Results 51 to 60 of about 210,135 (261)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Are rodent models of Parkinson’s disease behaving as they should? [PDF]

Behavioural Brain Research, 2018
In recent years our understanding of Parkinson's disease has expanded both in terms of pathological hallmarks as well as relevant genetic influences. In parallel with the aetiological discoveries a multitude of PD animal models have been established. The vast majority of these are rodent models based on environmental, genetic and mechanistic insight. A
Vingill, Siv, Connor-Robson, Natalie, Wade-Martins, Richard   +2 more
openaire   +3 more sources

PIODERMITE PROFUNDA POR Corynebacterium pseudotuberculosis EM CUTIA (Dasyprocta sp.)

Ciência Animal Brasileira, 2010
Bacterial skin diseases represent a significant ratio ofrodents’ pathologies. However, in agoutis (Dasyprocta sp.), amiddle-sized rodent with geographic distribution from Central toSouth America, reports on isolated bacterial agents of ...
Kilder Dantas Filgueira, Moacir Franco de Oliveira, Jael Soares Batista, Francisco Marlon Carneiro Feijó, Valéria Veras de Paula   +4 more
doaj  

Mapping global risk of bat and rodent borne disease outbreaks to anticipate emerging threats

Scientific Reports
Future epidemics and/or pandemics may likely arise from zoonotic viruses with bat- and rodent-borne pathogens being among the prime candidates. To improve preparedness and prevention strategies, we predicted the global distribution of bat- and rodent ...
Soushieta Jagadesh, Claudia Cataldo, Wim Van Bortel, Esther Van Kleef, William Wint, Annapaola Rizzoli, Luca Busani, Elena Arsevska   +7 more
doaj   +1 more source

A Remote Monitoring System for Rodent Infestation Based on LoRaWAN

Sensors, 2023
Rodent infestations are a common problem that can result in several issues, including diseases, damage to property, and crop loss. Conventional methods of controlling rodent infestations often involve using mousetraps and applying rodenticides manually ...
Shin-Chi Lai, Szu-Ting Wang, Kuan-Lin Liu, Chang-Yu Wu   +3 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Knowledge, risk perceptions and practices regarding rodents and their associated pathogens: environmental consultants in Chile

One Health Outlook
Background Rodents play essential ecological roles but are also significant reservoirs of zoonotic pathogens, posing risks to humans. Individuals with frequent occupational contact with rodents face an elevated risk of exposure to rodent-borne diseases ...
Esteban Vásquez, Rodrigo Salgado, Hugo Mendoza, Diego A. Peñaranda, Darío Moreira-Arce, André V. Rubio   +5 more
doaj   +1 more source

Animal Models of Metabolic Disorders in the Study of Neurodegenerative Diseases: An Overview

Frontiers in Neuroscience, 2021
The incidence of metabolic disorders, as well as of neurodegenerative diseases—mainly the sporadic forms of Alzheimer’s and Parkinson’s disease—are increasing worldwide.
Andreza Fabro de Bem, Rachel Krolow, Hémelin Resende Farias, Victória Linden de Rezende, Daniel Pens Gelain, José Cláudio Fonseca Moreira, João Miguel das Neves Duarte, João Miguel das Neves Duarte, Jade de Oliveira   +8 more
doaj   +1 more source

Rodent genetic models of Huntington disease

Neurobiology of Disease, 2008
Huntington disease (HD) is a dominantly inherited human neurodegenerative disorder characterized by motor deficits, cognitive impairment, and psychiatric symptoms leading to inexorable decline and death. Since the identification of the huntingtin gene and the characteristic expanded CAG repeat/polyglutamine mutation, multiple murine genetic models and ...
Mary Y. Heng, Peter J. Detloff, Roger L. Albin   +2 more
openaire   +3 more sources