Results 181 to 190 of about 2,409,751 (295)

Rodent models of Alzheimer's disease

Progress in Neurobiology
Alzheimer's disease (AD) was first described over a century ago. However, the mechanisms underlying the disease are not well understood to this day. This has negatively impacted our ability to create animal models to design and test targeted reliable treatments for the disease.
Singhaarachchi, Pasindu Hansana, Antal, Peter, Calon, Frédéric, Culmsee, Carsten, Delpech, Jean-Christophe, Feldotto, Martin, Geertsema, Jorine, Hoeksema, Emmy E., Korosi, Aniko, Layé, Sophie, McQualter, Jonathan, de Rooij, Susanne R., Rummel, Christoph, Slayo, Mary, Sominsky, Luba, Spencer, Sarah J.   +15 more
openaire   +2 more sources

Arrayed Magnetic Accelerator Synergistically Enhances Orthodontic Tooth Movement via Microtubule Assembly‐Mediated Periodontal Remodeling

Advanced Science, EarlyView.
Mechanical orthodontic treatment for malocclusion is limited by slow remodeling and risks due to poor biomechanical sensing. This study shows that static magnetic fields (SMFs) enhance mechanical sensation in periodontal ligament cells, promoting inflammation and osteoclast activity.
Yiling Lou, Jiwei Sun, Peng Chen, Caihong Mao, Junyuan Zhang, Haoqi Lei, Xiaoqing Han, Yaxuan Zhang, Yuheng Jiang, Yulin Jia, Bin Su, Lili Chen   +11 more
wiley   +1 more source

Rattus norvegicus and Rattus tanezumi as hub hosts for viral diversity and potential spillover on Hainan Island, China. [PDF]

NPJ Biofilms Microbiomes
Huangfu H, Pu J, Jiao M, Fan Q, Deng H, Ling Q, Zhou H, Luo X, Xu J.   +8 more
europepmc   +1 more source

Deubiquitination of Vangl by USP6 and USP32 Regulates Planar Cell Polarity Signaling

Advanced Science, EarlyView.
Compartment‐specific deubiquitination controls Vangl dosage and planar cell polarity signaling. USP6 and USP32 regulate distinct subcellular pools of Vangl by removing distinct ubiquitin modifications from Vangl proteins. This regulatory mechanism safeguards PCP‐dependent embryonic morphogenesis, while aberrant USP32‐dependent stabilization of VANGL ...
Fangzi Zha, Di Feng, Ziru Xue, Zhiying Liu, Xiaochen Lin, Zhe Wang, Ling Xu, Jasper Fuk Woo Chan, Martin Cheung, Michael Shing Yan Huen, Yusong Guo, Kui Ming Chan, Yun Liu, Bo Gao   +13 more
wiley   +1 more source

Correction to "PFAS Toxicity: What's True, What's Not, and What Really Matters". [PDF]

Environ Sci Technol
DeWitt JC, Cousins IT, Goldenman G, Herzke D, Lohmann R, Miller M, Ng CA, Scheringer M, Trier X, Wang Z.   +9 more
europepmc   +1 more source

Network „Rodent-borne pathogens“ in Germany: Longitudinal studies on the geographical distribution and prevalence of hantavirus infections

, 2007
Hartelt, U., Schlegel, M., Brockmann, S., Wenk, M., Wegener, W., Ulrich, Rainer G., Gerstengarbe, H. W., Pluta, S., Masur, D., Heckel, G., Pfeffer, M., Mikolajczak, S., Jacob, Jens, Sevke, K., Schmidt-Chanasit, J., Essbauer, S. S., Oehme, R., Pelz, Hans-Joachim, Mertens, M., Büchner, T.   +19 more
core  

TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss

Advanced Science, EarlyView.
TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale, Barbara Vona, Richard J. Goodyear, Richard T. Osgood, Jun Shen, Sami S. Amr, Karen Mojica, Michaela A. H. Hofrichter, Jörg Schröder, Sophie Flandin, Paul Gratias, Ricardo Vera‐Monroy, Katherine Callahan, Kerry L. Gudlewski, Rolen Quadros, Masato Ohtsuka, JoAnn McGee, Edward J. Walsh, Cynthia C. Morton, Thomas Haaf, Channabasavaiah Gurumurthy, James E. Saunders, Guy P. Richardson, Artur A. Indzhykulian   +23 more
wiley   +1 more source

Increasing spatial scale of analysis weakens and can mask the dilution effect for hantaviruses. [PDF]

PLOS Glob Public Health
Vigueras-Galván AL, Arnathau C, Rico-Chávez O, Milholland MT, Vargas ML, Suzán G, Zambrana-Torrelio C, Castro-Arellano I, Mills JN, Morales ME, Villanueva HZ, Roche B, Arnal A.   +12 more
europepmc   +1 more source

Leveraging Microphysiological Systems to Facilitate Neutrophil‐Based Cancer Immunotherapy

Advanced Science, EarlyView.
Microphysiological systems are emerging as powerful human‐relevant platforms for studying neutrophil biology in cancer. Current applications of spheroids, organoids, and organ‐on‐a‐chip models are reviewed, together with future opportunities in behaviorome profiling, multi‐omics integration, personalized medicine, immune crosstalk, and multi‐organ ...
Shuai Shao, Markus Isfeld Diehl, Caroline N. Jones   +2 more
wiley   +1 more source

Development of a Novel Quantitative PCR Assay for Detecting <i>Schistosoma japonicum</i> in Field-Captured Rodents. [PDF]

Pathogens
Lv C, Jia J, Xu X, Li S, Sun Q, Xu J, Lin L, Liu Q, Hong Y.   +8 more
europepmc   +1 more source