Results 121 to 130 of about 6,570,416 (336)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Theory Exploration: a role for Model Theory?

open access: yesEPiC Series in Computing, 2018
There is an empirical claim that, when exploring amathematical theory, after a succession of key results have beenobtained, a point of equilibrium is reached where any query ofinterest can be resolved by routine reasoning from the resultsalready established. Here is suggested some ways of thinking aboutthe situation, in general.
openaire   +2 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

The case of the missing ‘If’: Accessibility relations in Stalnaker’s theory of conditionals [PDF]

open access: yes
A part of Stalnaker (1968)’s influential theory of conditionals has been neglected, namely the role for an accessibility relation between worlds. I argue that the accessibility relation does not play the role intended for it in the theory as stated, and ...
Mandelkern, Matthew
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Social Factors Forming Differences in the Discourse on the Quality of School Education

open access: yesВопросы образования
The quality of school education is not only a normative, but also a social concept that is a part of the actual communicative field for almost all social groups.
Natalia A. Senina   +2 more
doaj   +1 more source

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