Results 11 to 20 of about 9,520,639 (370)

Effect of rodent density on tick and tick-borne pathogen populations: consequences for infectious disease risk

Parasites & Vectors, 2020
Background Rodents are considered to contribute strongly to the risk of tick-borne diseases by feeding Ixodes ricinus larvae and by acting as amplifying hosts for pathogens. Here, we tested to what extent these two processes depend on rodent density, and
Aleksandra I. Krawczyk, Gilian L. A. van Duijvendijk, Arno Swart, Dieter Heylen, Ryanne I. Jaarsma, Frans H. H. Jacobs, Manoj Fonville, Hein Sprong, Willem Takken   +8 more
doaj   +2 more sources

Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer’s disease in rodent models [PDF]

Nature Communications, 2016
Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase-1 (COX-1) and COX-2 enzymes. The NLRP3 inflammasome is a multi-protein complex responsible for the processing of the proinflammatory cytokine interleukin-1β and is implicated in many ...
Michael J. Daniels, Jack Rivers‐Auty, Tom Schilling, Nicholas G. Spencer, William Watremez, Victoria Fasolino, Sophie J. Booth, Claire White, Alex G. Baldwin, Sally Freeman, Raymond Wong, Clare Latta, Yu Shi, Joshua Jackson, Nicolas Fischer, Violette Koziel, Thierry Pillot, James Bagnall, Stuart M. Allan, Pawel Paszek, James Galea, Michael Harte, Claudia Eder, Catherine B. Lawrence, David Brough   +24 more
openalex   +2 more sources

Community-led intensive trapping reduces abundance of key plague reservoir and flea vector [PDF]

Tropical Medicine and Health
Background Zoonotic pathogens transmitted by rodents are highly prevalent in low-middle income countries and effective control measures that are easily implemented are urgently needed.
Marcela P. A. Espinaze, Soanandrasana Rahelinirina, Todisoa Radovimiandrinifarany, Fehivola Mandanirina Andriamiarimanana, Alain Berthin Andrianarisoa, Voahangy Soarimalala, Kathryn Scobie, Mireille Harimalala, Minoarisoa Rajerison, Steven R. Belmain, Sandra Telfer   +10 more
doaj   +2 more sources

Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases

Nature Communications, 2023
Microglial activation plays central roles in neuroinflammatory and neurodegenerative diseases. Positron emission tomography (PET) targeting 18 kDa Translocator Protein (TSPO) is widely used for localising inflammation in vivo, but its quantitative ...
E. Nutma, N. Fancy, M. Weinert, S. Tsartsalis, M. Marzin, R. Muirhead, Irene Falk, M. Breur, Joy de Bruin, David Hollaus, Robin Pieterman, J. Anink, David J. Story, S. Chandran, Jiabin Tang, M. C. Trolese, T. Saito, T. Saido, Katharine H. Wiltshire, Paula Beltran-Lobo, Alexandra E. M. Phillips, J. Antel, Luke M. Healy, Marie-France Dorion, D. Galloway, Rochelle Y. Benoit, Quentin Amossé, Kelly Ceyzériat, Aurélien M. Badina, E. Kövari, C. Bendotti, E. Aronica, Carola I. Radulescu, J. Wong, A. Barron, Amy M. Smith, Samuel J. Barnes, D. Hampton, P. Van Der Valk, S. Jacobson, O. Howell, D. Baker, M. Kipp, Hannes Kaddatz, B. Tournier, P. Millet, P. Matthews, C. Moore, S. Amor, D. Owen   +49 more
semanticscholar   +1 more source

Validation of Reference Genes via qRT-PCR in Multiple Conditions in Brandt’s Voles, Lasiopodomys brandtii

Animals, 2021
The choice of optimal reference gene is challenging owing to the varied expression of reference genes in different organs, development stages, and experimental treatments. Brandt’s vole (Lasiopodomys brandtii) is an ideal animal to explore the regulatory
Lin Tian, Yan Chen, Da-Wei Wang, Xiao-Hui Liu   +3 more
doaj   +1 more source

No Evidence for the Presence of SARS-CoV-2 in Bank Voles and Other Rodents in Germany, 2020–2022

Pathogens, 2022
Rodentia is the most speciose mammalian order, found across the globe, with some species occurring in close proximity to humans. Furthermore, rodents are known hosts for a variety of zoonotic pathogens. Among other animal species, rodents came into focus
Kerstin Wernike, Stephan Drewes, Calvin Mehl, Christin Hesse, Christian Imholt, Jens Jacob, Rainer G. Ulrich, Martin Beer   +7 more
doaj   +1 more source

Behavioral tests for evaluating the characteristics of brain diseases in rodent models: Optimal choices for improved outcomes (Review).

Molecular Medicine Reports, 2022
Behavioral assessment is the dominant approach for evaluating whether animal models of brain diseases can successfully mimic the clinical characteristics of diseases.
Lingyi Huang, Dongqiong Xiao, Hao Sun, Y. Qu, Xiaojuan Su   +4 more
semanticscholar   +1 more source

Effects of angiogenic factor overexpression by human and rodent cholangiocytes in polycystic liver diseases [PDF]

Hepatology, 2006
Luca Fabris, Massimiliano Cadamuro, Romina Fiorotto, Tania Roskams, Carlo Spirlı̀, Saida Melero, Aurelio Sonzogni, Ruth Joplin, Lajos Okolicsànyi, Mario Strazzabosco   +9 more
openalex   +2 more sources

Land-use change and rodent-borne diseases: hazards on the shared socioeconomic pathways

Philosophical Transactions of the Royal Society of London. Biological Sciences, 2021
Land-use change has a direct impact on species survival and reproduction, altering their spatio-temporal distributions. It acts as a selective force that favours the abundance and diversity of reservoir hosts and affects host–pathogen dynamics and ...
GE García-Peña, AV Rubio, MT Milholland, C. Zambrana‐Torrelio, G. García‐Peña, André V. Rubio, Hugo Mendoza, Miguel Fernandez, Matthew T. Milholland, A. A. Aguirre, G. Suzán   +10 more
semanticscholar   +1 more source

Modeling Parkinson’s Disease: Not Only Rodents? [PDF]

Frontiers in Aging Neuroscience, 2021
Parkinson’s disease (PD) is a common chronic progressive multifactorial neurodegenerative disease. In most cases, PD develops as a sporadic idiopathic disease. However, in 10%–15% of all patients, Mendelian inheritance of the disease is observed in an autosomal dominant or autosomal recessive manner.
Petr A. Slominsky, Maria I. Shadrina
openaire   +4 more sources