Results 61 to 70 of about 915,030 (255)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

The European Union’s role in a changing International Order: The Global Gateway Initiative [PDF]

open access: yesPopulação e Sociedade
The power structures and norms of the Liberal International Order (LIO) are changing due to the rise of powers with reformist and revisionist agendas.
Flávio Bastos da Silva
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

open access: yesFEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa   +3 more
wiley   +1 more source

Foreign Policy Analysis

open access: yesCzech Journal of International Relations, 2019
Role theory, which is based on the symbolic interactionism of George H. Mead, is increasingly used in foreign policy analysis. The goal of this paper is twofold.
Vít Beneš
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

Lider-Üye Etkileşimine Çok Boyutlu Yaklaşım: Liden ve Maslyn’in Dört Boyutlu Lider-Üye Etkileşim Ölçeğinin Psikometrik Özelliklerine Yönelik Görgül Bir Araştırma

open access: yesAkademik İncelemeler Dergisi, 2014
Lider-üye etkileşim teorisi ile ilgili erken dönem çalışmalarının çoğunda lider ile üyeler arasındaki ilişkiler tek boyutlu bir yaklaşımla ele alınmıştır.
Esin Cevrioğlu   +2 more
doaj  

Refining the Definition of Student Peer Feedback: The Role of Roles

open access: yesHermes
Refining the definition of student peer feedback in text production pedagogy and extending the definition to include the concept of peer-feedback roles, this article roots in higher education and explores definitions of peer feedback based on multiple ...
Carmen Heine, Anja Vesterager
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

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