Results 91 to 100 of about 1,891,300 (298)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Security Aspects for Business Solution Development on Portal Technology [PDF]

Database Systems Journal, 2012
In the scope of portal development, in order to talk about security issues, concerns, and solutions, it is necessary to define a few terms: authentication, authorization, Single Sign-On (SSO), confidentiality, integrity, and non-repudiation.
Ovidiu RĂDUTĂ, Adrian MUNTEANU
doaj  

CA‐ARBAC: privacy preserving using context‐aware role‐based access control on Android permission system [PDF]

, 2016
Juhar Abdella, Mustafa Özuysal, Emrah Tomur   +2 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

The Equivalent Conversions of the Role-Based Access Control Model [PDF]

, 2018
Н.Ф. Богаченко
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Building Trust in Conversational AI: A Review and Solution Architecture Using Large Language Models and Knowledge Graphs

Big Data and Cognitive Computing
Conversational AI systems have emerged as key enablers of human-like interactions across diverse sectors. Nevertheless, the balance between linguistic nuance and factual accuracy has proven elusive.
Ahtsham Zafar, Venkatesh Balavadhani Parthasarathy, Chan Le Van, Saad Shahid, Aafaq Iqbal Khan, Arsalan Shahid   +5 more
doaj   +1 more source

Integrating a High-Reliability Multicriteria Trust Evaluation Model with Task Role-Based Access Control for Cloud Services [PDF]

, 2021
Salah T. Alshammari, Aiiad Albeshri, Khalid Alsubhi   +2 more
openalex   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

CRABAC: Combined Role-Attribute Based Access Control Model

, 2023
Abhimanyu Bansal
openalex   +2 more sources