Results 71 to 80 of about 942,431 (379)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Ecological responses of Orientallactaga sibirica: Variations in body size and trophic niche across changing habitats

Global Ecology and Conservation
In arid ecosystems, precipitation and temperature are two key factors, with altitude further shaping habitat conditions through its regulatory effects on temperature.
Qi-qige Buren, Xin Li, Guo-kang Chen, Guo-hui Ye, Shan-shan Sun, Yong-ling Jin, Ming-ming, He-Ping Fu, Shuai Yuan   +8 more
doaj   +1 more source

Rodent Models of Nonalcoholic Fatty Liver Disease

Digestion, 2019
Background: Nonalcoholic fatty liver disease (NAFLD) is a continuous diseases spectrum associated with obesity, type 2 diabetes, insulin resistance, and hyperlipidemia.
F. Zhong, Xiaoming Zhou, Jin Xu, Ling Gao   +3 more
semanticscholar   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer's disease in rodent models

Nature Communications, 2016
Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase-1 (COX-1) and COX-2 enzymes. The NLRP3 inflammasome is a multi-protein complex responsible for the processing of the proinflammatory cytokine interleukin-1β and is implicated in many ...
Michael J. D. Daniels, J. Rivers-Auty, T. Schilling, Nicholas G. Spencer, William Watremez, Victoria Fasolino, S. J. Booth, Claire S. White, A. Baldwin, S. Freeman, Raymond Wong, Clare H Latta, Shi Yu, Joshua Jackson, N. Fischer, V. Koziel, T. Pillot, J. Bagnall, S. Allan, P. Paszek, J. Galea, M. Harte, C. Eder, C. Lawrence, D. Brough   +24 more
semanticscholar   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Host selection and influencing factors of parasitic fleas on the body surface of desert rodents, Inner Mongolia, China

International Journal for Parasitology: Parasites and Wildlife
Fleas frequently parasitize rodents and serve as major vectors for many zoonotic diseases. The Alxa Desert in Inner Mongolia, China, is a typical arid region in Asia, which is suitable for the coexistence of a variety of rodents in this environment ...
Haiwen Yan, Fan Bu, Xinyu Wu, Haoting Zhang, Shanshan Sun, Wenke Bai, Xiaodong Wu, Shuai Yuan, Heping Fu   +8 more
doaj   +1 more source

Spatio-temporal home range of the dominant rodent species in Mabira central forest reserve, Uganda

BMC Ecology and Evolution, 2023
Background Rodents form the largest order among mammals in terms of species diversity, and home range is the area where an individual normally moves during its normal daily activities.
James Ssuuna, Rhodes H. Makundi, Simon J. Chidodo, Moses Isabirye, Nsajigwa E. Mbije, Loth S. Mulungu   +5 more
doaj   +1 more source

How to Translate Time? The Temporal Aspect of Human and Rodent Biology

Frontiers in Neurology, 2017
Therapeutic interventions can only be effective when administered during their specific " therapeutic window. " A multitude of clinical trials based on highly successful preclinical studies performed mostly in rodents have failed to translate into ...
D. Agoston
semanticscholar   +1 more source

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source