ellenbroek, J. Youn
semanticscholar   +1 more source

Rats: an ecologically-based approach for managing a global problem [PDF]

open access: yes, 2007
Many people have problems with pest rodents. Rats eat our crops, contaminate our stored food, damage our buildings and possessions and spread dangerous diseases to people and livestock.
Belmain, Steven
core  

Effect of environmental factors on the abundance variations of two native rodents in agricultural systems of Buenos Aires, Argentina [PDF]

open access: yes, 2019
Our aim was to assess the effect of environmental factors on short temporal abundance variations of the two most abundant native rodents of agricultural agroecosystems, Akodon azarae and Calomys laucha.
Busch, Maria   +3 more
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Morphometric dataset of Varanus salvator for non-invasive sex identification using machine learning

open access: yesScientific Data
Reliable sex identification in Varanus salvator traditionally relied on invasive methods like genetic analysis or dissection, as less invasive techniques such as hemipenes inversion are unreliable.
Ariff Azlan Alymann   +5 more
doaj   +1 more source

Cisplatin-Induced Rodent Model of Kidney Injury: Characteristics and Challenges

open access: yesBioMed Research International, 2018
Cisplatin is an antitumor drug used in the treatment of a wide variety of malignancies. However, its primary dose-limiting side effect is kidney injury, which is a major clinical concern.
M. Perše, Ž. Večerić-Haler
semanticscholar   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

open access: yesMolecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute   +17 more
wiley   +1 more source

Rodent models of AKI-CKD transition.

open access: yesAJP - Renal Physiology, 2018
Acute kidney injury (AKI) is a contributing factor in the development and progression of chronic kidney disease (CKD). Despite rapid progresses, the mechanism underlying AKI-CKD transition remains largely unclear.
Ying Fu   +5 more
semanticscholar   +1 more source

Agriculture and forest rodent problems and control in Italy [PDF]

open access: yes, 1986
Rodent pest problems and their control in Italy are reviewed. Two rats, Rattus norvegicus and Rattus rattus, and the field mouse, Apodemus sylvaticus, are often important pests both in rural and forestry areas.
Santini, Luciano A.
core  

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