Results 161 to 170 of about 9,520,639 (370)

Cryptic Splicing of GAP43 mRNA is a Novel Hallmark of TDP‐43‐Associated ALS and AD

Advanced Science, EarlyView.
TDP‐43 dysfunction disrupts RNA processing, inducing cryptic exon 4a1 inclusion in GAP43 and reducing its protein levels. This aberrant splicing impairs axonal regeneration and contributes to neurodegeneration in ALS and AD. RNA‐seq of patient brains reveals GAP43 downregulation and 4a1 upregulation, identifying cryptic exon 4a1 as a potential ...
Mingming Yang, Qi Wang, Dongkun Kang, Shijia Wang, Yanli Jiang, Jian‐Zhi Wang, Chen Ming, Rong Liu, Jianlan Gu, Xiaochuan Wang   +9 more
wiley   +1 more source

Review article: the stages of gastrointestinal carcinogenesis - application of rodent models to human disease [PDF]

, 2000
Henry C. Pitot, Hiroshi Hikita, Yvonne P. Dragan, Linda M. Sargent, Michael J. Haas   +4 more
openalex   +1 more source

Rodent Biology and Management; Abstracts of papers presented at the International Conference on Rodent Biology and Management, held at Beijing, China, 5-9 October 1998 [PDF]

Farm Management,
Anonymous, Hinds, Lyn A., Singleton, Grant R., Wang, Zu-Wang   +3 more
core   +1 more source

IncRNA‐ZFAS1, an Emerging Gate‐Keeper in DNA Damage‐Dependent Transcriptional Regulation

Advanced Science, EarlyView.
LncZFAS1 plays a crucial role during DNA damage response in mammalian cells. Loss of lncZFAS1 results in deficient DNA lesion removal and reduced cell viability. Mechanistically, lncZFAS1 modulates RNAPII phosphorylation and transcription and thereby promotes both GG‐NER and TC‐NER upon UV damage.
Jiena Liu, Qing Lu, Zixuan Fan, Jiahui Lin, Nan He, Xin Zhang, Zhaoya Han, Tingting Zhu, Zhenzhen Wu, Yingying Xu, Yuming Wang   +10 more
wiley   +1 more source

Quinolinic Acid Released from Polymeric Brain Implants Causes Behavioral and Neuroanatomical Alterations in a Rodent Model of Huntington's Disease [PDF]

, 2000
Kristi L. Haik, Deborah A. Shear, Ulrike Schröeder, Bernhard A. Sabel, Gary Dunbar   +4 more
openalex   +1 more source

Hypoglycemia Induces Diabetic Macrovascular Endothelial Dysfunction via Endothelial Cell PANoptosis, Macrophage Polarization, and VSMC Fibrosis

Advanced Science, EarlyView.
This study investigates hypoglycemia‐induced diabetic macrovascular endothelial dysfunction. It reveals that hypoglycemia triggers ZBP1‐dependent PANoptosis of endothelial cells, proinflammatory polarization of macrophages, and fibrosis of vascular smooth muscle cells (VSMCs) in diabetic mice.
Deyu Zuo, Yuce Peng, Guozhi Zhao, Zhesheng Cheng, Minghao Luo, Dingyi Lv, Shuting Chang, Na Li, Yanyao Huang, Xunjia Li, An He   +10 more
wiley   +1 more source

Selected Zoonotic Diseases in Rodents

Rodents, representing 43% of mammalian species, play a pivotal role in the transmission of zoonotic diseases, serving as reservoirs for pathogens including viruses, bacteria, fungi, protozoa, and helminths. Over 217 rodent species are reservoirs for 66 zoonotic diseases, such as salmonellosis, leptospirosis, toxoplasmosis, hantavirus, and Lassa fever ...
özalp, tahir, Cengiz, Halil Emre, ERDOĞAN, HASAN, erdoğan, songül, Ural, Kerem   +4 more
openaire   +2 more sources

Chronic Psychological Stress Induces Cardiomyocyte Hypertrophy Through Corticosterone‐Glucocorticoid Receptor‐LAMA5 Axis

Advanced Science, EarlyView.
In vivo experiments suggest that cardiomyocyte hypertrophy is an early manifestation of cardiac pathological changes induced by chronic psychological stress. In vivo and in vitro experiments suggest that the corticosterone‐glucocorticoid receptor‐LAMA5 axis mediates cardiomyocyte hypertrophy induced by chronic psychological stress. The clinical results
Chuanjing Zhang, Yongfei Song, Xiaojun Jin, Qingbo Xu, Honghua Ye, Zhuonan Wu, Hui Lin, Jiale Hu, Chen Huang, Jianqing Zhou, Jiangfang Lian   +10 more
wiley   +1 more source

The DEC2‐SCN2A Axis is Essential for the Anticonvulsant Effects of Cannabidiol by Modulating Neuronal Plasticity

Advanced Science, EarlyView.
This study identifies DEC2 as a critical transcriptional repressor of Scn2a that directly binds E‐box motifs in its promoter to regulate neuronal plasticity and epileptogenesis. Functional manipulation of DEC2 alters seizure susceptibility in vivo. Cannabidiol enhances this repression, unveiling a novel DEC2‐SCN2A axis underlying its anticonvulsant ...
Huifang Song, Yifan Wang, Lili Wang, Chang Guo, Shiqi Liu, Yi Rong, Jiawen Tian, Chao Peng, Yuying Shao, Zhixiong Ma, Na Li, Jingliang Zhang, Zijun Peng, Xu Yan, Hangwei Fa, Xinyue Ma, Jie Dong, Jinping Ji, Chen Yang, Haocheng Chen, Jing Liang, Qi Sun, Yang Yang, Weining Ma, Zhuo Huang   +24 more
wiley   +1 more source

A Case of Hantavirus Renal Syndrome Detected in the COVID-19 Pandemic

Düzce Tıp Fakültesi Dergisi
Hantaviruses are enveloped RNA viruses in the Bunyaviridae family that cause rodent-borne zoonotic infections. They cause two separate diseases, hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS), as a result of ...
Nevin Ince, Yasemin Çakır
doaj   +1 more source