Results 111 to 120 of about 2,281,205 (316)
QBP1 Peptide as a Potential Anti‐Amyloidogenic Therapy for Type 2 Diabetes: An In Vitro Study
Advanced Science, EarlyView.The anti‐amyloidogenic peptide QBP1 effectively halts human islet amyloid polypeptide (hIAPP) aggregation, preventing the formation of toxic β‐structured intermediates. Through a combination of biophysical assays, molecular dynamics, and cell‐based studies, QBP1 is shown to preserve β‐cell viability and metabolic homeostasis, positioning it as a ...
María M. Tejero‐Ojeda +8 more
wiley +1 more source
In Vivo Microplastic Detection With Photoacoustic Imaging
Advanced Science, EarlyView.ABSTRACT Microplastics are posing an escalating threat to both ecological systems and human health. Yet, current methods for investigating their bioaccumulation are highly invasive, requiring destructive analysis of ex vivo tissues via mass spectrometry, dye labelling, or Raman microspectroscopy.
Joseph C. Bear +9 more
wiley +1 more source
, 2015 . In this article we review literature-based data on energy metabolism of caviomorph species in a changing world. The pioneer work of Arends and McNab (2001) analyzed the energetics of 30 caviomorph species, specifically the effect of their food habits ...
Luna, Facundo +2 more
core
, 2011 This work was supported by The Wellcome Trust [grant 078405/Z/05/Z]n humans, novelty-seeking behavior peaks in adolescence and is higher in males than females.
Gillian R. Brown +3 more
core +1 more source
Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs
Advanced Science, EarlyView.Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou +22 more
wiley +1 more source
Leucine aminopeptidase1 controls egg deposition and hatchability in male Aedes aegypti mosquitoes
Nature CommunicationsAedes aegypti are vectors for several arboviruses infecting hundreds of millions of people annually. Controlling mosquito populations by regulating their reproduction is a potential strategy to minimize viral transmission in the absence of effective ...
Xiaomei Sun +6 more
doaj +1 more source
Advanced Science, EarlyView.Fibronectin 1 (FN1)‐expressing subicular subpopulations encode novel object preference and selectively govern retrieval of novel object recognition (NOR) via affecting excitability of entorhinal‐projecting circuit through large conductance Ca2+‐activated potassium (BK) channel. ABSTRACT Novel object recognition (NOR), referring to the cognitive ability
Fan Fei +15 more
wiley +1 more source
The ecological, physiological and species-specific characteristics of the leukocyte profile of two species of cyclomorphic rodents, the bank vole Myodes glareolus (Schreber, 1780) and the pygmy wood mouse Apodemus uralensis (Pallas, 1811), were studied ...
Klimova A.S., Sirotina M.V.
core +1 more source
Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain
Advanced Science, EarlyView.This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao +7 more
wiley +1 more source