Results 191 to 200 of about 341,043 (301)

Mechanosensitive Piezo1/Osteocalcin/Irisin Axis Protects Against Disuse‐Induced Muscle Atrophy

Advanced Science, EarlyView.
Mechanical unloading suppresses bone Piezo1 expression, which reduces circulating undercarboxylated osteocalcin (unOCN). unOCN reduction subsequently exacerbates IMM‐induced Fndc5/Irisin decrease and drives severe muscle atrophy. Bone Piezo1 activation or exogenous osteocalcin/Irisin ameliorate muscle atrophy, while muscle‐specific Gprc6a or Fndc5 ...
Zhaolu Wang, Xiuying Jiang, Xi Sun, Hao Chen, Jianjun Jin, Xin'e Shi   +5 more
wiley   +1 more source

Intestinal Source Control of Lipid Metabolism by Enzyme‐Probiotic Encapsulated, Spatiotemporal Crosslinked, and Small Intestine‐Adhesive Hydrogel Microspheres

Advanced Science, EarlyView.
A thiol‐modified alginate hydrogel microsphere‐encapsulated enzyme‐probiotic biohybrid (AKK‐COD) system has been developed to address the spatiotemporal delivery and colonization challenges of small intestine‐targeted probiotic for lipid metabolism regulation. The system exerts sequential functions of intragastric protection, small intestinal adhesion,
Xiaolin Wu, Weiwen Liang, Siqi He, Guangyuan Chen, Hui Zhou, Xinglong Wang, Yifei Li, Dingcai Wu, Bingna Zheng, Ruoxu Dou, Rongkang Huang   +10 more
wiley   +1 more source

Molecular detection and genetic diversity of hemotropic <i>Mycoplasma</i> species in synanthropic rodents across Thailand. [PDF]

Curr Res Parasitol Vector Borne Dis
Bulanawichit W, Rison K, Novianto D, Claude J, Ngamprasertwong T, Pimsai A, Kaewthamasorn M.   +6 more
europepmc   +1 more source

Paternal Caffeine Exposure Programs Offspring Stress Vulnerability via Sperm Dlk1‐Dio3 Imprinting‐Directed Remodeling of a Novel Neural Circuit

Advanced Science, EarlyView.
The study elucidates that paternal preconception stress can drive offspring hyperresponsivity of the stress system via hypomethylation of a specific DNA region in sperm. This key link is confirmed in a cohort of prospective fathers: the epigenetic alteration is associated with elevated stress hormone levels.
Mengxi Lu, Gaole Dai, Sen Zhu, Shuai Zhang, Tingting Wang, Yuan Meng, Fang Yang, Xiaoyi Han, Hui Wang, Hao Kou, Dan Xu   +10 more
wiley   +1 more source

Effectiveness of an Integrated One Health Intervention on <i>Schistosoma japonicum</i> Infection in Wild Rodents - Anhui Province, China, 2022-2024. [PDF]

China CDC Wkly
Guo S, Lyu C, Zhang L, Deng W, Xu J, Li S, Zhou X.   +6 more
europepmc   +1 more source

Rodent models of Alzheimer's disease

Progress in Neurobiology
Alzheimer's disease (AD) was first described over a century ago. However, the mechanisms underlying the disease are not well understood to this day. This has negatively impacted our ability to create animal models to design and test targeted reliable treatments for the disease.
Singhaarachchi, Pasindu Hansana, Antal, Peter, Calon, Frédéric, Culmsee, Carsten, Delpech, Jean-Christophe, Feldotto, Martin, Geertsema, Jorine, Hoeksema, Emmy E., Korosi, Aniko, Layé, Sophie, McQualter, Jonathan, de Rooij, Susanne R., Rummel, Christoph, Slayo, Mary, Sominsky, Luba, Spencer, Sarah J.   +15 more
openaire   +2 more sources

Wireless, Adaptable and Fully Implantable Battery‐powered Devices for Optical Stimulation of the Spinal Cord in Small Rodents

Advanced Science, EarlyView.
Current technologies for spinal cord optogenetic stimulation rely on external power sources and face reliability constraints in freely behaving animals. Here, a fully implantable, battery‐powered optoelectronic device is introduced, enabling operation in any selected environment with wireless recharging for months‐long stimulation.
Shahriar Shalileh, Adan Moallemi, Elham Mohseni Vadeghani, Samuel Tretjakov, Brianna Tsuyuki, Alexander Golab, Benjamin Rever, Wolfram Tetzlaff, Dena Shahriari   +8 more
wiley   +1 more source

Comparative evaluation of immunoserological detection of F-actin antibodies. [PDF]

PLoS One
Dellbrügge F, Loges S, Henjes N, Wedemeyer H, Taubert R, Engel B.   +5 more
europepmc   +1 more source

Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair

Advanced Science, EarlyView.
We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing, Yang Yang, Zichen Hong, Chunhui Tian, Huiyu Chu, Susanne Clara Prokop, Hongwei Cai, Mingxia Gu, Jason Tchieu, Ken Mackie, Feng Guo   +10 more
wiley   +1 more source

CIRAD's Platform in partnership (GREASE) activities on zoonoses in South East Asia [PDF]

, 2013
Binot, Aurélie, Cappelle, Julien, Chevalier, Véronique, Desquesnes, Marc, Duboz, Raphaël, Goutard, Flavie, Morand, Serge, Peyre, Marie-Isabelle, Roger, François   +8 more
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