Results 151 to 160 of about 211,794 (261)

Sleep deprivation: a comprehensive review of multisystem impacts, underlying mechanisms, and emerging interventions. [PDF]

Front Neurol
Fan YZ, Liu GD, Zhang AN, Wang Y, Cheng YQ.   +4 more
europepmc   +1 more source

Rocket‐Inspired Sequentially Targeted Nanotherapeutics for Mitochondrial Regulation and Inflammatory Reprogramming in Ischemic Stroke

Advanced Science, EarlyView.
A novel neutrophil‐hitchhiking, rocket‐inspired nanoplatform is developed to cross the blood‐brain barrier for sequential, spatiotemporal drug delivery. By responsive surface transformation in the ischemic penumbra, it precisely targets mitochondria to suppress Drp1‐mediated fission.
He Bai, Zihao Yong, Yang Li, Qingmin Chen, Yong Liu, Xiaomeng Guo, Fukai Li, Shicheng Tang, Zhuo Yang, Yufei Zhang, Ruwei Jie, Xiaohong Lv, Huacheng Wang, Chunming Huang, Liwei Xie, Jianqi Xiao, Qingchun Mu, Longguang Tang   +17 more
wiley   +1 more source

Serological evidence of Lassa virus in commensal rodents from Senegal. [PDF]

BMC Infect Dis
Seye S, Kane M, Sankhe S, Dia N, Fall G, Faye O, Diallo M, Gaye A, Diagne MM.   +8 more
europepmc   +1 more source

Rodent models of Alzheimer's disease

Progress in Neurobiology
Alzheimer's disease (AD) was first described over a century ago. However, the mechanisms underlying the disease are not well understood to this day. This has negatively impacted our ability to create animal models to design and test targeted reliable treatments for the disease.
Singhaarachchi, Pasindu Hansana, Antal, Peter, Calon, Frédéric, Culmsee, Carsten, Delpech, Jean-Christophe, Feldotto, Martin, Geertsema, Jorine, Hoeksema, Emmy E., Korosi, Aniko, Layé, Sophie, McQualter, Jonathan, de Rooij, Susanne R., Rummel, Christoph, Slayo, Mary, Sominsky, Luba, Spencer, Sarah J.   +15 more
openaire   +2 more sources

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

Advanced Science, EarlyView.
Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl, David Holubek, Klaus Speck, Raphael Wildermuth, Franz‐Lucas Haut, Stephan Permann, Immanuel Plangger, Christian Steinborn, Zhigang Rao, Danilo D'Avino, Ida Cerqua, Julia Stadler, Fiorentina Roviezzo, Peter Schlenke, Anita Siller, Harald Schennach, Solveigh C. Koeberle, Eva‐Maria Pferschy‐Wenzig, Antonietta Rossi, Thomas Magauer, Andreas Koeberle   +20 more
wiley   +1 more source

Hantavirus seroprevalence and associated factors for exposure in south-central Uganda. [PDF]

Emerg Microbes Infect
Katushabe G, Ssempijja V, Rao D, Nalwadda J, Rosenke K, Reynolds SJ, Omooja J, Biraro IA, Grabowski MK, Mihalakakos EA, Galiwango RM, Ssekubugu R, Byarugaba DK, Feldmann H, Hawman DW.   +14 more
europepmc   +1 more source

Magnetoelectric Nanoparticles Enable Modulation of Cortical Networks by Low‐Intensity Static Magnetic Fields In Vitro

Advanced Science, EarlyView.
Neuromodulation strategies are increasingly needed to stimulate, restore, or replace altered neuronal activity in disease. Cobalt ferrite‐barium titanate (CFO–BTO) magnetoelectric nanoparticles convert low‐intensity static magnetic fields into local electrical modulation of cortical networks.
Nathalia Cancino‐Fuentes, Alejandro Suarez‐Perez, Elric Zhang, Hao Ye, Marta Bonato, Joana Covelo, Vitaly Pustovalov, Anton Guimera‐Brunet, Xavi Illa, Valentin Gantenbein, Cagatay M. Oral, Marta Parazzini, Salvador Pané, Maria V. Sanchez‐Vives   +13 more
wiley   +1 more source

Local heterogeneity in Lassa fever serology in rural Nigeria: Implications for vaccine trial site selection. [PDF]

PLoS Negl Trop Dis
Simons D, Harden C, Imirzian N, Thompson KET, Ifebueme NM, Eziechina S, Ignatius H, Marcus D, Aderibigbe F, Koninga JT, Meremikwu M, Moses L, Redding DW, Friant S.   +13 more
europepmc   +1 more source

Long Noncoding RNA PCALRx Interacts with Pyruvate Carboxylase to Drive Multi‐Organ Developmental Toxicity in Zebrafish Embryos Exposed to Amoxicillin

Advanced Science, EarlyView.
Embryonic amoxicillin exposure disrupts multi‐organ development in zebrafish larvae through a lncRNA–metabolic enzyme regulatory axis. PCALRx associates with pyruvate carboxylase, promotes PC protein ubiquitination, and impairs mitochondrial energy metabolism, while vitamin B1 partially restores PC‐centered metabolic function and developmental outcomes.
Yixue Yao, Ping Jiang, Xinli Zhou, Mengying Yin, Qiong Luo, Hui Wang   +5 more
wiley   +1 more source

Hantavirus infections: an emerging zoonotic threat in the context of ecological change. [PDF]

New Microbes New Infect
Ong CJN, Cabuhat KSP, Fortaleza JAG, Dulay RMR.   +3 more
europepmc   +1 more source