Results 111 to 120 of about 2,156,002 (255)
Developing and playing a Role-Playing Game in the Kat River Valley: KatAware. Reflexions on the process : WRC Project n° K5/1496 [PDF]
, 2007 Within the Water Research Commission (WRC) project: "A stakeholder driven process to develop a catchment management plan for the Kat River Valley", the Companion Modeling (ComMod) approach (Barreteau et al, 2003) was adopted to help the local Water Users
Farolfi, Stefano
core
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
RPGs to enhance the second language acquisition of both Mandarin and English [PDF]
, 2019 Research Question: “To what degree can it be evidenced that interactive role playing games enhance the mutual second language acquisition of both Mandarin and English?”♦ Small scale side project to ascertain avatar interaction preferences based on ...
Dempster, Euan W., Harbord, Charly
core
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
The Profession of Law: Columbia Law School’s Use of Experiential Learning Techniques to Teach Professional Responsibility [PDF]
, 1995 Columbia Law School\u27s ethics course, The Profession of Law, is an interactive, experiential exploration of legal ethics. The course puts students in a role and asks them to deal, with issues that most of them are likely to encounter, and then the ...
Liebman, Carol Bensinger
core +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
On some systems controlled by the structure of their memory
, 2010 We consider an optimal control problem governed by an ODE with memory playing the role of a control. We show the existence of an optimal solution and derive some necessary optimality conditions.
Buttazzo, Giuseppe, Tahraoui, Rabah
core
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Pengaruh Model Role Playing Terhadap Kemampuan Berbalas Pantun Siswa Kelas X SMA Parulian 2 Medan Tahun Pembelajaran 2013/2014 [PDF]
, 2014 Penelitian ini bertujuan untuk mengetahui pengaruh model pembelajaran role playing terhadap kemampuan siswa berbalas pantun siswa kelas X SMA Parulian 2 Medan tahun pembelajaran 2013/2014. Populasi penelitian ini adalah seluruh siswa kelas X SMA Parulian
silalahi, N. (Nurtani)
core
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source