Results 201 to 210 of about 2,409,751 (295)

Mitochondria‐Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation

Advanced Science, EarlyView.
This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Yuanyuan Su, Zhiyan Gong, Jiao Mu, Lili Huang, Pengfei Yang, Chenli Zhang, Lingshan Zhao, Liling Yang, Jun Deng, Xiaohui Liao   +9 more
wiley   +1 more source

Climate change and zoonotic spillover: lessons from recent hantavirus events. [PDF]

BMC Glob Public Health
Hu W, Gan T.
europepmc   +1 more source

An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2

Advanced Science, EarlyView.
Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu, Hongkun Wang, Jiawei Wang, Xiaolu Liu, Aerziguli Aierken, Lizhen Xu, Ping Liang, Fan Yang   +7 more
wiley   +1 more source

Emerging Mammarenaviruses in Wildlife: Expanding Host Range and Implications. [PDF]

Animals (Basel)
Di Martino B, Carnevale M, Corsi L, Sarchese V, Pellegrini F, Smoglica C, Petrini A, Martella V, Marsilio F, Di Profio F.   +9 more
europepmc   +1 more source

Adaptive Network Stabilization Despite Profound Structural Reorganization in Human Organotypic Cultures

Advanced Science, EarlyView.
Adult human organotypic cortical slices undergo marked neuronal loss, laminar disruption, and glial activation, yet their network activity progressively stabilizes after a variable period. Electrophysiology, longitudinal calcium imaging, and quantitative histology show that structurally remodeled human circuits show adaptive capacity resulting in ...
Estilla Zsófia Tóth, Rebeka Stelcz, Réka Bod, Ábel Petik, Eszter Juhász, Kinga Tóth, Liza Szalai, Nour Essam, Fanni Somogyi, Beatrix Kovács, Amirmahdi Mojtahedzadeh, Attila György Bagó, Loránd Erőss, Péter Orbay, Johanna Petra Szabó, Dániel Fabó, Boglárka Hajnal, Bence Rácz, Daniel Hillier, István Ulbert, Lucia Wittner   +20 more
wiley   +1 more source

Emergence of zoonotic <i>Cryptosporidium</i>, <i>Giardia duodenalis</i> and <i>Enterocytozoon bieneusi</i> in wild rodent from Yunnan: first detection of <i>C. parvum</i> IIdA24G1 in wild rodents in China. [PDF]

Front Microbiol
Duan R, Shu F, Sun Z, Wang P, Li H, Deng M, Wei P, Wang X, Zou F, Yang J, Wang L.   +10 more
europepmc   +1 more source

Advances in Aptamer Drug Delivery Systems for Treatment of Glioblastoma

Advanced Science, EarlyView.
Aptamers have remarkable recognition capacity which is suitable for assisting drug delivery for GB. This review demonstrates that aptamers have great potential as targeted therapeutic carriers, conjugated to various therapeutic carriers, using a range of conjugation strategies and chemistries.
Alexandra R. Paul, Alexandra Moreno Mitchell, Dean O'Neil, Yutong Luo, Khuloud T. Al‐Jamal   +4 more
wiley   +1 more source

Entropy of the resting state cortex in epilepsy. [PDF]

Biomed Phys Eng Express
Kaur K, O'Brien-Cairney J, Singh G, Upadhya MA, Chakraborty A, Chandra PS, Prüss H, Kornau HC, Schmitz D, Woodhall G, Rosch R, Angelova M, Seri S, Tripathi M, Wright SK, Witton C.   +15 more
europepmc   +1 more source

Acid‐Responsive Nanobot‐Integrated Core‐Shell Microneedles Reprogram the Degenerative Annulus Fibrosus Microenvironment Through Epigenetic Suppression of Ferroptosis

Advanced Science, EarlyView.
An acid‐responsive core‐shell microneedle system normalizes the degenerative annulus fibrosus microenvironment by consuming pathological H+, generating O2, and providing NIR‐amplified redox buffering. Mechanistically, it epigenetically suppresses ferroptosis via DNMT3A‐dependent methylation of the ATF3 promoter, relieving ATF3‐mediated repression of ...
Lu Tan, Yan Zheng, Yue Lan, Zhuo Cheng, Siya Wang, Changqing Li, Yanqiu Wang, Minghan Liu   +7 more
wiley   +1 more source

Scaling Lassa Virus Dynamics within Anthropogenic Ecosystems (SCAPES) Study Protocol: a mixed-methods observational cohort study of humans, rodents, and landscapes in Nigeria. [PDF]

Wellcome Open Res
Friant S, Simons D, Harden C, Imirzian N, Bjornstad O, Gibb R, Jones K, Smith A, Thompson K, Lever A, Aderibigbe F, Ayambem W, Ifebueme N, Ignatius H, Koninga J, Meremikwu M, Moses L, Redding D.   +17 more
europepmc   +1 more source