Results 101 to 110 of about 2,156,002 (255)

The Effects of Video Games on Human Intelligence [PDF]

open access: yes, 2018
With the help of rapidly growing electronics industry offering more affordable electronic gaming devices, an increasing number of people have stepped into the realm of video games and as a result, playing video games has become part of life for many to ...
Hu, Wenxiang, Yuan, Lifeng
core   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Understanding Computer Role-Playing Games: A Genre Analysis Based on Gameplay Features in Combat Systems [PDF]

open access: yes, 2013
A game genre as diverse as that of computer role-playing games is difficult to overview. This poses challenges or both developers and researchers to position their work clearly within the genre.
Björk, Staffan   +1 more
core   +3 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

THE EFFECT OF ROLE PLAYING METHOD TOWARD THE ABILITY OF FICTION READING COMPREHENSION OF HEARING IMPAIRMENT STUDENT

open access: yesJurnal Penelitian dan Pengembangan Pendidikan Luar Biasa, 2016
This research was carried out with the aim at describing: (1) the ability of fiction reading comprehension of student with hearing impairment of grade VIII at SMPLBN Malang before and after being applied role playing method, (2) the effect of role ...
Lestari Wahyuningtyas   +1 more
doaj   +2 more sources

Game-Based Teaching Methodology and Empathy in Ethics Education

open access: yes, 2018
This article describes the experience of a group of educators participating in a graduate course in ethics. Playing role playing games and the work accompanying that play were the predominate methodology employed in the course.
Bryant, Danielle   +5 more
core  

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

The world as quantized minimal surfaces

open access: yes, 2012
It is pointed out that the equations $\sum_{i=1}^d [X_i,[X_i,X_j]]=0$ (and its super-symmetrizations, playing a central role in M-theory matrix models) describe noncommutative minimal surfaces -- and can be solved as ...
Arnlind, Joakim, Hoppe, Jens
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

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