Results 61 to 70 of about 6,987,443 (300)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

What it Means to Create Player Characters for Tabletop Role-Playing Games: Focusing on Setting a Character's Gender and History

open access: yes, 2022
本論文は, 第1著者が成城大学社会イノベーション研究科に提出した修士論文をもとにしたものである. 内容の一部は, 日本質的心理学会でも発表された(青山・五十嵐 2021).テーブルトップ・ロールプレイング・ゲーム(TRPG)では, プレイヤーが自由にプレイヤーキャラクターを創作することができる. そのことが, プレイヤーにとってどのような意味があるのかを, インタヴュー調査とフィールド観察という2つの調査から探索的に検討した.
青山, 征彦, 五十嵐, 梨々花
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Moving between virtual and real worlds: second language learning through massively multiplayer online role playing games (MMORPGs) [PDF]

open access: yes, 2011
Massively Multiplayer Online Role Playing Games (MMORPGs) bring players together in a large virtual community. This type of online gaming can serve many purposes such as entertainment, social interaction, information exchange and education and is now an ...
Isara Kongmee   +7 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Analisis Penerapan Metode Discussion Dan Role Playing Untuk Meningkatkan Prestasi Belajar Mahasiswa Pada Mata Kuliah Manajemen Kinerja

open access: yesJurnal Ilmiah Manajemen dan Bisnis, 2017
This study aims to analyze the influence of the application of discussion and role playing methods in the performance management class, whether more effective than the lecture method previously used by most students.
Susi Handayani, Hasrudy Tanjung
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

GAME DESIGN AND ROLE-PLAYING GAMES

open access: yes
This chapter explores role-playing games (RPGs) from a design perspective. While there are many approaches to acquiring knowledge about RPGs, designers of RPGs often consider the structural elements of a game-its rules and the entities on which the rules
Björk, Staffan,, Zagal, José P.
core   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Transformative Role-playing Game Design [Elektronisk resurs]

open access: yes
This textbook describes theory and practice in analog role-playing game (RPG) design that encourage specific transformative impacts in participants, including tabletop, live action role-playing (larp), and Nordic and American freeform.
Brind, Simon   +2 more
core   +1 more source

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