Results 51 to 60 of about 958,096 (256)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

اتجاهات خطـــاب الصحف الإلكترونية العربية والدولية نحو الجهود المصرية الدبلوماسية تجاه الحرب الإسرائيلية علي غزة دراسة تحليلية مقارنة في إطار نظرية الدور وتحليل السياسة الخارجية [PDF]

المجلة المصرية لبحوث الإعلام
استهدفت الدراسة رصد وتحليل وتفسير اتجاهات المعالجة الصحفية التي تقدمها الصحف العربية والدولية حول الجهود المصرية الدبلوماسية تجاه حرب غزة، ، كذلك التعرف علي القوى الفاعلة وأنواع الاطر الخبرية ومسارات البرهنة التي استخدمتها واتجاهها والأطر المرجعية التي ...
مهيرة عماد فتحي محمد السباعي
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

The professional self-awareness of urban planners in the field of role-playing (Case study: The planning environment of Tehran metropolitan) [PDF]

برنامه‌ریزی توسعه شهری و منطقه‌ای
The aim of this paper is to understande the professional role of urban planners in confronting the complexities and conflicts within the process and environment of metropolitan planning in Tehran.
Pouya Joudi Gollar, Kasra Ashouri
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Security provider meets security seekers: Explaining the support for China’s Global Security Initiative through role alignment

European Journal of International Security
China’s Global Security Initiative (GSI), launched in 2022, has rapidly turned into a flagship programme through which Beijing seeks to present itself as an international security actor and foster strategic alignment both within and beyond its immediate ...
Sebastian Biba, Julia Gurol
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Norm proponents as drivers of deinstitutionalisation: the case of Germany’s arms export to Israel

Frontiers in Political Science
International norms are typically assumed to erode through the actions of their opponents, that is, states that reject or openly undermine established regulatory frameworks.
Nadine Ansorg
doaj   +1 more source