Results 91 to 100 of about 11,777 (278)

Targeting Remyelination in Spinal Cord Injury: Insights and Emerging Therapeutic Strategies

CNS Neuroscience &Therapeutics, Volume 30, Issue 12, Page 1-15, December 2024.
Exploring the potential targeted therapy of remyelination after spinal cord injury: The review demonstrates the possibility of stimulating oligodendrocyte precursor cell proliferation, differentiation, and myelin sheath formation in both in vitro and in vivo SCI models through molecular pathway modulation and pharmacological agents.
Abdullah Al Mamun, Zhou Quan, Peiwu Geng, Shuanghu Wang, Chuxiao Shao, Jian Xiao   +5 more
wiley   +1 more source

Pharmacological analysis of the feeding response of codling moth (Cydia pomonella; Lepidoptera: Tortricidae) neonates to bitter compounds

European Journal of Entomology, 2017
Feeding in codling moth neonate caterpillars was inhibited by 0.67 mM and 2.24 mM concentrations of denatonium benzoate. This inhibitory effect was abolished by phospholipase C inhibitor, U-73122 and the phosphodiesterase inhibitor, Rolipram. Quinine and
Maciej A. PSZCZOLKOWSKI
doaj   +1 more source

The human area postrema and other nuclei related to the emetic reflex express cAMP phosphodiesterases 4B and 4D [PDF]

, 2017
Phosphodiesterase 4 (PDE4) inhibitors, i.e. rolipram, are being extensively investigated as therapeutic agents in several diseases. Emesis is one of the most common side effects of PDE4 inhibitors.
Beleta, J., Caro, R. de, Gavaldà, A., Macchi, V., Mengod Los Arcos, Guadalupe, Mori, F., Palacios, José M., Porzionato, A., Pérez-Torres, Silvia   +8 more
core   +1 more source

The Role of Water Networks in Phosphodiesterase Inhibitor Dissociation and Kinetic Selectivity

ChemMedChem, Volume 19, Issue 22, November 18, 2024.
Phosphodiesterase (PDE) inhibitor selectivity and binding kinetics can be rationalized with the help of biophysical and computational methods. Water molecules have been found to influence the stability of a key hydrogen bond affecting the kinetic selectivity of inhibitors.
Antoni R. Blaazer, Abhimanyu K. Singh, Lorena Zara, Pierre Boronat, Lady J. Bautista, Steve Irving, Maciej Majewski, Xavier Barril, Maikel Wijtmans, U. Helena Danielson, Geert Jan Sterk, Rob Leurs, Jacqueline E. van Muijlwijk‐Koezen, David G. Brown, Iwan J. P. de Esch   +14 more
wiley   +1 more source

Efecto del inhibidor de fosfodiesterasa tipo 4 -rolipram, sobre la maduración in vitro de oocitos bovinos Efeito do inibidor de fosfodiesterasa tipo 4 -rolipram, sobre a maturação in vitro de oocitos bovinos Effect of phosphodiesterase type 4-inhibitor rolipram on in vitro maturatrion of bovine oocytes

Revista Colombiana de Ciencias Pecuarias, 2008
Durante el proceso de maduración in vitro de oocitos, las gonadotropinas FSH y LH inducen la producción de AMPc. El AMPc tiene efecto dual, donde los altos niveles de AMPc intraoocitario mantienen su bloqueo meiótico, mientras que en las células de la ...
Yuddy S López, Ana M Mejía, Elder E Escobar, Bernardo Agudelo Jaramillo, Neil A Vásquez Araque, Hernán Echavarría   +5 more
doaj  

Multidrug resistance protein 4/ ATP binding cassette transporter 4: a new potential therapeutic target for acute myeloid leukemia [PDF]

, 2014
Less than a third of adults patients with acute myeloid leukemia (AML) are cured by current treatments, emphasizing the need for new approaches to therapy.
Beyrath, Julien, Bruzzone, Ariana, Cany, Jeannette, Copsel, Sabrina Natalia, Davio, Carlos Alberto, May, Maria, Russel, Frans G. M., Shayo, Carina Claudia, Wargon, Victoria   +8 more
core   +2 more sources

Innovative pathological network‐based multitarget approaches for Alzheimer's disease treatment

Medicinal Research Reviews, Volume 44, Issue 6, Page 2367-2419, November 2024.
Abstract Alzheimer's disease (AD) is the most prevalent neurodegenerative disease and is a major health threat globally. Its prevalence is forecasted to exponentially increase during the next 30 years due to the global aging population. Currently, approved drugs are merely symptomatic, being ineffective in delaying or blocking the relentless disease ...
Paloma Mayo, Jorge Pascual, Enrique Crisman, Cristina Domínguez, Manuela G. López, Rafael León   +5 more
wiley   +1 more source

Potent PDE4 inhibitor activates AMPK and Sirt1 to induce mitochondrial biogenesis.

PLoS ONE, 2021
AMP-activated protein kinase (AMPK) is an evolutionarily conserved energy sensor. Activation of AMPK leads to a number of metabolic benefits, including improved mitochondrial function in skeletal muscle and lowering of serum glucose levels in type-2 ...
Sung-Jun Park, Faiyaz Ahmad, Robert J Bahde, Andrew Philp, Jeonghan Kim, Tianjiao Huang, Myung K Kim, William C Trenkle, Jay H Chung   +8 more
doaj   +1 more source

Rolipram und tageszeitliche Rhythmen an Ratten

, 2013
Die pharmakologische Wirkung von Rolipram, einem Phosphodiesterase 4 Hemmer, wird an männlichen WISTAR-Ratten mit einer Dosis von 2,5 mg/kg Körpergewicht untersucht. Der Versuchsablauf ist gekennzeichnet durch eine über insgesamt 24 Stunden in jeweils zweistündigem Abstand durchgeführte jeweils sechzigminütige Verhaltensbeobachtung, die unter einem 12 ...
openaire   +1 more source

Activation of the hypoxia response in the aging cerebrovasculature protects males against cognitive impairment

Aging Cell, Volume 23, Issue 10, October 2024.
Cerebrovasculature aging leads to blood–brain barrier damage, contributing to the onset of Alzheimer's disease (AD). The male brain produces significant levels of hypoxia‐inducible factors that stimulate angiogenesis and safeguard brain tissue. Increased antigen presentation and decreased angiogenesis capacity during the cerebrovasculature aging in ...
Peihu Li, Xiaoman Bi, Dahua Xu, Yuan Meng, Yucheng Xia, Jiale Cai, Yutong Shen, Jiaqi Wang, Jiazhu Chen, Lamei Yin, Bo Wang, Deng Wu, Kongning Li   +12 more
wiley   +1 more source