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Modulation of oxazolone-induced hypersensitivity in mice by selective PDE inhibitors

Mediators of Inflammation, 1995
The effects of PDE inhibitors on oxazolone-induced contact hypersensitivity (CS) were studied in mice. Rolipram, Ro 20-1724 and theophylline dose dependently inhibited CS but none caused >53% inhibition. ED30 values at 24 h before challenge for rolipram,
I. Moodley, Y. Sotsios, B. Bertin
doaj +1 more source

Phosphodiesterase 4B is essential for lipopolysaccharide-induced CC chemokine ligand 3 production in mouse macrophages

Journal of Medical Sciences, 2015
Background: Phosphodiesterase 4 (PDE4) inhibitors negatively modulate many inflammatory responses, and some of these pharmacological effects are mediated by inhibition of PDE4B in inflammatory cells.
Ciou-Rong Lai +8 more
doaj +1 more source

Three-Dimensional Structures of PDE4D in Complex with Roliprams and Implication on Inhibitor Selectivity [PDF]

, 2003
Qing Huai +5 more
openalex +1 more source

Crystal Structure of 5-t-Butoxycarbonyl-l-benzoyl-2-pyrrolidinone, an Intermediate in the Synthesis of (-)-Rolipram [PDF]

, 2002
Adrián Covarrubias‐Zúñiga +2 more
openalex +1 more source

Inhibition of PDE‐4 isoenzyme attenuates frequency and overall contractility of agonist‐evoked ureteral phasic contractions

Pharmacology Research & Perspectives
The aim of this study was to investigate the functional role of phosphodiesterase enzymes (PDE) in the isolated porcine ureter. Distal ureteral strips were mounted in organ baths and pre‐contracted with 5‐HT (100 μM).
Iris Lim +4 more
doaj +1 more source

Administration of the phosphodiesterase type 4 inhibitor rolipram into the amygdala at a specific time interval after learning increases recognition memory persistence [PDF]