Results 21 to 30 of about 341,043 (301)
Scientific Reports, 2021 Zoonotic diseases, caused by pathogens transmitted between other vertebrate animals and humans, pose a major risk to human health. Rodents are important reservoir hosts for many zoonotic pathogens, and rodent population dynamics affect the infection ...
Mahdi Aminikhah +7 more
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Rodent Models of Huntington’s Disease: An Overview
Biomedicines, 2023 Huntington’s disease (HD) is an autosomal-dominant inherited neurological disorder caused by a genetic mutation in the IT15 gene. This neurodegenerative disorder is caused by a polyglutamine repeat expansion mutation in the widely expressed huntingtin (HTT) protein.
Giulio Nittari +7 more
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Rodent models for prion diseases [PDF]
Veterinary Research, 2008 Until today most prion strains can only be propagated and the infectivity content assayed by experimentally challenging conventional or transgenic animals. Robust cell culture systems are not available for any of the natural and only for a few of the experimental prion strains.
Groschup, Martin, Buschmann, Anne
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Modeling Parkinson’s disease in LRRK2 rodents
Neuronal Signaling, 2023 Abstract Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are associated with familial and sporadic forms of Parkinson’s disease (PD). Sporadic PD and LRRK2 PD share main clinical and neuropathological features, namely hypokinesia, degeneration of nigro-striatal dopamine neurons and α-synuclein aggregates in the form of Lewy ...
Domenicale, Chiara +2 more
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Bacterial and viral rodent-borne infections on poultry farms. An attempt at a systematic review
Journal of Veterinary Research, 2023 Rodents are quite common at livestock production sites. Their adaptability, high reproductive capacity and omnivorousness make them apt to become a source of disease transmission to humans and animals.
Domanska-Blicharz Katarzyna +3 more
doaj +1 more source
Modeling Parkinson’s Disease: Not Only Rodents? [PDF]
Frontiers in Aging Neuroscience, 2021 Parkinson’s disease (PD) is a common chronic progressive multifactorial neurodegenerative disease. In most cases, PD develops as a sporadic idiopathic disease. However, in 10%–15% of all patients, Mendelian inheritance of the disease is observed in an autosomal dominant or autosomal recessive manner.
Maria Shadrina, Petr Slominsky
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Journal of Small Animal Practice, 1980 ABSTRACTThe main pet rodent species are introduced with some brief notes on their suitability as pets and normal behaviour. The general clinical features of disease are discussed with some emphasis on species variation. The important diseases that occur in the United Kingdom are described under the headings of respiratory disease, diseases of the ...
openaire +2 more sources
Scientific Reports, 2022 Rodents living alongside humans increases the probability of encounter and also the transmission of rodent-borne diseases. Singapore’s cosmopolitan urban landscape provides a perfect setting to study the prevalence of four rodent-borne pathogens: Seoul ...
Jane Griffiths +8 more
doaj +1 more source
Risk factors for human acute leptospirosis in northern Tanzania [PDF]
, 2018 Introduction: Leptospirosis is a major cause of febrile illness in Africa but little is known about risk factors for human infection. We conducted a cross-sectional study to investigate risk factors for acute leptospirosis and Leptospira ...
Allan, Kathryn J. +16 more
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Feline Hypertrophic Cardiomyopathy: A Spontaneous Large Animal Model of Human HCM. [PDF]
, 2017 Hypertrophic cardiomyopathy (HCM) is a common disease in pet cats, affecting 10-15% of the pet cat population. The similarity to human HCM, the rapid progression of disease, and the defined and readily determined endpoints of feline HCM make it an ...
Freeman, Lisa M +4 more
core +2 more sources