Results 251 to 260 of about 2,405,598 (288)

Rodent models for Alzheimer disease

Nature Reviews Neuroscience, 2018
Animal models are indispensable tools for Alzheimer disease (AD) research. Over the course of more than two decades, an increasing number of complementary rodent models has been generated. These models have facilitated testing hypotheses about the aetiology and progression of AD, dissecting the associated pathomechanisms and validating therapeutic ...
Jürgen Götz, Liviu-Gabriel Bodea, Michel Goedert   +2 more
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Rodent and Non-Rodent Animal Models for CardioVascular Diseases

2022
Cardiovascular diseases (CVD) come under non-communicable disease (NCD) that are responsible for the leading cause of death, globally. They involve a range of pathologies viz. coronary artery disease, cerebro-vascular disease, venous thrombo-embolism, peripheral vascular disease, myocardial infarction, cardiac arrhythmias and stroke.
Irfan Ahmad Mir, HV Manjunathachar, R Ravinda Naik, SSYH Qadri, Taniya Saleem   +4 more
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Endocrine Diseases of Rodents

Veterinary Clinics of North America: Exotic Animal Practice, 2008
The frequency of documented endocrine diseases in rodents and other small mammals varies considerably among the species maintained as pets, biomedical research animals, or display animals in zoos. The clinical diagnosis of endocrine diseases almost never occurs in free-ranging animals in their native habitat.
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Dental Disease in Rodents

Journal of Veterinary Dentistry, 1990
The dental diseases of rodents are unique because of their dental anatomy and physiology. Common problems of rodent dentitions are covered in this article including periodontal disease, stomatitis, caries, and malocclusions. The anatomy of rodent dentitions is reviewed. Treatment for these diseases is included.
Robert B. Wiggs, Heidi B. Lobprise
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Thyroid Diseases in Rodent Species

Veterinary Clinics of North America: Exotic Animal Practice, 2014
There are an abundance of studies of thyroid disease in rodents in a laboratory setting; however, research is limited in pet rodent populations. Validated reference intervals for thyroid testing are scarce, making interpretation of blood work difficult. Hyperthyroidism and hypothyroidism have been reported in multiple rodent species, with the most data
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Thyroid Disease in Rabbits and Rodents

Veterinary Clinics of North America: Exotic Animal Practice
While thyroid disease is generally uncommon in rabbits and rodents, it is most frequently diagnosed in guinea pigs. Particularly, hyperthyroidism and thyroid neoplasms are diagnosed regularly in this species, while thyroid neoplasia is the most common thyroid disorder found in other rodents.
Milena, Thöle, Tina, Brezina
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Fungal diseases of laboratory rodents

Veterinary Clinics of North America: Exotic Animal Practice, 2003
Although fungal disease is uncommon in rodents, dermatophytosis is the most common mycosis seen in clinical practice. T. mentagrophytes is the most common etiologic agent, and the guinea pig is the most common species affected, although there are reports in all pet and laboratory rodent species except the gerbil.
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Promising rodent models in Parkinson's disease

Parkinsonism & Related Disorders, 2018
In the past decade, the study of the pathogenic mechanisms underlying neurodegeneration in Parkinson's disease (PD) has revealed a genetic component, often associated with a number of environmental risk factors. Animal models have improved our understanding of disease pathogenesis, providing significant insights into the understanding of novel ...
Imbriani P., Sciamanna G., Santoro M., Schirinzi T., Pisani A.   +4 more
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Overview on Rodent Models of Alzheimer's Disease

Current Protocols in Neuroscience, 2005
AbstractIn Alzheimer's disease (AD), characteristic lesions develop in brain regions that subserve cognitive functions, ultimately leading to dementia. There are now several lesioned or transgenic small‐animal models of the disease that model select aspects of cognitive deficits and/or recapitulate many, but not all, of the characteristic pathologic ...
Jean-Cosme, Dodart, Patrick, May
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Pharmacological Models of Parkinson’s Disease in Rodents

2011
Parkinson's disease (PD) is one of the most common neurodegenerative disorders. Despite the substantial progress that has been achieved, the precise mechanisms involved in the development of this disease are still not fully understood. The most common concepts relate to the genetic background and environmental/toxic effects.
Peter, Klivenyi, Laszlo, Vecsei
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