Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
The Effectiveness of Peer Education, Mentorship and Role-Playing Approaches in Developing Clinical Skills Among Iranian Nursing Students: A Systematic Review. [PDF]
Health Sci RepGhonchehpour A +4 more
europepmc +1 more source
Social skills training with a tabletop role-playing game, before and during the pandemic of 2020: in-person and online group sessions. [PDF]
Front Psychiatry, 2023 Henning G +12 more
europepmc +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Enhancing dental students' motivation and legal knowledge via courtroom role-playing. [PDF]
BMC Med EducHsu WC +4 more
europepmc +1 more source
Sex Differences in Competitiveness in Massively Multiplayer Online Role-Playing Games (MMORPGs). [PDF]
Evol Psychol, 2022 Deaner RO, Dunlap LC, Bleske-Rechek A.
europepmc +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
The efficacy of virtual reality flipped learning with collaborative role-playing in nursing education. [PDF]
BMC NursLi Y, Wu JG, Zhang D, Chen Y.
europepmc +1 more source
Evaluating the Feasibility of a Multiplayer Role-Playing Game as a Behavioral Health Intervention in Adolescent Patients With Chronic Physical or Mental Conditions: Protocol for a Cohort Study. [PDF]
JMIR Res Protoc, 2023 Babichenko D +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source