Results 181 to 190 of about 215,717 (294)

Stem cell–based therapies for type 1 diabetes: Progress in differentiation, clinical translation, and immune protection

Animal Models and Experimental Medicine, EarlyView.
Directed differentiation of pluripotent stem cells into functional pancreatic β cells have emerged as a promising strategy for the radical treatment of type 1 diabetes, with preclinical and early clinical evidence demonstrating reversal of hyperglycemia and insulin independence.
Zifan Li, Yu Kang, Yuyu Niu
wiley   +1 more source

Universal transcriptomic hallmarks of mammalian ageing and mortality. [PDF]

Nature
Tyshkovskiy A, Kholdina D, Davitadze M, Molière A, Moldakozhayev A, Tongu Y, Kasahara T, Glubokov D, Eames A, Kats LM, Vladimirova A, Ying K, Liu H, Zhang B, Khasanova U, Moqri M, Van Raamsdonk JM, Harrison DE, Strong R, Abe T, Dmitriev SE, Gladyshev VN.   +21 more
europepmc   +1 more source

Network „Rodent-borne pathogens“ in Germany: Longitudinal studies on the geographical distribution and prevalence of hantavirus infections

, 2007
Hartelt, U., Schlegel, M., Brockmann, S., Wenk, M., Wegener, W., Ulrich, Rainer G., Gerstengarbe, H. W., Pluta, S., Masur, D., Heckel, G., Pfeffer, M., Mikolajczak, S., Jacob, Jens, Sevke, K., Schmidt-Chanasit, J., Essbauer, S. S., Oehme, R., Pelz, Hans-Joachim, Mertens, M., Büchner, T.   +19 more
core  

Humanized immune system animal models and their recent applications

Animal Models and Experimental Medicine, EarlyView.
In this review, we provide an updated and comprehensive overview of the current state of humanized immune system animal model research. We discuss the variety of techniques used to produce humanized mice with their respective strengths and weaknesses, and evaluate the advantages and limitations of these models, including issues with incomplete immune ...
Nicolas Skuli, Rudra B. Amin, A’ishah Bakayoko, Marisa Kruidenier, Sahara Aqui, Sarah J. Skuli, Terence P. Gade   +6 more
wiley   +1 more source

A molecular survey of orthohantaviruses in rodents across the tri-border region of China, Russia, and North Korea. [PDF]

PLoS Negl Trop Dis
Peng Y, Gu Y, Li L, Zhang G, Liu Z, Liu N, Wang Z, Xu J, Wang Z.   +8 more
europepmc   +1 more source

Animal models of idiopathic membranous nephropathy: Recent advances and future perspectives

Animal Models and Experimental Medicine, EarlyView.
This review focuses on the evolution of idiopathic membranous nephropathy (IMN) animal models from traditional approaches (Heymann nephritis, C‐BSA, APA) to antigen‐specific models (PLA2R, THSD7A), critically evaluating their advances and limitations in replicating human IMN pathology.
Qiuying Liu, Huixian Bian, Jianhua Liu, Lina Wu, Zhijie Zhang, Hongli Zhao, Xiaosong Qin   +6 more
wiley   +1 more source

Hantavirus infections: an emerging zoonotic threat in the context of ecological change. [PDF]

New Microbes New Infect
Ong CJN, Cabuhat KSP, Fortaleza JAG, Dulay RMR.   +3 more
europepmc   +1 more source

Evaluation of cardiac histology and cell death markers during the progression of diabetes in a streptozotocin‐induced diabetes rat model

Animal Models and Experimental Medicine, EarlyView.
Daily insulin administration in streptozotocin‐induced diabetic rats prevented cardiac damage associated with diabetic cardiomyopathy, including hypertrophy, fibrosis, and expression of cell death markers, at 12 weeks. However, cyclophilin D, a marker of mitochondrial permeability transition pore‐opening‐associated cell death (necrosis), was observed ...
Tamara Sáez, Ivo Carrasco‐Wong, Juan Varas, Sebastián San Martín, Jaime A. Riquelme, Rienzi Díaz‐Navarro   +5 more
wiley   +1 more source

Local heterogeneity in Lassa fever serology in rural Nigeria: Implications for vaccine trial site selection. [PDF]

PLoS Negl Trop Dis
Simons D, Harden C, Imirzian N, Thompson KET, Ifebueme NM, Eziechina S, Ignatius H, Marcus D, Aderibigbe F, Koninga JT, Meremikwu M, Moses L, Redding DW, Friant S.   +13 more
europepmc   +1 more source

Animal models in molecular biology research: Challenges, ethical imperatives, and the path to human‐relevant translation

Animal Models and Experimental Medicine, EarlyView.
The graphical abstract shows how molecular biology research has shifted from using traditional animal models toward using methods that are more relevant to humans. It points out the main problems, differences between species, difficulty in reproducing results, moral issues, and lack of infrastructure that make translational accuracy harder to achieve ...
Md. Shajid Hossain Rafi, Md. Taslim Sarker, Ferdous‐Ul‐Haque Joy, Shahriar Mohd Shams, Tahmina Foyez, Md. Abdul Mazid, Syed Masudur Rahman Dewan   +6 more
wiley   +1 more source