Results 151 to 160 of about 6,987,443 (300)

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Obtaining and Documenting Informed Consent: An Advanced UME Cross-Specialty, Role-Playing Skill Builder. [PDF]

MedEdPORTAL
Tyagi R, Greene EA, Lachman L, Hamaoka DA, Mullenix PS, Mangal J, Swanberg MM, Diana EG, Cozza KL.   +8 more
europepmc   +1 more source

Use of a Role-Playing Activity To Increase Student Understanding of Bacterial Gene Regulation. [PDF]

J Microbiol Biol Educ, 2023
Sampath V.
europepmc   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Contribution of Medical Education through Role Playing in Community Health Promotion: A Review. [PDF]

Iran J Public Health, 2023
Bharti RK.
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Using a virtual reality role-playing game to enhance interaction dynamics and improve social attitudes toward transgender people. [PDF]

Sci Rep
Crone CL, Kallen RW, Richardson MJ.
europepmc   +1 more source

Social skills training with a tabletop role-playing game, before and during the pandemic of 2020: in-person and online group sessions. [PDF]

Front Psychiatry, 2023
Henning G, de Oliveira RR, de Andrade MTP, Gallo RV, Benevides RR, Gomes RAF, Fukue LEK, Lima AV, de Oliveira MBBZN, de Oliveira DAM, Werpp M, Moraes L, Neto FL.   +12 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

The Effectiveness of Peer Education, Mentorship and Role-Playing Approaches in Developing Clinical Skills Among Iranian Nursing Students: A Systematic Review. [PDF]

Health Sci Rep
Ghonchehpour A, Alipoor M, Farmitani Z, Ghorbani F, Nouhi E.   +4 more
europepmc   +1 more source