Results 161 to 170 of about 849,980 (294)

Spatially Resolved Multiomics Reveals Metabolic Remodeling and Autophagy Activation in Adamantinomatous Craniopharyngiomas

Advanced Science, EarlyView.
Multiomics integration analysis reveals the “cystic fluid–tumor cell” metabolic coupling that mediates active choline/ethanolamine uptake of tumor cells from cystic fluid and PC/PE synthesis pathways reprogramming that mediating autophagy pathway activation within ACP. ABSTRACT Adamantinomatous craniopharyngioma (ACP), a benign yet highly recurrent and
Dongting Chen, Yahui Gao, Yulin Wang, Ting Lei, Zheng Qu, Yuhan An, Jiaxu Fu, Xin Li, Fangjun Liu, Yan Li   +9 more
wiley   +1 more source

Navigating workplace uncertainty: a path analysis of perceived overqualification, covert narcissism, workplace alienation, and role ambiguity among nurses. [PDF]

BMC Nurs
Mohamed HS, Elbakry MAAE, Othman AA, Atta MHR, Barakat AM, Hamed AEM.   +5 more
europepmc   +1 more source

Compartmentalized Homeostasis Drives High Bamboo Forest Productivity under Nutrient Imbalance

Advanced Science, EarlyView.
This study reveals how Moso bamboo achieves high productivity despite nutrient‐poor soils. It employs a unique strategy, maintaining strict nutrient balance in its leaves while using woody tissues as flexible storage reservoirs. This compartmentalized mechanism buffers the plant from soil phosphorus limitation and microbial competition, resolving the ...
Zhikang Wang, Quan Li, Man Shi, Marcio F.A. Leite, Xinli Chen, Eiko E. Kuramae, Viviane Cordovez, Tingting Cao, Chenglei Zhu, Libin Zhou, Wenjuan Yu, Zhiyao Tang, Changhui Peng, Xinzhang Song   +13 more
wiley   +1 more source

The Mediating Effects of COVID-19 Infection Control Fatigue on Quiet Quitting: Focusing on Organisational Justice, Role Ambiguity and Job Satisfaction. [PDF]

J Adv Nurs
Kang J, Jeong W, Kim S.
europepmc   +1 more source

Nanoparticle Immunoadjuvant Complexes Augment Germinal Center Responses to Vaccination

Advanced Science, EarlyView.
Scaffolding IL‐21 on the surface of a self‐assembling nanoparticle immunogen drives improved germinal center and humoral immune responses. These nanoparticle immunoadjuvant complexes (NICs) functionally modulate the germinal center driving improved somatic hypermutation and antibody maturation, suggesting this platform has potential utility as a ...
Nicholas J. Tursi, Colby J. Agostino, Jinwei Huang, Toshitha Kannan, Niklas Laenger, Jennifer Londregan, Katlyn Lederer, Michaela Helble, Nicole Bedanova, Cory Livingston, Ebony N. Gary, Madison McCanna, Marta Tarquis Medina, Rumi Habib, Ignacio Rodriguez Relaño, Ivan Maillard, Ami Patel, David Allman, Andrew Kossenkov, Amelia Escolano, Daniel W. Kulp, David. B. Weiner   +21 more
wiley   +1 more source

A Modular DNAzyme for Precise Visualization and Intervention of Alternative Splicing Isoforms in Live Cells

Advanced Science, EarlyView.
A Stringent dUPlex‐activated Error Robust (SUPER) DNAzyme system enables real‐time imaging of alternative mRNA splicing (e.g., Bcl‐xL/Bcl‐xS) in living cells via target‐triggered split‐DNAzyme reassembly and dual‐color fluorescence. It also achieves mRNA‐selective knockdown through DNAzyme‐based gene regulation, serving as a versatile tool for splicing
Mengru Lin, Jiale Sun, Yuqing Mao, Yuhao Tang, Fuan Wang, Zhihong Liu, Jing Wang   +6 more
wiley   +1 more source

The cost of protecting resources: a cross-sectional study on the interaction between LMX and role ambiguity on work addiction and burnout among Canadian first-level healthcare managers. [PDF]

Front Psychol
Maisonneuve F, Groulx P, Galy A, Chênevert D, Cossette M.   +4 more
europepmc   +1 more source

Time‐Efficient and Informatic‐Skill‐Light Gap‐Filling for Telomere‐to‐Telomere Genome Assembly

Advanced Science, EarlyView.
The paper introduces a novel auxiliary software toolbox GapSuite, consisting of two tools Gap‐Aid and Gap‐Graph, which guides users to fill gaps in chromosome‐level genome assembly using sequence‐extension‐based and assembly‐graph‐based strategies. The two tools enable users with limited informatics expertise to efficiently complete gap‐filling on ...
Dong Xu, Xianjia Zhao, Lianguang Shang, Shaolong Tian, Yanchun Li, Huaming Wen, Qiang Xu, Dongxi Li, Weihua Pan   +8 more
wiley   +1 more source

Roles and Role Ambiguity in Patient- and Caregiver-Performed Outpatient Parenteral Antimicrobial Therapy. [PDF]

Jt Comm J Qual Patient Saf, 2019
Keller SC, Cosgrove SE, Arbaje AI, Chang RH, Krosche A, Williams D, Gurses AP.   +6 more
europepmc   +1 more source

Biomechanics‐Driven 3D Architecture Inference from Histology Using CellSqueeze3D

Advanced Science, EarlyView.
CellSqueeze3D reconstructs 3D cellular architecture from standard 2D histology images using biomechanical constraints and optimization. Validated on clinical datasets, it enables accurate tissue phenotyping, predicts gene mutations, and reveals significant correlations between nuclear‐cytoplasmic ratio entropy and tumor progression.
Yan Kong, Hui Lu
wiley   +1 more source