Results 161 to 170 of about 209,868 (261)

Distribution of Big Tau Isoforms in the Human Central and Peripheral Nervous System

Annals of Neurology, EarlyView.
Objective Tau is widely studied in neurodegeneration, yet most work has focused on canonical brain tau isoforms. A longer isoform, “big tau,” produced by inclusion of exon 4a, is expressed in the peripheral nervous system (PNS) and central nervous system (CNS) regions.
Rama Krishna Koppisetti, Nicolas R. Barthélemy, Kanta Horie, Cindy V. Ly, Kaleigh F. Roberts, Srinivas Koutarapu, Richard J. Perrin, Erin E. Franklin, Chiara Pedicone, Joshua Orrick, Justin Melendez, Timothy M. Miller, Chihiro Sato, Nupur Ghoshal, Alison M. Goate, Celeste M. Karch, Randall J. Bateman, Soumya Mukherjee   +17 more
wiley   +1 more source

Identification and genetic characterization of a distinct genotype of Puumala orthohantavirus in Hebei Province, China. [PDF]

PLoS Negl Trop Dis
Cai Y, Wei Y, Du G, Zhang X, Wang Z, Wang Z, Han Z, Zhang Y, Xu Y, Han X, Li J, Li Q.   +11 more
europepmc   +1 more source

Maternal‐Fetal Administration of Risdiplam Partially Rescues the SMNΔ7 Mouse Model of Spinal Muscular Atrophy

Annals of Neurology, EarlyView.
Objective Spinal muscular atrophy (SMA) is caused by deletions or mutations in the survival motor neuron 1 (SMN1) gene and subsequent reduction in the expression of survival motor neuron (SMN) protein. The disease is characterized by degeneration of α motor neurons and subsequent muscle atrophy.
Emma R. Sutton, Ariane Beauvais, Rebecca Yaworski, Hugh J. McMillan, Rashmi Kothary   +4 more
wiley   +1 more source

Ecotourism and the Hidden Ecology of Infection: The Andes Virus Cruise Outbreak. [PDF]

Infect Dis Rep
Scorzolini L, D'Abramo A, Girardi E, Nicastri E.   +3 more
europepmc   +1 more source

Modeling Catheter‐Associated Bladder Mucosal Adhesion and Microtrauma Using a Human Urothelial Microtissue Model

Advanced NanoBiomed Research, EarlyView.
Intermittent catheter use can damage the urinary tract and predispose to infection. We deployed a complex human urothelial model to investigate. Catheter contact induced compressive and shear stress causing umbrella cell disruption, reduced barrier function, inflammation and increased cell adhesion to the catheter surface.
Nazila V. Jafari, Jennifer L. Rohn
wiley   +1 more source

Going wild: prioritizing experimental models of rodent-borne viruses to decode zoonotic spillover and pandemic risk. [PDF]

J Virol
Honce R, Botten J.
europepmc   +1 more source

Spatial Cell Death and Oxidative Stress Dynamics in Gas Plasma‐Treated Tumor Tissues

Advanced NanoBiomed Research, EarlyView.
Schematic representation of the four experimental models to study tissue penetration and oxidation. Four tissue models were used. Human pancreatic cancer cells were grown on the chorioallantois membrane of chicken embryos and gas plasma‐treated in ovo, murine colorectal tumor tissue was gas plasma‐exposed ex vivo, murine squamous cell carcinoma cells ...
Anke Schmidt, Shahrzad Rokhsary, Linus Hübner, Lea Miebach, Sander Bekeschus   +4 more
wiley   +1 more source

Molecular Characterization and Zoonotic Potential of <i>Cryptosporidium</i> spp. and <i>Enterocytozoon bieneusi</i> in Wild Rodents and Sympatric Livestock in Xinjiang, China. [PDF]

Transbound Emerg Dis
Li Y, Hu X, Li Z, Dong H, Yuan Z, Liu G, Wang X, Shi F, Cao J, Jiang Y, Wang S, Wang Y.   +11 more
europepmc   +1 more source

Encephalomyocarditis virus (EMCV): An overlooked threat to primates. [PDF]

PLoS Negl Trop Dis
Amona I, Kumakamba C, Labarrere C, Davoust B, Fenollar F, Mediannikov O.   +5 more
europepmc   +1 more source

Finite element analysis of feeding in red and gray squirrels (Sciurus vulgaris and Sciurus carolinensis)

The Anatomical Record, EarlyView.
Abstract Invasive gray squirrels (Sciurus carolinensis) have replaced the native red squirrel (Sciurus vulgaris) across much of Great Britain over the last century. Several factors have been proposed to underlie this replacement, but here we investigated the potential for dietary competition in which gray squirrels have better feeding performance than ...
Philip G. Cox, Peter J. Watson
wiley   +1 more source