Results 71 to 80 of about 341,043 (301)

Mapping global risk of bat and rodent borne disease outbreaks to anticipate emerging threats

Scientific Reports
Future epidemics and/or pandemics may likely arise from zoonotic viruses with bat- and rodent-borne pathogens being among the prime candidates. To improve preparedness and prevention strategies, we predicted the global distribution of bat- and rodent ...
Soushieta Jagadesh, Claudia Cataldo, Wim Van Bortel, Esther Van Kleef, William Wint, Annapaola Rizzoli, Luca Busani, Elena Arsevska   +7 more
doaj   +1 more source

Animal Models of Metabolic Disorders in the Study of Neurodegenerative Diseases: An Overview

Frontiers in Neuroscience, 2021
The incidence of metabolic disorders, as well as of neurodegenerative diseases—mainly the sporadic forms of Alzheimer’s and Parkinson’s disease—are increasing worldwide.
Andreza Fabro de Bem, Rachel Krolow, Hémelin Resende Farias, Victória Linden de Rezende, Daniel Pens Gelain, José Cláudio Fonseca Moreira, João Miguel das Neves Duarte, João Miguel das Neves Duarte, Jade de Oliveira   +8 more
doaj   +1 more source

Rodent genetic models of Huntington disease

Neurobiology of Disease, 2008
Huntington disease (HD) is a dominantly inherited human neurodegenerative disorder characterized by motor deficits, cognitive impairment, and psychiatric symptoms leading to inexorable decline and death. Since the identification of the huntingtin gene and the characteristic expanded CAG repeat/polyglutamine mutation, multiple murine genetic models and ...
Mary Y. Heng, Peter J. Detloff, Roger L. Albin   +2 more
openaire   +3 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Knowledge, risk perceptions and practices regarding rodents and their associated pathogens: environmental consultants in Chile

One Health Outlook
Background Rodents play essential ecological roles but are also significant reservoirs of zoonotic pathogens, posing risks to humans. Individuals with frequent occupational contact with rodents face an elevated risk of exposure to rodent-borne diseases ...
Esteban Vásquez, Rodrigo Salgado, Hugo Mendoza, Diego A. Peñaranda, Darío Moreira-Arce, André V. Rubio   +5 more
doaj   +1 more source

Use of large animal models to investigate Huntington's diseases

Cell Regeneration, 2019
Animal models that can mimic human diseases are the important tools for investigating the pathogenesis of the diseases and finding a way for treatment.
Sen Yan, Shihua Li, Xiao-Jiang Li
doaj   +1 more source

Metagenomic analysis of viromes in tissues of wild Qinghai vole from the eastern Tibetan Plateau

Scientific Reports, 2022
Rodents are natural reservoirs of diverse zoonotic viruses and widely distributed on the Tibetan Plateau. A comprehensive understanding of the virome in local rodent species could provide baseline of viral content and assist in efforts to reduce the risk
Xiaozhou He, Xu Wang, Guohao Fan, Fan Li, Weiping Wu, Zhenghuan Wang, Meihua Fu, Xu Wei, Shuo Ma, Xuejun Ma   +9 more
doaj   +1 more source

Neuroprotective effects of carnitinoid compounds in rodent cellular and in vivo models of mitochondrial complex I dysfunction [PDF]

, 2019
Rotenone-mediated mitochondrial complex I inhibition was used to model Parkinson’s disease-like syndrome in Lewis rats. Tyrosine hydroxylase immunolabeling demonstrated a decrease in the number of dopaminergic neurons as well as aberrant morphology in ...
Steliou, Kosta
core  

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017. [PDF]

, 2017
This is a report on the CNS barrier congress held in London, UK, March 22-23rd 2017 and sponsored by Kisaco Research Ltd. The two 1-day sessions were chaired by John Greenwood and Margareta Hammarlund-Udenaes, respectively, and each session ended with a ...
A Brenn, A Reijerkerk, B Zhang, C Cerutti, DA Ridder, EJ Duh, ES Lippmann, GK Dogbevia, HC Helms, HC Helms, I Loryan, I Loryan, J Greenwood, J Keaney, J Korbelin, JA Ford, M Brkic, M Campbell, M Campbell, MA Lopez-Ramirez, O Huber, P Canning, R Martinelli, RE Vandenbroucke, S Balusu, S Dragoni, Y Hu, Y Molino, YH Chen   +28 more
core   +9 more sources