Results 121 to 130 of about 9,858,034 (315)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

From role-playing to role-taking: Interpreter role(s) in healthcare

, 2013
Natacha Sarah Alexandra Niemants
openalex   +2 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

The role of oxidant stress and gender in the erythrocyte arginine metabolism and ammonia management in patients with type 2 diabetes

, 2019
Martha Lucinda Contreras-Zentella, Lourdes Sánchez-Sevilla, Juan Antonio Suárez‐Cuenca, Marisela Olguín-Martínez, Martha G. Alatriste‐Contreras, Norberto García-García, Lorena Orozco, Rolando Hernández‐Muñoz   +7 more
openalex   +2 more sources

The role of breakup and coalescence in fine-scale bubble-induced turbulence. I. Dynamics [PDF]

, 2022
I. Paul, Bruño Fraga, Michael Dodd, Chris C. K. Lai   +3 more
openalex   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

The Impact of Information and Communication Technology (ICT) on the Environmental Quality in Iran [PDF]

Pizhūhishnāmah-i Iqtiṣād-i Inirzhī-i Īrān, 2012
fyroze Fallahi, Sakineh Sojudi, Seyab Mamipours   +2 more
doaj  

Uncovering a Novel Role of ROR1 in the Epigenetic Regulation of Tumor Suppressor Gene CREB3L1 in Triple-Negative Breast Cancer Cells [PDF]

Victoria L. Reed, Eric Lalu, Leena Yoon, Norman Fultang, Bela Peethambaran   +4 more
openalex   +1 more source

Role of the DDX11 DNA Helicase in Warsaw Breakage Syndrome Etiology [PDF]

, 2021
Diana Santos, Mohammad Mahtab, Ana Boavida, Francesca M. Pisani   +3 more
openalex   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source