Results 21 to 30 of about 210,135 (261)
Rodent Models of Huntington’s Disease: An Overview
Biomedicines, 2023 Huntington’s disease (HD) is an autosomal-dominant inherited neurological disorder caused by a genetic mutation in the IT15 gene. This neurodegenerative disorder is caused by a polyglutamine repeat expansion mutation in the widely expressed huntingtin (HTT) protein.
Giulio Nittari +7 more
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Modeling Parkinson’s disease in LRRK2 rodents
Neuronal Signaling, 2023 Abstract Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are associated with familial and sporadic forms of Parkinson’s disease (PD). Sporadic PD and LRRK2 PD share main clinical and neuropathological features, namely hypokinesia, degeneration of nigro-striatal dopamine neurons and α-synuclein aggregates in the form of Lewy ...
Domenicale, Chiara +2 more
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Rodent models for prion diseases [PDF]
Veterinary Research, 2008 Until today most prion strains can only be propagated and the infectivity content assayed by experimentally challenging conventional or transgenic animals. Robust cell culture systems are not available for any of the natural and only for a few of the experimental prion strains.
Groschup, Martin, Buschmann, Anne
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Bacterial and viral rodent-borne infections on poultry farms. An attempt at a systematic review
Journal of Veterinary Research, 2023 Rodents are quite common at livestock production sites. Their adaptability, high reproductive capacity and omnivorousness make them apt to become a source of disease transmission to humans and animals.
Domanska-Blicharz Katarzyna +3 more
doaj +1 more source
Modeling Parkinson’s Disease: Not Only Rodents? [PDF]
Frontiers in Aging Neuroscience, 2021 Parkinson’s disease (PD) is a common chronic progressive multifactorial neurodegenerative disease. In most cases, PD develops as a sporadic idiopathic disease. However, in 10%–15% of all patients, Mendelian inheritance of the disease is observed in an autosomal dominant or autosomal recessive manner.
Maria Shadrina, Petr Slominsky
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Journal of Small Animal Practice, 1980 ABSTRACTThe main pet rodent species are introduced with some brief notes on their suitability as pets and normal behaviour. The general clinical features of disease are discussed with some emphasis on species variation. The important diseases that occur in the United Kingdom are described under the headings of respiratory disease, diseases of the ...
openaire +2 more sources
Scientific Reports, 2022 Rodents living alongside humans increases the probability of encounter and also the transmission of rodent-borne diseases. Singapore’s cosmopolitan urban landscape provides a perfect setting to study the prevalence of four rodent-borne pathogens: Seoul ...
Jane Griffiths +8 more
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Rodent-borne diseases in Thailand: targeting rodent carriers and risky habitats [PDF]
Infection Ecology & Epidemiology, 2012 Comparative analysis, which aims at investigating ecological and evolutionary patterns among species, may help at targeting reservoirs of zoonotic diseases particularly in countries presenting high biodiversity. Here, we developed a simple method to target rodent reservoirs using published studies screening microparasite infections.We compiled surveys ...
Herbreteau, Vincent +4 more
openaire +7 more sources
PLoS ONE, 2022 Vector control remains an important strategy in preventing rodent-borne diseases. Studies quantifying the impact of anticoagulant bait use on rodent populations are scarce in tropical settings.
Stacy Soh +7 more
doaj +1 more source
Tropical Medicine and Infectious Disease, 2021 The plague caused by the Yersinia pestis bacterium is primarily a flea-transmitted zoonosis of rodents that can also be conveyed to humans and other mammals.
Diego Leandro Reis da Silva Fernandes +6 more
doaj +1 more source