Results 91 to 100 of about 10,821,016 (340)

1st INCF Workshop on Genetic Animal Models for Brain Diseases [PDF]

, 2011
The INCF Secretariat organized a workshop to focus on the “role of neuroinformatics in the processes of building, evaluating, and using genetic animal models for brain diseases” in Stockholm, December 13–14, 2009.
Holm Graessner, Olaf Riess
core   +2 more sources

Associations of Sleep and Shift Work With Osteoarthritis Risk

Arthritis Care &Research, EarlyView.
Objective Daily rhythms may be critical for maintaining homeostasis of joint tissues. We aimed to investigate the relationships among circadian clock disruption, sleep, and osteoarthritis (OA) risk in humans. Methods In the UK Biobank, a prospective 500,000–person cohort, we evaluated associations among sleep duration, sleeplessness/insomnia, and shift
Elizabeth L. Yanik, Abigail Bridgeman, Erik D. Herzog, Vy Pham, Bradley A. Evanoff, Farshid Guilak   +5 more
wiley   +1 more source

Modeling the effects of variable feeding patterns of larval ticks on the transmission of Borrelia lusitaniae and Borrelia afzelii [PDF]

, 2017
Spirochetes belonging to the Borrelia burgdoferi sensu lato (sl) group cause Lyme Borreliosis (LB), which is the most commonly reported vector-borne zoonosis in Europe. B. burgdorferi sl is maintained in nature in a complex cycle involving Ixodes ricinus
Bertolotti, Luigi, Ferreri, Luca, Giacobini, Mario, Mannelli, Alessandro, Perazzo, Silvia, Venturino, Ezio   +5 more
core   +2 more sources

Poly(lactic‐co‐glycolic acid) Nanoparticles for IL‐12 Self‐Amplifying RNA Delivery in Glioblastoma Models

Advanced Functional Materials, EarlyView.
xxxx. ABSTRACT Glioblastoma (GBM) remains one of the most lethal brain cancers, with median survival rarely exceeding 15 months after diagnosis. Interleukin‐12 (IL‐12) is a potent immunostimulatory cytokine capable of reshaping the tumor microenvironment (TME), yet its clinical translation is hindered by systemic toxicity and short half‐life. RNA‐based
Fatima Hameedat, Johan Sebastian Lopez‐Parra, Willem M. H. Hoogaars, Emma Dijkstra, Cynthia Huang, Irafasha C. Casmil, Anna K. Blakney, Peter Olinga, Barbara Rothen‐Rutishauser, Hélder A. Santos, Alke Petri‐Fink, Flávia Sousa   +11 more
wiley   +1 more source

DNA Checkpoint and Repair Factors Are Nuclear Sensors for Intracellular Organelle Stresses-Inflammations and Cancers Can Have High Genomic Risks. [PDF]

, 2018
Under inflammatory conditions, inflammatory cells release reactive oxygen species (ROS) and reactive nitrogen species (RNS) which cause DNA damage. If not appropriately repaired, DNA damage leads to gene mutations and genomic instability.
Chen, Hongping, Choi, Eric T., Cueto, Ramon, Drosatos, Konstantinos, Fu, Hangfei, Nanayakkara, Gayani K, Park, Joon Y., Qin, Xuebin, Shao, Lijian, Shao, Ying, Sheng, Haitao, Sun, Jianxin, Sun, Yu, Wang, Hong, Wang, Luqiao, Wu, Na, Yang, Qian, Yang, William Y, Yang, Wuping, Yang, Xiaofeng, Zeng, Huihong, Zhu, Qingxian   +21 more
core   +2 more sources

Lessons from rodent models in celiac disease [PDF]

Mucosal Immunology, 2015
Over the past 25 years, studies led in humans have considerably improved our understanding of celiac disease, a complex disease that is generally defined as an autoimmune-like enteropathy induced by dietary gluten in genetically predisposed individuals.
N, Korneychuk, B, Meresse, N, Cerf-Bensussan   +2 more
openaire   +2 more sources

Synergistic All‐in‐One Electroceutical Platform Utilizing a Plasma–Photodynamic Hybrid Approach for Enhanced Wound Healing

Advanced Functional Materials, EarlyView.
A flexible hybrid patch integrating a robust cold atmospheric plasma (CAP) system with a high‐power, ultrathin bio‐OLED was developed to enable synergistic wound healing. This multimodal therapy, combining plasma and photodynamic treatment, enhanced angiogenesis, cell proliferation, and collagen deposition, demonstrating superior in vivo efficacy and ...
Jun‐Yeop Song, Hyun Cheol Bang, Young Hyun Son, Dae‐In Ha, Eun‐Ju Hong, Sun‐Woo Lee, Jeongsook Kim, Doyeong Kim, Sang‐Min Park, Kyu Pil Lee, Hyo‐Jung Kwon, Jeong Hyun Kwon   +11 more
wiley   +1 more source

Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer's disease in rodent models

Nature Communications, 2016
Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase-1 (COX-1) and COX-2 enzymes. The NLRP3 inflammasome is a multi-protein complex responsible for the processing of the proinflammatory cytokine interleukin-1β and is implicated in many ...
Michael J. D. Daniels, J. Rivers-Auty, T. Schilling, Nicholas G. Spencer, William Watremez, Victoria Fasolino, Sophie Booth, Claire S. White, A. Baldwin, S. Freeman, Raymond Wong, Clare H Latta, Shi Yu, Joshua Jackson, N. Fischer, V. Koziel, T. Pillot, J. Bagnall, S. Allan, P. Paszek, J. Galea, M. Harte, C. Eder, C. Lawrence, D. Brough   +24 more
semanticscholar   +1 more source

Translational Considerations for Injectable Biomaterials and Bioscaffolds to Repair and Regenerate Brain Tissue

Advanced Healthcare Materials, EarlyView.
The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley   +1 more source

Fourteen-year status report of fatal illnesses in captive chinchilla (Chinchilla lanigera) [PDF]

, 2016
Fur ranching has been a prosperous industry for decades. Despite its worldwide distribution, little published information is available regarding the importance of the various causes of death in chinchilla (Chinchilla lanigera).
Bautista, Emilia Lucila, Gimeno, Eduardo Juan, Martino, Pablo Eduardo, Radman, Nilda Esther, Stanchi, Nestor Oscar   +4 more
core   +3 more sources