Results 51 to 60 of about 215,717 (294)

Are rodent models of Parkinson’s disease behaving as they should? [PDF]

Behavioural Brain Research, 2018
In recent years our understanding of Parkinson's disease has expanded both in terms of pathological hallmarks as well as relevant genetic influences. In parallel with the aetiological discoveries a multitude of PD animal models have been established. The vast majority of these are rodent models based on environmental, genetic and mechanistic insight. A
Vingill, Siv, Connor-Robson, Natalie, Wade-Martins, Richard   +2 more
openaire   +3 more sources

Land-use change and rodent-borne diseases: hazards on the shared socioeconomic pathways [PDF]

, 2021
Land-use change has a direct impact on species survival and reproduction, altering their spatio-temporal distributions. It acts as a selective force that favours the abundance and diversity of reservoir hosts and affects host–pathogen dynamics and ...
Aguirre, A. Alonso, Suzán, Gerardo, García Peña, Gabriel E., Fernández, Miguel, Zambrana Torrelio, Carlos, Mendoza, Hugo, Milholland, Matthew T., Rubio Carrasco, André Víctor   +7 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

PIODERMITE PROFUNDA POR Corynebacterium pseudotuberculosis EM CUTIA (Dasyprocta sp.)

Ciência Animal Brasileira, 2010
Bacterial skin diseases represent a significant ratio ofrodents’ pathologies. However, in agoutis (Dasyprocta sp.), amiddle-sized rodent with geographic distribution from Central toSouth America, reports on isolated bacterial agents of ...
Kilder Dantas Filgueira, Moacir Franco de Oliveira, Jael Soares Batista, Francisco Marlon Carneiro Feijó, Valéria Veras de Paula   +4 more
doaj  

Mapping global risk of bat and rodent borne disease outbreaks to anticipate emerging threats

Scientific Reports
Future epidemics and/or pandemics may likely arise from zoonotic viruses with bat- and rodent-borne pathogens being among the prime candidates. To improve preparedness and prevention strategies, we predicted the global distribution of bat- and rodent ...
Soushieta Jagadesh, Claudia Cataldo, Wim Van Bortel, Esther Van Kleef, William Wint, Annapaola Rizzoli, Luca Busani, Elena Arsevska   +7 more
doaj   +1 more source

Animal Models of Metabolic Disorders in the Study of Neurodegenerative Diseases: An Overview

Frontiers in Neuroscience, 2021
The incidence of metabolic disorders, as well as of neurodegenerative diseases—mainly the sporadic forms of Alzheimer’s and Parkinson’s disease—are increasing worldwide.
Andreza Fabro de Bem, Rachel Krolow, Hémelin Resende Farias, Victória Linden de Rezende, Daniel Pens Gelain, José Cláudio Fonseca Moreira, João Miguel das Neves Duarte, João Miguel das Neves Duarte, Jade de Oliveira   +8 more
doaj   +1 more source

Rodent genetic models of Huntington disease

Neurobiology of Disease, 2008
Huntington disease (HD) is a dominantly inherited human neurodegenerative disorder characterized by motor deficits, cognitive impairment, and psychiatric symptoms leading to inexorable decline and death. Since the identification of the huntingtin gene and the characteristic expanded CAG repeat/polyglutamine mutation, multiple murine genetic models and ...
Mary Y. Heng, Peter J. Detloff, Roger L. Albin   +2 more
openaire   +3 more sources

Rodent-borne zoonoses in Qatar: A possible One-Health framework for the intervention of future epidemic

, 2023
The increasing frequency of spillover of zoonotic pathogens from animals to humans in recent years highlights a need to develop a more comprehensive framework to investigate and prevent pathogens of animal origin, including rodents.
Abdulla M. Al-Marri (17871023), Mohammad Mahmudul Hassan, Zilungile L. Mkhize-Kwitshana (17871032), Mohammad Mahmudul Hassan (11320450), Muzzamil Atta, Abdulla M. Al-Marri, Md. Mazharul Islam (9082853), Devendra Bansal, Syed Shariq Jaffrey (17871017), Hamad Al Romaihi (17871029), Elmoubashar Farag, Hamad Al Romaihi, Elmoubashar Farag (14834653), Abdulaziz M. Al-Zeyara (17871026), Md. Mazharul Islam, Zilungile L. Mkhize-Kwitshana, Syed Shariq Jaffrey, Muzzamil Atta (17871020), Devendra Bansal (255958), Abdulaziz M. Al-Zeyara   +19 more
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Knowledge, risk perceptions and practices regarding rodents and their associated pathogens: environmental consultants in Chile

One Health Outlook
Background Rodents play essential ecological roles but are also significant reservoirs of zoonotic pathogens, posing risks to humans. Individuals with frequent occupational contact with rodents face an elevated risk of exposure to rodent-borne diseases ...
Esteban Vásquez, Rodrigo Salgado, Hugo Mendoza, Diego A. Peñaranda, Darío Moreira-Arce, André V. Rubio   +5 more
doaj   +1 more source