A multifaceted examination of the action of PDE4 inhibitor rolipram on MMP2/9 reveals therapeutic implications. [PDF]
Sci RepA PDE4 (phosphodiesterase 4) inhibitor, Rolipram, was previously found to down-regulate (in a manner dependent on cAMP (cyclic adenosine monophosphate)-PKA (protein kinase A)) MMP2 (matrix metalloproteinase 2) and MMP9 protein expression levels ...
Bagchi A, Roy A, Halder A, Biswas A.
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The Antidepressant and Antiinflammatory Effects of Rolipram in the Central Nervous System [PDF]
CNS Neuroscience & Therapeutics, 2001 ABSTRACTRolipram is a selective inhibitor of phosphodiesterases (PDE) IV, especially of the subtype PDE IVB. These phosphodiesterases are responsible for hydrolysis of the cyclic nucleotides cAMP and cGMP, particularly in nerve and immune cells. Consequences of rolipram‐induced elevation of intracellular cAMP are increased synthesis and release of ...
Bengt Winblad, Jie Zhu
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Rolipram, a Selective Phosphodiesterase 4 Inhibitor, Ameliorates Mechanical Hyperalgesia in a Rat Model of Chemotherapy-Induced Neuropathic Pain through Inhibition of Inflammatory Cytokines in the Dorsal Root Ganglion [PDF]
Frontiers in Pharmacology, 2017 Chemotherapy-induced neuropathic pain is a significant side effect of chemotherapeutic agents and is the most common reason for stopping chemotherapy. The aim of the present study was to find the major site and mechanisms of action by which rolipram, a ...
Hee Kee Kim, Salahadin Abdi
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Drug Target Insights, 2014 The role of phosphodiesterase (PDE) inhibitors in central nervous system has been investigated and shown to stimulate neuronal functions and increase neurogenesis in Alzheimer patients.
Oguz Mutlu, Pelin Tanyer
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The protective effect of the PDE-4 inhibitor rolipram on intracerebral haemorrhage is associated with the cAMP/AMPK/SIRT1 pathway [PDF]
Scientific Reports, 2021 Rolipram specifically inhibits phosphodiesterase (PDE) 4, thereby preventing inactivation of the intracellular second messenger cyclic adenosine monophosphate (cAMP).
Xiao-Liu Dong +3 more
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Enantiodivergent Synthesis of (R)- and (S)-Rolipram [PDF]
Molecules, 1998 Both enantiomers of rolipram (1) have been prepared in large quantity from a common intermediate rac-3-(3’-cyclopentyloxy-4’-methoxy)phenyl-4-nitro butyric acid (6), which was resolved by way of the two readily separable diastereoisomeric ...
Esteban Pombo-Villar +7 more
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Effect of Rolipram on in vitro maturation, gene expression and embryonic development in bovines [PDF]
Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2019 The aim of this work was to evaluate the effect of the Rolipram during the maturation of bovine oocytes and gene expression of embryos produced in vitro. Bovine ovaries were collected in slaughterhouse.
B.B. Santana +7 more
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Rolipram, a PDE4 Inhibitor, Enhances the Inotropic Effect of Rat Heart by Activating SERCA2a
Frontiers in Pharmacology, 2019 This study was designed to investigate the hemodynamic effect of rolipram, a phosphodiesterase type 4 (PDE4) inhibitor, in normal rat hearts both in vivo and in vitro and its underlying mechanism.
Ming Xie, Yuwei Wang, Mohamed Boutjdir
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Cyclic AMP signaling promotes regeneration of cochlear synapses after excitotoxic or noise trauma. [PDF]
Front Cell NeurosciIntroductionCochlear afferent synapses connecting inner hair cells to spiral ganglion neurons are susceptible to excitotoxic trauma on exposure to loud sound, resulting in a noise-induced cochlear synaptopathy (NICS).
Hemachandran S, Hu N, Kane CJ, Green SH.
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Rolipram Improves Outcome in a Rat Model of Infant Sepsis-Induced Cardiorenal Syndrome
Frontiers in Pharmacology, 2017 While the mortality rate associated with sepsis in children has fallen over the years, it still remains unacceptably high. The development of both acute cardiac dysfunction and acute kidney injury during severe sepsis is categorized as type 5 cardiorenal
Sharda P Singh, Shengyu Mu
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